A method of delivering pulsed electric field energy to perform ablation of a tissue includes providing a pulse train to an electrode. The pulse train may include a first set of pulses with a first pulse width to generate first electric field and a second set of pulses with a second pulse width greater than the first pulse width to generate a second electric field. The electrode may be positioned at a same position during generation of the first electric field and the second electric field. The first electric field may be configured to have a higher electroporation effect on the first elongated cells having a first orientation than on second elongated cells having a second orientation. The second electric field may be configured to have a higher electroporation effect on the second cells than on the first cells.

A dynamic balloon angioplasty system for applying a dynamic pressure to fracture hardened materials embedded within an elastic conduit. The system having a pressure source system outputting at least a first predetermined pressure from a pressure source outlet, and an angioplasty unit fluidly coupled to the pressure source outlet receiving at least the first predetermined pressure. The angioplasty unit having an angioplasty inflation device, an angioplasty balloon connector, and an oscillating mechanism selectively actuated to output a plurality of pressure pulses to the angioplasty balloon via a fluid communication path. A control system is configured to determine an optimal hydraulic pressure oscillation frequency and amplitude for a given procedure and output a control signal to the oscillating mechanism, and monitor a pressure signal to detect fracture of the hardened material within the elastic conduit or system failure or leakage.

Systems for treatment of glaucoma comprise an excimer laser, a plurality of fiber probes, and a processor. Each fiber probe is attachable to the excimer laser to treat a subject having glaucoma by delivering shots from the laser. The processor is configured to monitor and limit a variable number of shots delivered by each fiber probe, the number of shots delivered by each fiber probe programmable within a range. Methods of treating glaucoma include programming a fiber probe to deliver a number of shots from an excimer laser. The fiber probe is inserted into an eye of a subject having glaucoma and adjusted to a position transverse to Schlemm's canal in the eye. A plurality of shots is applied from the excimer laser source while the probe is in the transverse position, thereby treating glaucoma by creating a plurality of perforations in Schlemm's canal and/or the trabecular meshwork.

A laser treatment system comprising a plurality of laser devices disposed on a cart, a combiner coupled to the plurality of laser devices, the combiner configured to combine a plurality of laser signals from the plurality of laser devices into a single conducting medium and a treatment head coupled to the conducting medium, the treatment head configured to deliver the plurality of laser signals to a predetermined location.

Systems for treatment of glaucoma comprise an excimer laser, a plurality of fiber probes, and a processor. Each fiber probe is attachable to the excimer laser to treat a subject having glaucoma by delivering shots from the laser. The processor is configured to monitor and limit a variable number of shots delivered by each fiber probe, the number of shots delivered by each fiber probe programmable within a range. Methods of treating glaucoma include programming a fiber probe to deliver a number of shots from an excimer laser. The fiber probe is inserted into an eye of a subject having glaucoma and adjusted to a position transverse to Schlemm's canal in the eye. A plurality of shots is applied from the excimer laser source while the probe is in the transverse position, thereby treating glaucoma by creating a plurality of perforations in Schlemm's canal and/or the trabecular meshwork.

In one embodiment, a medical system includes a catheter configured to be inserted into a body part of a living subject, and including an elongated deflectable element including a distal end, a proximal coupler connected to the distal end, an expandable assembly comprising a plurality of flexible polymer circuit strips, the flexible polymer circuit strips having respective proximal ends connected to, and disposed circumferentially around, the proximal coupler, respective ones of the flexible polymer circuit strips including respective multiple strip electrodes, respective contact arrays disposed at the respective proximal ends, and respective multiple circuit traces electrically connecting the respective multiple strip electrodes with the respective contact arrays, and a plurality of surface mountable electrodes mounted on, and bulging over respective ones of the flexible polymer circuit strips.

A medical apparatus includes a probe, including an insertion tube configured for insertion into a body cavity of a patient and a basket assembly, which has a proximal end that is connected distally to the insertion tube and includes a plurality of resilient spines, which are configured to bow radially outward around a longitudinal axis of the basket assembly and are conjoined at a distal end of the basket assembly. A plurality of electrodes are configured to contact tissue in the body cavity and include radial electrodes disposed on the spines and an axial electrode disposed on the longitudinal axis of the basket assembly. An electrical signal generator is configured to apply to the electrodes, including the axial electrode, pulses having an amplitude sufficient to cause irreversible electroporation (IRE) in the tissue contacted by the electrodes.

A medical probe, including a flexible insertion tube having proximal and distal ends, and a basket assembly at the distal end of the flexible insertion tube. In embodiments of the present invention, the basket assembly includes a plurality of spines and a plurality of electrodes, each of the electrodes having a lumen therethrough fitting a given spine.

A sine wave generator includes a resonator circuit, a control circuit and a pulse generator. The resonator circuit is configured to receive energy pulses and to generate a resonator sinusoidal signal responsively to the energy pulses. The control circuit is configured to estimate a signal measure of the resonator sinusoidal signal, or of a signal derived from the resonator sinusoidal signal. The pulse generator is configured to generate the energy pulses responsive to the signal measure estimated by the control circuit, and to drive the resonator circuit with the energy pulses.

There is provided a hair cutting device for cutting hair on a body of a subject, the hair cutting device comprising a light source for generating light at one or more specific wavelengths corresponding to wavelengths absorbed by one or more chromophores in or on hair; a cutting element that comprises an optical waveguide that is coupled at a first end to the light source to receive light, wherein a portion of a sidewall of the optical waveguide forms a cutting face for contacting hair; a light sensor that is coupled to the optical waveguide away from the first end, wherein the light sensor is for measuring the light level in the optical waveguide and for providing an output signal representing the measured light level; and a control unit that is coupled to the light source, and coupled to the light sensor to receive the output signal, wherein the control unit is configured to determine a measure of the amount of input light transmitted across the optical waveguide from the measured light level and an input light level at the first end of the optical waveguide; and to control the power of the light generated by the light source based on the determined measure.