An ultrasound treatment appliance comprising a surgical handpiece, an ultrasound insert, and an ultrasound generator, the handpiece including a piezoelectric transducer connected to the ultrasound insert and a piezoelectric motor connected to the ultrasound generator. The piezoelectric motor transmits ultrasound waves to the insert, which waves are defined as a function of current and voltage setpoint signals delivered by the ultrasound generator to the piezoelectric motor. The appliance also includes a module for controlling the amplitudes of the setpoint signals and configured to increase or decrease the amplitudes of the current and voltage setpoint signals when the variation in the impedance of the ultrasound signal is greater than a predetermined impedance variation value and when the variation in the frequency of the ultrasound signal is greater than or less than the predetermined frequency variation value.

Some implementations provide a high-powered compact ultrasonic transducer having an integral piezoelectric ceramic force sensing element utilized to enable enhanced tissue selectivity with a piezoelectric based transducer. Some implementations additionally or alternatively relate to methods and apparatus for driving ultrasonic surgical devices, such as methods and apparatus that modulate an amplitude of a drive signal, provided to an ultrasonic surgical device, in accordance with a selected tissue selectivity level. For example, the amplitude of the drive signal for a given tissue selectivity level can be varied with time in accordance with amplitude modification parameters that are particularized to the given tissue selectivity level. Some of those implementations additionally implement a corresponding duty cycle, for the drive signal, that corresponds to the selected tissue selectivity level.

In one embodiment of the present invention, a method of applying ultrasonic energy to a treatment site within a patient's vasculature comprises positioning an ultrasound radiating member at a treatment site within a patient's vasculature. The method further comprises activating the ultrasound radiating member to produce pulses of ultrasonic energy at a cycle period T1 second. The acoustic parameters such as peak power, pulse width, pulse repetition frequency and frequency or any combination of them can be varied non-linearly.

The present disclosure is directed to devices for, and method of, priming the tumor microenvironment with pressure pulses to enhance the efficacy of anticancer therapeutic agents, in a subject in need thereof. Further, increased response of solid tumors locally exposed to stress waves to systemically administered therapeutic agents, is disclosed. The pressure-pulse tumor-priming device comprises: a pulsed laser system (1), a light guide (2) to direct laser pulses to one or more light-to-pressure transducers (3), the one or more light-to-pressure transducers absorbing laser pulses from the pulsed laser system and generating pressure pulses, a tumor-positioning support structure (4) configured to couple one or more light-to-pressure transducers with a solid tumor (5), and a control system (6) to limit the exposure of the solid tumor to the pressure pulses. Anticancer therapeutic agents may be administered before, after or during the priming of solid tumors with pressure pulses.

A surgical instrument system comprising a motor system and a control circuit is disclosed. The motor system comprises a motor and a drive train coupleable to the motor and configured to actuate a firing member through a staple firing stroke. The control circuit is coupled to the motor, wherein, during the staple firing stroke, the control circuit is configured to monitor current draw of the motor and initiate an oscillating impact signal sequence to the motor based on the monitored current draw of the motor. The oscillating impact signal comprises a pulse amplitude selected based on the monitored current draw and a pulse width based on the monitored current draw.

A surgical stapling system includes a motor, a gear reducer assembly, a drive train, and a motor controller. A method of controlling the motor includes applying a first signal to the motor, receiving drive train operational data, comparing the drive train data to baseline data, and applying a signal having a different shape than the first signal to the motor. A method of characterizing the motor includes transmitting a perturbation signal, receiving motor function parameters, determining stapler system characteristics, and adjusting a controller function. A method of controlling a stepper motor includes applying a signal to the stepper motor, receiving stepper motor operational data, comparing the data to baseline data, and adjusting the signal. Another method of controlling the motor includes receiving motor rotational data, receiving gear rotation data, calculating a mechanical transfer function, determining non-idealities of the stapling system, and modifying a control signal based on the non-idealities.

Methods, devices, and systems for controlling a tissue-treatment motion by a surgical instrument are disclosed.

A surgical instrument system comprising a motor system and a control circuit is disclosed. The motor system comprises a motor and a drive train movable by the motor to actuate a firing member through a staple firing stroke. The control circuit is coupled to the motor, wherein, during the staple firing stroke, the control circuit is configured to perform a first sensory action to determine if a speed of the motor can be increased to a first target speed, monitor a result of the first sensory action, adjust a parameter of a subsequent sensory action based on the monitored result of the first sensory action, and perform the subsequent sensory action with the adjusted parameter.

An ultrasonic device may include an electromechanical ultrasonic system defined by a predetermined resonant frequency, the electromechanical ultrasonic system having an ultrasonic transducer coupled to an ultrasonic blade. A method of compensating power delivered to the ultrasonic device may include determining an articulation angle of an articulatable ultrasonic blade coupled to the ultrasonic transducer, adjusting a complex impedance of the ultrasonic transducer to compensate for power lost as a function of the articulation angle, and adjusting, a power applied to the ultrasonic transducer based on the articulation angle. The ultrasonic device may include a generator and a control circuit configured to effect the method.

An ultrasonic device may include an electromechanical ultrasonic system defined by a predetermined resonant frequency, the electromechanical ultrasonic system including an ultrasonic transducer coupled to an ultrasonic blade. A method of controlling energy delivered to the ultrasonic device may include determining an impedance of the ultrasonic transducer during a transection process, analyzing the impedance of the ultrasonic transducer, profiling the ultrasonic blade based on the impedance, and adjusting a power delivered to the transducer during the transection process based on the profile of the blade. The method may further include pulsing, the power delivered to the ultrasonic transducer, determining changes in tissue characteristics of tissue located in an end effector, wherein the changes in tissue characteristics is determined between pulses, and adjusting power delivered to the ultrasonic transducer based on the tissue changes throughout the transection. An ultrasonic instrument may include components configured to effect the method.