Improved methods and devices for performing an endoscopic surgery are provided. Systems are taught for operatively treating gastrointestinal disorders endoscopically in a stable, yet dynamic operative environment, and in a minimally-invasive manner. Such systems include, for example, an endoscopic surgical suite. The surgical suite can have a reversibly-expandable retractor that expands to provide a stable, operative environment within a subject. The expansion can be asymmetric around a stabilizer subsystem to maximize space for a tool and an endoscope to each be maneuvered independently to visualize a target tissue and treat the target tissue from outside the patient in a minimally invasive manner.

An apparatus and method for preventing stroke by occluding blood flow through the carotid arteries and a left subclavian artery of a patient is provided. The apparatus has a first occluding catheter that carries a first occluding balloon that has an inflated configuration that occludes one of the carotid arteries. The apparatus also includes a second occluding catheter that carries a second occluding balloon that has an inflated configuration that occludes the other one of the carotid arteries. A third occluding balloon is present, that could be on an insertion device, that may occlude the left subclavian artery.

Catheter devices and methods are disclosed and described. A catheter device (100) can include a longitudinal lumen (104) and having a proximal end (104a) and a distal end (104b). The distal end (104b) is capable of insertion into at least the internal carotid artery. The catheter device (100) can include an occlusion balloon (120b) connected to the distal end (104b) and operable to occlude blood flow in a blood vessel (102) by inflation and deflation using a pressurization fluid. The catheter device (100) can include a pressure sensor (110b) associated with the distal end (104b) and operable to measure blood pressure data from at least one of a downstream (103b) and upstream (103a) location of the occlusion balloon (120b) and transmit the blood pressure data to a controller (150). The occlusion balloon (120b) can be operable to inflate or deflate based on inflation control information. The catheter device (100) can be used to treat cerebral thrombectomy in a subject.

An apparatus and methods are provided for a double balloon vascular occlusion catheter. The double balloon vascular occlusion catheter includes a catheter for reaching an injury site within an artery. The catheter includes a central lumen for receiving a wire to guide the catheter to the injury site. A distal aspect of the double balloon vascular occlusion catheter includes proximal and distal balloons for being inflated on opposite sides of the injury site. A space between the balloons provides a blood occlusion segment of the catheter when the balloons are inflated. Inflation tubes and luer-locks at a proximal aspect of the double balloon vascular occlusion catheter enable inflation of the balloons. The double balloon vascular occlusion catheter may include a bidirectional lumen that causes unobstructed blood flow to bypass the blood occlusion segment.

The disclosure includes a vein ablation system, comprising a catheter having an elongated body. In some embodiments, the vein ablation system comprises an ablation device at a distal portion of the elongated body. According to some embodiments, the vein ablation system comprises a control device at a proximal portion of the elongated body. The control device may comprise an input mechanism configured to simultaneously control at least two of a longitudinal translation of the ablation device through a target vessel, a rotation of the ablation device about a central longitudinal axis, and an infusion of a chemical agent into the target vessel.

A treatment of obstructive lung disease includes aiming a condensable vapor towards the airway wall, causing a band-shaped lesion to grow to a depth into the airway wall. Ablation parameters are set to control the depth of the band-shaped lesion to encompass the epithelial layer and exclude the smooth muscle layer of the airway. A wide variety of configurations of the vapor delivery are described to create ablation patterns in the airways of the patient with particular emphasis on treating chronic bronchitis.

A treatment of obstructive lung disease includes aiming a condensable vapor towards the airway wall, causing a band-shaped lesion to grow to a depth into the airway wall. Ablation parameters are set to control the depth of the band-shaped lesion to encompass the epithelial layer and exclude the smooth muscle layer of the airway. A wide variety of configurations of the vapor delivery are described to create ablation patterns in the airways of the patient with particular emphasis on treating chronic bronchitis.

Disclosed herein are improved methods and apparatuses for providing hemostasis within a cavity defined by an internal surface of a bleeding tissue space. A catheter comprising a proximal end and a distal end may be advanced into the cavity through a proximal opening of the tissue space into the cavity. A distal balloon coupled to the catheter may be positioned adjacent a distal opening of the tissue space, and expanded to seal the distal opening. A hemostatic agent may be applied from the catheter to the internal surface of the tissue space to inhibit bleeding of the tissue space. The hemostatic agent may be applied without occluding the proximal opening, the distal opening, and a path extending therebetween with the hemostatic agent.

Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.

A vascular graft deployment tool may include a grip, an elongated mandrel positioned distal of the grip, a vascular graft, at least part of which is disposed coaxially about the mandrel, a sheath assembly including a distal sheath portion and a proximal sheath potion, wherein the distal sheath portion and the proximal sheath portion are configured to constrain the vascular graft against the mandrel in an insertion diameter and a actuator that is moveable relative to the grip and engages the sheath assembly, wherein operation of the actuator causes at least one of the distal sheath portion and the proximal sheath portion to separate longitudinally to free at least a portion of the vascular graft. Further, a vascular graft is expandable from an insertion state to a deployed state and at least two suture cuffs are located between opposed ends of the vascular graft.