An intrasaccular flow diverter includes a wire structure (e.g., a braided wire or a laser-cut hypotube), a thin-film mesh placed over the wire structure, and crimps fixing the thin-film mesh to the wire structure at each crimp. The wire structure and the thin-film mesh between adjacent crimps are expanded radially to form thin-film covered spheroid structures. When deployed in an aneurysm, the spheroid structures may volumetrically fill the aneurysm sac. An intrasaccular flow diverter with an umbrella structure includes a wire structure with a plurality of crimps along the wire structure, and a thin-film covered umbrella structure at one end of the wire structure. The wire structure between adjacent crimps is expanded radially to form a spheroid structure. When deployed in an aneurysm, the thin-film covered umbrella structure may cover the aneurysm neck.

Systems for treating an aneurysm in a cerebral vessel and methods of use are described. In one embodiment, the system includes an elongate tubular member having a lumen, an expandable stent, and a delivery device. The expandable stent has a constrained state that is configured for delivery through the lumen of the elongate tubular member, and an expanded state configured for placement within the cerebral vessel adjacent the aneurysm. The delivery device includes an elongate member and a self-expandable portion. The proximal end of the self-expandable portion is coupled to the elongate member at or near the distal end of the elongate member. The self-expandable portion of the delivery device includes a tubular mesh structure having a constrained state and an expanded state. The stent is engaged (e.g., mechanical, frictional, or intermeshing) with the self-expandable portion of the delivery device.

System for inserting a self-expandable occluder (12) into a patient and for releasing the occluder (12) in the left atrial appendage (10) of the patient, the system including an insertion unit (100) which has a drive unit (102) and an insertion catheter including an outer tube and an inner tube extending through the outer tube, wherein a proximal end region of the occluder is movement-coupled to the outer tube, and wherein a distal end region of the occluder, is movement-coupled to the inner tube, wherein, in order to release the occluder, the drive unit interacts with the inner tube and the outer tube such that, when actuated, the inner tube can be moved in a distal or proximal direction and the outer tube can be moved in the proximal direction or distal direction, so that the distal end and the proximal end of the occluder can be moved away from or toward one another.

Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a medical device coupled to a delivery catheter includes a fluid flow path that facilitates contrast fluid to pass through the delivery catheter and the medical device to a distal side thereof to provide imaging information as to the position of the medical device positioned in the opening, such as the left atrial appendage. In another embodiment, a medical device is coupled to a delivery catheter, the medical device including flaps adjacent a hub of the medical device that close-off a bore of the hub upon the catheter being detached from the medical device.

A left atrial appendage occluder for improving sealing effect and a manufacturing method thereof are provided. The left atrial appendage occluder includes a sealing portion and an anchoring portion coupled to the sealing portion. The sealing portion and the anchoring portion abut against each other. A tight connection between the sealing portion and the anchoring portion can be achieved by applying a pre-tightening force, such that the left atrial appendage occluder can be better attached to and occlude the left atrial appendage after being release.

An implant for occluding a left atrial appendage may include an expandable framework including a body portion and a disk portion, wherein the expandable framework is configured to shift between a collapsed configuration and an expanded configuration, and an occlusive disk element disposed within the disk portion. The disk portion may include a first disk portion integrally formed with the body portion, and a second disk portion movably attached to the first disk portion by at least one hinge member.

The invention relates to a novel multivalent atrial appendage occluder of hybrid design based on two different atrial appendage occluders, one having a proximal disk-shaped cover and a second version without a proximal cover. The two occluder variants each provide relevant application solutions by themselves. The invention further relates to multiple specified, universal devices composed of predominantly rotationally symmetrical individual parts for producing these different LAA occluders (LAA=Left Atrial Appendage) which are graded in different sizes, for the interventional, catheter-based closure of the left atrial appendage. Axially and radially oriented hooks support the secure and gentle anchoring of the occluders 1 in the retaining area of the atrial appendage 26. As a result, the use of substantially smaller access ports in the interventional application is possible. The two atrial appendage occluder variants, with and without proximal cover 14, can be inserted using the same controllable access port and can be implanted in various sizes individually or in combination with one another and likewise as a hybrid variant of two occluders, one without a proximal cover (14) and one subsequently with a proximal cover (14) in one and the same atrial appendage (24) as shown in FIG. 17. The two atrial appendage occluder variants can each be released during the implantation phase in three stages until they are fully unfolded.

A left atrial appendage (LAA) occluder and an occluding system are provided. The LAA occluder includes a sealing portion and an ablation portion arranged in the sealing portion, as well as a hollow proximal connector at a proximal end of the sealing portion. The ablation portion is connected to the proximal connector. The ablation portion is used to freeze an LAA after being injected with cryogen so as to form an annular isolation band on an inner wall of the LAA for blocking the conduction of electrical signals between the LAA and a left atrium.

Devices and methods for treating vascular defects, such as, for example, balloon-type aneurysms, are described herein. In one embodiment, an apparatus includes an insertion portion and an expandable implant. The expandable implant is configured to be deployed in an aneurysm and is coupled to the insertion portion. The expandable implant has a first portion and a second portion coupled to the first portion. The expandable implant is movable between a first configuration in which the first portion and the second portion are substantially linearly aligned and a second configuration in which the second portion at least partially overlaps the first portion.

Devices, methods, and systems for closure device for a left atrial appendage and, in particular, to a closure device that includes an anchor element and a disc element that are each individually chosen based on the anatomy of the patient's left atrial appendage and assembled before implantation. In one embodiment, a medical device comprises: an anchor element, the anchor element including a first connection element; and a disc element, the disc element including a second connection element pivotably coupled to the first connection element, the anchor element being sized to be received and retained within a left atrial appendage and the disc element being sized to completely cover an opening of the left atrial appendage.