Described here in a composition for use in a device for generating an inhalable medium, the composition comprising (i) 0-50% by weight of air-cured and/or fire-cured tobacco (ii) 40-80% by weight of flue-cured and/or sun-cured tobacco that has not been subjected to any further treatment which affects the flavor properties of tobacco, and (iii) 0-40% by weight of flue-cured and/or sun-cured tobacco that has been further treated to enhance the flavor properties of tobacco.

Compositions configured for oral use, the compositions including at least one active ingredient selected from caffeine, taurine, GABA, theanine, tryptophan, vitamin B6, vitamin B12, vitamin C, lemon balm extract, ginseng, citicoline, sunflower lecithin, or combinations thereof, are provided. The compositions include one or more fillers, including a sugar alcohol, and optionally, a lipid or binder. The compositions may be in chewable, tablet, or meltable forms.