A wide field fundus camera is disclosed to implement multiple illumination beam projectors and to capture multiple retinal images at various viewing angles to facilitate wide field retinal examination. The wide field fundus camera contemplates an ultra-wide field lens that can provide edge to edge imaging of the entire retina at a single alignment. It also contemplates configuration of said multiple illumination beam projectors to provide visualization of retina and Purkinje reflections simultaneously to facilitate determination of proper camera alignment with the eye. It further contemplates control of multiple illumination beam projectors in a programmable manner to capture said multiple retinal images. It further contemplates a real-time algorithm to reduce said reflected and scattered light haze in said retinal images. It further contemplates automated montage of said multiple retinal images into a single wide field FOV retinal montage and automated removal reflected and scattered light haze from said retinal montage.

An ophthalmic imaging device (300) includes a fundus module (210) and a slit lamp 5 module (220) movably coupled to each other. The fundus module (210) includes an illumination module (230) and an imaging module (240). The illumination module (230) is adapted to yield a first partially blocked beam. The imaging module (240) includes a mirror (324) with a hole and an objective lens (326) to produce a reflected first partially blocked beam and a second partially blocked beam, to form a cornea 10 illuminating doughnut (502) and pupil illuminating doughnut (504), respectively, on an anterior region of the eye and form an image of the posterior\\region of the eye on an image plane (346). The slit lamp module (220) is adapted to view and capture the image of anterior and posterior regions of the eye.

[Problem] To allow imaging light to be appropriately received by a second camera in the case where a first imaging mode (color imaging mode) is changed to a second imaging mode (autofluorescence imaging mode). [Solution] In the first imaging mode, using a dichroic mirror 30 allows light LB to be received by both a first camera C1 and a second camera C2. In the second imaging mode, using a transparent glass 31 allows light LB to be received by the second camera C2. With this configuration, both in the first imaging mode and in the second imaging mode, light LB from an ocular fundus is appropriately received by the second camera C2 whereby an appropriate ocular fundus image can be taken.

An imaging device for imaging an eye includes an eyepiece, an illumination system, an imaging system, and a controller. The illumination system includes a light source that emits illumination light along an illumination path through the eyepiece to the eye to produce a retinal diffuse reflection and a corneal specular reflection. The imaging system includes a first camera that captures a retinal image based on the retinal diffuse reflection and a first set of optical elements, a second camera that captures a corneal specular reflection image based on the corneal specular reflection and a second set of optical elements. The first camera captures at least some residual corneal specular reflection in the retinal image. The controller subtracts the residual corneal specular reflection from the retinal image based on the corneal specular reflection image.

An apparatus for imaging an interior of an eye includes a light sensitive sensor, a plurality of light emitters (LEs) capable of outputting light, a plurality of nonvisible light emitters (NV-LEs) capable of outputting nonvisible light, and a controller. The controller is coupled to the plurality of LEs, the plurality of NV-LEs, and the light sensitive sensor, and the controller implements logic that when executed by the controller causes the apparatus to perform operations. The operations include illuminating the eye with the nonvisible light from the plurality of NV-LEs, and determining an amount of reflection of the nonvisible light from the eye for each of the NV-LEs in the plurality of NV-LEs. The operations also include illuminating the eye with selected one or more of the LEs in the plurality of LEs, and capturing, with the light sensitive sensor, a sequence of images of the interior of the eye while the eye is illuminated with the light from the LEs.

A retinal imager for imaging a retina of an eye includes an illumination source operable to generate illumination light and a beam splitter operable to receive the illumination light and direct the illumination light along an optical axis. The retinal imager also includes a field lens disposed along the optical axis and an objective lens disposed along the optical axis and operable to contact a cornea of the eye. An aerial image is formed adjacent to the field lens. The retinal imager further includes an image sensor and one or more lenses disposed along the optical axis between the beam splitter and the image sensor. The one or more lenses are operable to form a sensor image at the image sensor.

A low cost fundus camera uses LED light sources placed adjacent the camera's imaging stop, and thereby eliminates the need for optics for introducing the light source to the camera's optical path. Lens reflex in the pupil relay is avoided by using only reflective optics in the pupil relay. Reflex from the LED is mitigated by actuating each LED separately, one at a time, and capturing a separate image with each actuated LED. Reflex-free regions of each captured image are extracted and combined to create a composite reflex-free image.

Disclosed herein are methods and apparatus for making a determination about an eye in ambient lighting conditions comprising detecting ambient light reflected out of an eye of a subject from a retina of the eye of the subject and making a determination about the eye of the subject based upon the reflected ambient light.

An optical measurement system: passes a probe light beam through a variable focal length lens to the retina of an eye, and returns light from the retina through the variable focal length lens to a wavefront sensor; adjusts the focal length of the variable focal length lens to provide a desired characteristic to at least one of: the probe light beam, and the light returned by the retina to the wavefront sensor; passes a calibration light through the variable focal length lens to the wavefront sensor while the variable focal length lens is at the adjusted focal length to ascertain the adjusted focal length; and makes a wavefront measurement of the eye from the light returned from the retina of the eye through the variable focal length lens to the wavefront sensor, and from the adjusted focal length ascertained from the calibration light received by the wavefront sensor.

A method, a controller, and a non-transitory medium for controlling an optical-image pickup apparatus. Receiving quality data representative of quality of wavefront data. Comparing the quality data to a threshold. Performing normal adaptive optics feedback if the wavefront data is of sufficient quality. Performing an initial adjustment if the wavefront data is not of sufficient quality. The initial adjustment comprising sending control information to modify the optical path in which light is radiated onto a subject. After the initial adjustment, receiving new quality data that is based on new wavefront data after the optical path has been modified. Performing the normal adaptive optics feedback if the quality information indicates that the wavefront data is of sufficient quality. Re-performing the initial adjustment if the new quality information indicates that the wavefront data is not of sufficient quality.