An elongate resilient tube of a mesh of shape memory alloy is used to therapeutically occlude an opening in body tissue. The tube is compressible so that it can be delivered to the opening in the body within a catheter. The tube self-expands as it is released from the catheter to contiguously form, sequentially, the following shapes: an outer bell-shaped structure; an inner bell-shaped structure disposed within the outer bell-shaped structure to conformingly engage an inner side of the outer bell-shaped structure; a tubular connector having a diameter substantially smaller than the inner bell-shaped structure, the tubular connector extending away from an apex of the inner bell-shaped structure; an inner plate-shaped structure; an outer plate-shaped structure; and a releasable connector. The bell shape is placed on one side of the opening, and the plate shape is placed on the other side of the opening, the connector passing through the opening.

An occluding device apparatus includes an embolization coil with a distal end and a proximal end with an opening and an attacher that is threaded through the opening at the proximal end of the embolization coil. The apparatus further comprises a delivery kit for delivery of the embolization coil in a body cavity. The kit comprises a guide catheter for percutaneous introduction of the embolization coil and an inner catheter slidably disposed within the guide catheter during insertion. The inner catheter comprises a proximal end and a distal end. The inner catheter further includes a hub disposed adjacent the proximal end. The kit further comprises a guide wire slidably disposed within the inner catheter. The guide wire provides a path during insertion thereof within a body cavity. The kit further comprises a pushwire to advance the embolization coil through the inner catheter.

In various embodiments, a system for delivering an implantable device inside a body cavity includes: 1) a core cannula; 2) an access sheath; 3) an injection apparatus for filling the implantable device with one or more fluids; and 4) expanding members operatively connected to the core cannula for preventing the core cannula from advancing through a body orifice once the core cannula and expanding members exist the access sheath. According to particular embodiments, a distal end of the core cannula is pre-attached to the implantable device through a device locking member. In one or more embodiments, upon assessment, an injection apparatus is removed using an injection apparatus handle, the implantable device is detached from the core cannula via a device deployment handle (to be implanted), and the access sheath is removed.

Disclosed herein are devices, designs, methods of manufacturing and using medical devices comprising expandable bodies for treating saccular vascular aneurysms and occluding segments of blood vessels and other biological conduits. Exemplary expandable bodies include hollow gold structures that can be folded, wrapped, and compressed, joined to a delivery device, advanced to location in the body of patient in need of treatment, expanded by injection of a fluid into the central void, and separated from the delivery device, remaining in place in an open, expanded form without the addition of support structures to the central void. Other expandable bodies include coiled wires that can be loaded into delivery catheters and expelled from the delivery catheters using pusher devices. Also disclosed herein, are methods of using multiple medical devices and expandable bodies where the expandable bodies are placed adjacent to each other to occlude a saccular aneurysm.

An occlusive implant system may include a catheter having a lumen extending therethrough, a core wire slidably and rotatably disposed within the lumen, the core wire having a threaded member disposed at a distal end, and a medical implant having an expandable frame, an occlusive element disposed on the frame, and a threaded insert coupled to a proximal portion of the frame, wherein the threaded member is removably coupled to the threaded insert.

A device for delivering an occlusive element includes an elongate pusher member having a lumen. A locking member is disposed within the lumen of the elongate pusher member. A moveable elongate releasing member is disposed within the lumen of the elongate pusher member. A filament is secured to the distal end of the elongate releasing member. The occlusive member is locked to the elongate releasing member when the filament passes through a securing member on the occlusive member and is pinched or wedged between the looking member and the elongate releasing member. The occlusive element is in an unlocked state when the elongate releasing member is retracted proximally relative to the elongate pusher member. The filament, along with the elongate releasing member, are retracted proximally until the filament is detached or uncoupled from the securing member of the occlusive member.

An apparatus includes a transducer assembly including a transducer housing and an ultrasonic transducer disposed within the transducer housing. A transducer horn is disposed at least partially within the transducer housing and includes a probe coupling. A first probe includes a first coupler and a first elongate member coupled to the first coupler. The first coupler has a first coupling portion and a second coupling portion, and the first coupling portion is configured to be releasably coupled to the probe coupling of the transducer horn such that the first probe is coupled to the ultrasonic transducer. A second probe includes a second coupler and a second elongate member coupled to the second coupler. The second coupler has a third coupling portion releasably coupiable to the second coupling portion of the first coupler such that the second probe is coupled to the ultrasonic transducer.

A bristle device 8 for delivery into a body lumen comprises a longitudinally extending stem 1 and a plurality of bristles extending generally outwardly from the stem for anchoring the device in a body lumen. There may be at least two bristle segments 96 and there are flexible sections 95 between the segments 96. The flexible sections 95 articulate to enable the device to pass through a catheter placed in a tortuous anatomy or to be deployed in a curved vessel, or across a bifurcation. In some cases at least some of the bristle segments 96 are spaced-apart to accommodate bending of the bristles.

Embodiments of the present invention provide an improved vascular occlusion device for occlusion of a passageway, cavity, or the like. According to one embodiment, a medical device for occluding a left atrial appendage is provided. The medical device includes a first portion having at least one plane of occlusion that is configured to be positioned outside of the left atrial appendage, and a second portion having at least one plane of occlusion that is configured to be at least partially positioned within a cavity defined by the left atrial appendage.

A device for implantation in a left atrial appendage of the heart comprises docking station comprising a radially expansible element that is adjustable between a contracted orientation suitable for transluminal delivery and a deployed orientation configured to anchor within the left atrial appendage and fluidically isolate the left atrial appendage from the left atrium, the docking station also includes a recessed socket accessible from the left atrium through an opening, and a closure coving the opening. A modular active element is configured for detachable engagement within the recessed socket of the docking station. The modular active element comprises a treatment element configured to electrically stimulate heart tissue, thermally stimulate heart tissue, electroporate heart tissue, or deliver a substance into heart tissue or a chamber of the heart, or a sensing element configured to detect a parameter selected from temperature, pressure, electrical signal, heart rate, or respiratory rate.