An example medical system for ablating and occluding the left atrial appendage is disclosed. The example system includes a catheter sized and shaped for vascular access and including an elongate body extending between a proximal end and a distal end. A first expandable member may be positioned near the distal end of the elongate body and have a first region configured to permeate a liquid therethrough. A first set of one or more electrodes may be arranged within the first expandable member and may be configured to deliver energy to the tissue region. An occlusive implant may be releasably secured to the distal end of the elongate body.

An endovascular catheter combination configured to have multiple capabilities is disclosed. These capabilities include proximal and distal occlusion of a segment of a target blood vessel (such as the carotid artery) thus excluding the segment of the blood vessel from circulation for purposes such as surgical consideration. Another capability includes intravascular shunting of the blood through the excluded portion of the artery during a procedure such as an endarterectomy. Additionally, a microsensor provides a measurement of the rate/volume of blood flow through the distal end of the catheter. In one embodiment, a guidewire is provided with a filtration mesh as an anti-embolic mechanism both at the time of initial positioning of the catheter and after reversing the occlusion.

Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.

One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery.

Various systems and methods are provided for reducing pressure at an outflow of a duct such as the thoracic duct or the lymphatic duct. A catheter system can include a catheter shaft configured to be at least partially implantable within a patient's vein, a flexible membrane attached to the catheter shaft, the flexible membrane being a collapsible, tube-like member having a lumen extending therethrough, and a single selectively deployable restriction member formed over a portion of the flexible membrane at substantially a midpoint between a proximal end of the flexible membrane and a distal end of the flexible membrane, the restriction member being configured to control a size of the lumen so as to direct a controlled volume of fluid from an upstream side of the restriction member to a downstream side the restriction member.

A seal assembly for insertion into a hollow body organ is provided. The assembly includes a tubular hollow extrusion having a proximal end, a distal end and an interior surface between the proximal end and the distal end. A proximal balloon is located at the proximal end of the extrusion and a distal balloon is located at the distal end of the extrusion. An expandable scaffold engages the interior surface of the extrusion.

A system may comprise a first catheter having a first steerable segment and a second catheter disposed within the first catheter. The second catheter may have a second steerable segment. The system may also comprise an imaging element supported at a distal end of the second catheter, a coil reference sensor supported at a distal portion of the second catheter, and a processor in electrical communication with the coil reference sensor. The processor may be configured to determine a position of a distal portion of the first catheter with reference to the coil reference sensor.

Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state. The flow control assembly includes one or more components that interact with the blood flow through the shunt.

A catheter (1) and vein repair method that enables vein repair surgeries without any bleeding and without hindering blood flow in veins through bypassing the blood flow in the vein to be operated and by preventing any diseases arisen due to stop of blood flow of the organ fed by the associated vein and that sustains blood flow by means of vein bypass in the course of vascular surgeries implemented for surgical processes related to veins in human body and that comprises one balloon (3) on each point close to its both ends, protective layer (4) positioned on the balloons (3); second path (5) enabling deflation inflation of the balloons (3), having monolithic pipe shape adhered to the first path (2) side by side, whose one open end terminates within the balloon (3); check valve apparatus (7) that is monolithic with back end of the second path (5) and provides substances such as air and liquid with the injector for inflation deflation of the balloon (3); protective segment (6) surrounding externally the first path (2) and second path (5), thus preventing their blockage when compressed, that may have various lengths from back end of the balloon (3) to the backside of the catheter (1), that is monolithic along with the first path (2) and the second path (5); cover (8) that prevents the catheter apparatus (1) going out of the vein or its movement, that is located on body side of the catheter apparatus (1), positioned on back of the balloon (3), that can be moved over the catheter apparatus (1) as it is wider than body of the catheter apparatus (1), that has flexible structure having both ends open, that can have the shape of funnel or circle or ellipsis or different shapes; clamping apparatus (9) used to fix the cover on its relevant location; at least one third path (10) in the shape of pipe with both ends open, whose one end is positioned within first path (2), other end is located out of first path (2) and used to draw the liquid or air; connection apparatus (11) that is integrated with outer back end of third path (10) and that enables connection with the external injector and the catheters.

A method may include inflating a first balloon within an internal carotid artery so as to block antegrade flow of blood into an ophthalmic artery. Additionally, the method may include maintaining antegrade flow of blood in the internal carotid artery via a perfusion lumen in the first balloon. Further, the method may include inserting a device into the ophthalmic artery via a lumen extending through a portion of the first balloon to a side opening in the first balloon.