A surgical instrument system is disclosed including a surgical instrument, an end effector, and a display. The end effector includes a distal end, a proximal connection portion configured to attach the end effector to the surgical instrument, a first jaw, a second jaw movable relative to the first jaw, and at least one sensor configured to detect an orientation of the second jaw. The second jaw is moveable between an open orientation, a partially-closed orientation, and a closed orientation. The display is configured to incrementally display discrete steps of partial closure of the second jaw.

A system for creating micro-channels through superficial corneal epithelium, the system including: a femtosecond laser having a pulse energy range of 1 to 20 microjoules (μJ) and a capability of generating a laser beam having a wavelength of 700-1100 nanometers (nm) and a repetition rate of 1 kilohertz to 1 megahertz, a laser delivery system comprising a beam expander, a scanning lens having a numerical aperture (NA) of 0.05 to 0.5 and a focusing objective, and control software that controls the delivery system such that the laser beam is scanned in a pattern. The system is used to noninvasively increase corneal epithelial permeability to therapeutic agents through micron-scale channels created through the corneal epithelium by the system or to induce wound healing in a cornea in a subject following creation of micron-scale channels in the cornea.

Systems for treatment of glaucoma comprise an excimer laser, a plurality of fiber probes, and a processor. Each fiber probe is attachable to the excimer laser to treat a subject having glaucoma by delivering shots from the laser. The processor is configured to monitor and limit a variable number of shots delivered by each fiber probe, the number of shots delivered by each fiber probe programmable within a range. Methods of treating glaucoma include programming a fiber probe to deliver a number of shots from an excimer laser. The fiber probe is inserted into an eye of a subject having glaucoma and adjusted to a position transverse to Schlemm's canal in the eye. A plurality of shots is applied from the excimer laser source while the probe is in the transverse position, thereby treating glaucoma by creating a plurality of perforations in Schlemm's canal and/or the trabecular meshwork.

Systems and methods for detecting and disrupting obstructions (such as clot material) within a blood vessel are disclosed herein. In some examples, the present technology comprises a system for detecting and disrupting a clot in a cerebral blood vessel of a patient, where the system comprises a treatment environment, a detection system, and an energy delivery device. The detection system may be configured to determine the presence of a blood clot within a cerebral blood vessel of a patient. In some embodiments, the detection system is configured to obtain data characterizing a position of the clot within the treatment environment. The energy delivery device can be configured to receive the data characterizing the position of the clot and, based on the data, deliver energy to the clot, thereby disrupting the clot and restoring blood flow in the affected blood vessel.

An ultrasonic surgical instrument and method of sealing tissue includes interrogating the tissue with an electrical signal and adjusting an electrical parameter of at least one of the ultrasonic energy or the RF energy in response to the tissue feedback to inhibit transecting the tissue. The ultrasonic surgical instrument has an end effector, a shaft assembly, a body, and a power controller. The power controller is operatively connected to the ultrasonic blade and the RF electrode and configured to direct activation of the ultrasonic blade or the RF electrode. The power controller is further configured to interrogate the tissue with the electrical signal via the ultrasonic blade or the RF electrode to provide a tissue feedback and adjust an electrical parameter of the ultrasonic energy or the RF energy in response to the tissue feedback to inhibit transecting the tissue.

A system for performing ablation includes an ablation device (102) configured to ablate tissue in accordance with control parameters and configured to make measurements during the ablation process. An imaging system (104) is configured to measure an elastographic related parameter to monitor ablation progress. A parameter estimation and monitoring module (115) is configured to receive the measurements from the ablation device and/or the elastographic related parameter to provide feedback to adaptively adjust imaging parameters of the imaging device at different times during an ablation process.

An ultrasonic surgical instrument and method of sealing a tissue based on a production clamp force includes determining an ultrasonic seal process with the controller based on the production clamp force between an upper jaw and a lower jaw of an end effector and activating the ultrasonic energy or RF energy according to the determined ultrasonic seal process. The ultrasonic surgical instrument further includes an end effector having an ultrasonic blade, a jaw, an RF electrode, and a controller. The jaw is movably positioned relative to the ultrasonic blade and configured to move between an open position and a closed position and clamp together with a production clamp force in the closed position. The controller operatively connects to the ultrasonic blade and the RF electrode and includes the ultrasonic seal process based on the production clamp force stored thereon for driving the ultrasonic blade or the RF electrode.

A catheter assembly includes a catheter comprising a flexible elongated member including a distal portion that includes a tubular body defining an inner lumen and a plurality of body apertures that extend through a sidewall of the tubular body into the inner lumen, and a plurality of primary electrodes positioned along the tubular body. The catheter assembly includes a wire defining at least one secondary electrode, the wire being configured to be slidably moved through the inner lumen of the tubular body, where the wire and the plurality of primary electrodes are configured to electrically couple to an energy source that delivers an electrical pulse to a fluid in contact with the plurality of primary electrodes and the at least one secondary electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

An irreversible electroporation (IRE) method includes selecting electrodes of a catheter placed in contact with tissue in an organ, for applying IRE pulses between the selected electrodes. An impedance is measured between the selected electrodes. Based on the measured impedance, an IRE protocol is chosen, that has parameters that meet a predefined safety criterion under the measured impedance. The IRE pulses are applied according to the chosen protocol.

A medical device may include an elongated body having a distal elongated body portion and a central longitudinal axis. The medical device may include a balloon positioned along the distal elongated body portion. The balloon may be configured to receive a fluid to inflate the balloon such that an exterior balloon surface contacts a calcified lesion within a patient's vasculature. The medical device may include one or more pressure wave emitters positioned along the central longitudinal axis of the elongated body. The one or more pressure wave emitters may be configured to propagate at least one pressure wave through the fluid to fragment the calcified lesion. At least one pressure wave emitter may include an optical fiber configured to transmit laser energy into the balloon. The laser energy may be configured to create a cavitation bubble in the fluid.