An atrial appendage occluder capable of entering a half-released state by means of pushing a head-end fiber comprises: an occlude body (1); a head-end control fiber (2); and a tail-end control fiber (3). A head end of the occluder body (1) is connected to one end of the head-end control fiber (2) by means of a head-end threaded bushing (4). A tail end of the occluder body (1) is connected to one end of the tail-end control fiber (3) by means of a tail-end threaded bushing (5). The tail-end control fiber (3) is in the form of a hollow column. The other end of the head-end control fiber (2) sequentially passes through the tail-end threaded bushing (5) and the tail-end control fiber (3). The occluder body (1) is in a woven-net support structure, and has a shape preconfigured to match the structure of an atrial appendage after the occluder body (1) has been fully released. The occluder body (1) is in the form of a strip and disposed in an outer sheath (6) before being released. The occluder body (1) is in a half-release state after being pushed out of the outer sheath (6). The diameter of the occluder body (1) is changed by pushing or pulling the head-end control fiber (2, 3). The atrial appendage occluder can adjust its location in the atrial appendage, such that the occluder can be released precisely in a preset location.

A method is described for use at a valve of a heart of a subject, the valve having an annulus, and the heart having an atrium upstream of the valve. A distal end of a manipulator is transluminally advanced into the atrium. A first part of an implant that includes an elongated contracting member is anchored to a first site on the annulus using the manipulator. The distal end of the manipulator is then pointed at a second site on the annulus such that a central longitudinal axis of the manipulator is disposed at an angle of 45-90 degrees with respect to a surface of the annulus. A second part of the implant is then anchored to the second site using the manipulator. Subsequently, the first site and the second site are drawn together by applying tension to the contracting member. Other embodiments are also described.

A device for treating an aneurysm with a braided implant can include a delivery tube having a spiral groove on an outer surface of the delivery tube and a braided implant having a spiral segment. The spiral segment can engage the spiral groove as the braided implant is delivered to an aneurysm treatment site. At the treatment site, the braided implant can be implanted, and the delivery tube can be rotated to disengage the spiral segment from the spiral groove. Once released, the spiral segment can reshape to occlude the neck of the aneurysm.

Devices and methods for treatment of a patient’s vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Embodiments of the present invention provide an improved vascular occlusion device for occlusion of a passageway, cavity, or the like. According to one embodiment, a medical device for occluding a left atrial appendage is provided. The medical device includes a first portion having at least one plane of occlusion that is configured to be positioned outside of the left atrial appendage, and a second portion having at least one plane of occlusion that is configured to be at least partially positioned within a cavity defined by the left atrial appendage.

Devices, systems, and methods used to seal a treatment area to prevent embolic agents from migrating are described. The concept has particular benefit in allowing liquid embolic to be used with a variety of intravascular therapeutic applications, including for occluding aneurysms and arteriovenous malformations in the neurovasculature.

The present disclosure describes delivery cables for delivering a medical device. In one embodiment, a delivery cable includes a flexible inner core, a proximal outer coil, and a distal outer coil. The proximal outer coil has a first rigidity. The distal outer coil surrounds at least a portion of a distal section of the flexible inner core and has a second rigidity less than the first rigidity thereby, thereby reducing bias placed on the medical device by the delivery cable.

The present disclosure generally relates to devices, systems, and methods for ablating and occluding a body lumen or cavity, including those implementations for occluding the left atrial appendage of the heart. An example assembly includes a connector assembly having a connector assembly proximal end and a connector assembly distal end, the connector assembly proximal and distal ends being opposite ends of the connector assembly; and an expandable frame that is detachably disposed at the connector assembly distal end, the expandable frame having a plurality of deployment positions that includes a first deployed position in which the expandable frame is in a focal arrangement and a second deployed position in which the expandable frame is in a wide area arrangement; and where the connector assembly is operatively connected to the expandable frame and configured to facilitate moving the expandable frame between the plurality of deployment positions.

A flow control device (300, 324, 330) for a bronchial passageway including: a flow control valve (307, 335); a braided wire structural frame (303) expandable from a collapsed configuration to an expanded configuration, in the collapsed configuration the frame is an extended tube and in the collapsed configuration the frame includes a wall contact section (310), a middle support section (312) within the wall contact section, and a fold (311) between and connecting the wall contact section and the middle support section; and a sealing membrane (305) mounted to at least a distal portion of the structural frame, wherein the sealing membrane forms an enclosed wall defining at least a portion of an airflow passage through the flow control device, and the flow control valve is included in the airflow passage and extending inward from the enclosed wall and at least partially within the wall contact section.

Devices and methods for treatment of a patient's vasculature may include a resilient self-expanding permeable implant having a plurality of elongate filaments secured in a hub at a proximal end of the permeable implant. Each of the plurality of elongate filaments may have a diameter between about 0.0005 and about 0.005 inches. The implant includes at least some filaments consisting of nitinol and at least some composite filaments that are drawn filled tube wires comprising an external nitinol tube and a radiopaque material concentrically disposed within the external tube. The implant has at least about 40% composite filaments relative to a total number of filaments, and wherein a total number of filaments is about 10 to about 300.