Several embodiments are set forth of devices, systems and methods for modifying an atrial appendage such as a left atrial appendage (LAA). In one embodiment, a medical device includes a frame member and a tissue growth member. The frame member includes a unitary, seamless central portion having a plurality of struts defining a multi-cellular structure and an anchoring system, the plurality of struts extending between and configured to self-expand and directly bias the anchor system to anchor the frame member at least partially within the LAA. With this arrangement, the tissue growth member is attached to the frame member to occlude the LAA.

The invention relates to an aneurysm coil that is made up of a single wire of a noncircular cross-sectional shape. The wire is coiled in a helical configuration to have an outer surface and an inner surface. The outer surface of the wire does not have a round outer surface. The aneurysm coil of the present invention is designed to encourage cellular adhesion and tissue growth along the coil surface by employing a wire having a substantially non-circular cross sectional area, such as a T shape, a triangle, square, rectangle, oval, pentagon, hexagon, septagon, octagon, star, rhombus, as well as a variety of non-geometric shapes. The use of a wire having such a cross sectional shape promotes endothelial cells to adhere and grow within the gaps created by the juxtaposition of the wire forming a coil, thus anchoring the coil to its intended location, promoting thrombosis, endothelial growth across the opening of the aneurysm, and eventual healing of the aneurysm.

A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.

Devices, systems and methods are provided for performing embolization procedures in a desired area of the body. Systems include embodiments of embolization devices having increased durability, flexibility, conformability and surface area that include elongate primary coils that are formed from helically wound elongate initial coils which are formed from helically wound metallic wire and delivery systems used to position the embolization devices at a target location within a lumen of a mammal.

This disclosure concerns systems and methods for tissue volume reduction and control of the flow of substances through the body. Systems according to the various embodiments of the disclosure include check valves formed from wire coils which are deployable through a tubular lumen, such as the working channel of an endoscope, or a catheter.

A device for occluding a vasculature of a patient including a micrograft having an absorbent polymeric structure with a lumen of transporting blood. The micrograft has a series of peaks and valleys formed by crimping. The occluding device is sufficiently small and flexible to be tracked on a guidewire and/or pushed through a microcatheter to a site within the vasculature of the patient. Delivery systems for delivering the micrografts are also disclosed.

An occlusion device delivery system can deliver an implant using a catheter. A distal section of the catheter has proximal and distal apertures extending through a wall of the catheter. The implant can be wound about the distal section and secured to the catheter via an engagement mechanism. The implant has a proximal segment that curves inwardly across the proximal aperture and a distal segment that curves inwardly across the distal aperture. The engagement mechanism engages the proximal and distal segments within their respective apertures to secure the implant to the catheter.

An implant may include a frame and a cover to facilitate endoluminal vessel occlusion, selective release of embolic material toward a target region, and/or endoluminal stenting. The frame of the implant provides radial expansion properties to secure the cover within a body vessel. The cover and/or the frame can occlude flow of a fluid through the body vessel.

Occlusive implants are provided with various embodiments of active and/or passive release structures. Systems for delivering the occlusive implants as well as methods for making and delivering the implants are also provided.

Devices and methods are described for occluding the left atrial appendage (LAA). The device excludes the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. The implantable device is delivered via transcatheter delivery into the LAA and secured within the LAA. The implant comprises an expandable and compliant frame and an expandable and conformable tubular foam body. The device may have a thromboresistant cover at a proximal end. The frame may have recapture struts inclining radially outwardly from a central hub. The frame may have axially extending side wall struts, with adjacent pairs of side wall struts joined at one or more apexes. Anchors extend from the frame and into the foam to engage tissue.