Manifolds and methods of operating manifolds are provided. An example manifold for controlling multi-lumen devices is provided that includes a substance supply mechanism. The substance supply mechanism independently provides a substance to, or remove a substance from, each of a plurality of lumens. The example manifold also includes a lumen selection mechanism. The lumen selection mechanism selectively opens and closes a connection between the substance supply mechanism and at least one of the plurality of lumens. A corresponding method of operation is also provided. An example embodiment also includes a manifold for use with a vessel seclusion device.

An endovascular system includes inner and outer catheters, a handle system operably coupled one end of the catheters, and a microvalve coupled to the other end of the catheters. The microvalve is constrained in a radially-collapsed closed configuration for advancement within a vessel to a treatment site. The handle system is operable to displace the inner and outer catheters portions relative to each other to move the microvalve between closed and open configurations. An indicator is provided to visually indicate the extent by which the microvalve is opened within the vessel.

Methods, devices and systems are described for treating venous insufficiency in which the vein is compressed at least partially along a treatment zone. A system can be provided including an injection device, such as a glue gun, that is operably connected to a delivery catheter that can be advanced across a treatment zone in the vein. The delivery catheter can be used to deliver one, two, or more boluses of media (e.g., cyanoacrylate) to occlude the vein along different spaced-apart sections of the treatment zone. External compression can also be applied to the vein by a compression element, such as a hand or multifunctional ultrasound transducer, to occlude portions of the vein along the treatment zone prior to or during the introduction of the boluses of media.

Devices, assemblies, systems, and techniques described herein may facilitate the delivery of medical fluid, such as an adhesive, to a patient. For example, a medical assembly may include a flexible catheter configured to be disposed within an anatomical structure of a patient, wherein the flexible catheter defines a lumen configured to contain a volume of medical adhesive. The medical assembly may also include a shaft defining a shaft cross-sectional dimension smaller than a lumen cross-sectional dimension of the lumen, wherein advancement of the shaft through at least a portion of the lumen forces at least a portion of the volume of medical adhesive out of the distal opening of the lumen of the flexible catheter.

A detachable tip sheathed balloon microcatheter is provided for delivering an embolic agent to a target location for the embolization of an arteriovenous malformation (AVM). The detachable tip sheathed balloon microcatheter including a balloon microcatheter including a first shaft and an inflatable balloon that is coupled to a distal end portion of the first shaft; and a detachable tip assembly that is configured to be detachably coupled to the first shaft of the balloon microcatheter. The detachable tip assembly includes a protective balloon sheath that is coupled to a proximal end portion of the second shaft, wherein when the detachable tip assembly is coupled to the balloon microcatheter, the protective balloon sheath surrounds at least a portion of the inflatable balloon.

An implant can include a frame and a mesh component coupled to the frame. The mesh component can define a first porosity, and the frame can define a frame porosity. The combined porosity of the mesh component and the frame can restrict blood flow into the implant.

This invention is an intrasacular aneurysm occlusion device with a proximal stent which is expanded to a globular shape within an aneurysm sac and then compressed into a bowl shape which covers the aneurysm neck. The device further comprises embolic members and/or embolic material which is inserted into a distal portion of the aneurysm sac. The proximal stent component covers the aneurysm neck so as to reduce blood flow into the aneurysm sac and the accumulated embolic members and/or embolic material in the distal portion of the aneurysm sac keeps the proximal stent in place.

Devices, systems, and methods for treating the pancreas are disclosed herein. For example, some aspects of the technology are directed to a method for treating a medical condition affecting the pancreas of a human patient, wherein the method comprises implanting an occlusive device within the pancreatic duct to induce atrophy of pancreatic tissue.

A medical device and methods of use are disclosed herein. The medical device includes a base microcatheter and a microcatheter tip assembly detachably coupled to a first end of the base microcatheter. The microcatheter tip assembly includes a body defining at least one lateral hole and a loading region, and an opening in a first end of the microcatheter tip assembly. The medical device includes a membrane carrier disposed within the loading region of the microcatheter tip assembly. The membrane carrier includes a body defining an opening, and a membrane covering the opening in the membrane carrier. The membrane is configured to rupture in response to a force applied to the membrane. When the membrane is disposed within the loading region of the microcatheter tip assembly and the membrane is not ruptured, the membrane is configured to prevent the flow of material through the opening in the first end of the microcatheter tip assembly.

Systems and methods of blocking a biological vessel 2 are provided. The systems and methods may comprise introducing to the vessel an amphiphilic peptide. The peptide may comprise at least thirteen amino acids that may alternate between a hydrophobic amino acid and a hydrophilic amino acid. The peptide may form a beta- sheet spontaneously in an aqueous solution in the presence of a cation.