A cryogenic storage system includes a transfer module configured to service one or more cryogenic storage freezers. The transfer module includes a working chamber that maintains a cryogenic environment for the transfer of sample tubes between different sample boxes. One or more freezer ports enable the transfer module to receive a sample box extracted from a respective freezer. An input/output (I/O) port enables external access to samples. A box transport robot operates to transport sample boxes between the freezer ports, the working chamber, and the I/O port. A picker robot operates to transfer sample tubes between sample boxes within the working chamber.

A closure is configured for use with a portable cryogenic container or dewar, such as a dry vapor shipper (DVS). The closure has advanced insulating properties which enhances cryogen residence time and also minimizes negative effects on residence time when the dewar is placed on its side, such as during shipping. The closure includes a gas vent in the form of a fluid passage which is particularly sized to minimize thermal leakage and located away from the closure-to-neck interface. Embedded electronics can detect, record, and/or communicate information pertinent to a condition of the storage container in which the closure is installed.

The invention relates to a machine for labeling blank-labeled cryogenically-frozen vials or ampoules, which contain heat-labile biological materials, and to which a laser-light sensitive material had been applied prior to freezing. Accordingly, the machine has been designed to maintain the integrity of the biological materials throughout all phases of the labeling process. The machine generally comprises a master control system; a programmable user interface; a frame; cryogenic freezer assemblies, for keeping the vials at the required low temperatures; an infeed assembly, configured to receive and position blank-labeled cryogenic vials; a cryostatic labeling/quality control tunnel, wherein the vials are maintained at the required temperature, labeled by laser ablation, and checked for quality; and, an outfeed assembly. The machine further comprises a means for transporting the vials from the infeed assembly to the tunnel, and from the tunnel to the outfeed assembly. Vials labeled according to the instant disclosure are ultimately manually or automatically loaded into cryogenic shipping containers.

A high pressure cryogenic process for cooling a biological material, comprising the solidification of the biological material by a cryogenic fluid, wherein the solidification of the biological material is carried out at a cryogenic temperature at a pressure of at least 10 bar and the cryogenic fluid is present in an amount greater than 200 kg/m3.

An installation for handling and storing biological samples at very low temperatures includes a cartesian robot and an articulated-arm robot having at least five degrees of freedom. A biobank which uses, working jointly, a five-axis or six-axis or seven-axis robot supported by a cartesian robot which moves the five-axis or six-axis robot translationally along at least one row of storage containers, advantageously cryogenic containers each incorporating storage columns or racks with a honeycomb structure, of which the cells are able to house individual sample containers.

A biological specimen of a subject is handled and tracked for a procedure involving that specimen. Prior to initiation of the procedure, a first procedure data structure (PDS) is generated. The first PDS binds an identifier corresponding to the subject with an indicator of a procedure to be performed on the specimen and identifiers of a specimen container and a specimen holder that physically contacts the biological specimen, as well as a scheduled time for the procedure. A schedule of a plurality of PDSs including the first PDS, is displayed on a display device of a graphical user interface. Following initiation of the procedure, the first PDS is updated based on user input, and after the procedure, at least a portion of the first PDS, as updated, is stored in a database in conjunction with other PDSs respectively associated with other completed procedures.

A system is provided for transporting, handling and monitoring samples in a temperature-controlled storage environment. The system includes a handheld carrier configured to transfer samples to and from a temperature-controlled storage station and a temperature-controlled container for receiving and housing one or more carriers. The carrier includes an integrated sample identification and temperature sensing capability configured to monitor a thermal history of one or more samples during transport, handling and storage including as the samples are conveyed between the temperature-controlled storage environment and the temperature-controlled container. That is, the carrier is adapted to be held in the hand during use. A carrier for conveying and monitoring samples during transport, handling and storage is also provided.

A stem cell manufacturing system for manufacturing stem cells from somatic cells includes: one or more closed production device(s) configured to produce stem cells from somatic cells; one or more drive device(s) configured to be connected with the production device(s) and drive the production device(s) in such a manner as to maintain the production device(s) in an environment suitable for producing stem cells; one or more cryopreservation device(s) configured to cryopreserve the produced stem cells; a first memory device configured to store whether or not somatic cells have been introduced to the production device(s), as a first state; a second memory device configured to store whether or not the production device(s) is/are connected with the drive device(s), as a second state; and a third memory device configured to store whether or not the produced stem cells can be placed in the cryopreservation device(s), as a third state.

A storage tank for cryogenic liquid having an outer tank constructed of a rigid material and an inner tank contained within and spaced inwardly from the outer tank. A first fill line for cryogenic liquid has a first end open exteriorly of the outer tank and a second end open inside the inner tank. The first fill line is fluidly sealed to both the inner tank and the outer tank and the first fill line has a first predetermined flow rate at a set filling pressure. A valve is associated with the first fill line to selectively open and close the first fill line. A second fill line for cryogenic liquid has a first end open exteriorly of the outer tank and a second end open inside of the inner tank. The second fill line has a second predetermined flow rate at the predetermined filling pressure. Furthermore, the first and second lines are sized so that the first flow rate is several times the second flow rate.

A low temperature storage system includes a cabinet housing and a drawer that is slidable in and out of the cabinet housing. The drawer includes an interior wall and an exterior wall defining an insular space therebetween and a support grid disposed within an interior region defined by the interior wall of the drawer. The support grid defines multiple receptacles arranged in a matrix configuration and respectively sized to receive a storage carrier. The drawer further includes first markings and second markings printed on the drawer in a manner such that any one of the first markings and any one of the second markings together correspond to one of the multiple receptacles arranged in the matrix configuration.