Intrasaccular devices and methods of implanting the devices in an aneurysm are described. The device includes an expandable body comprising a plurality of elongate filamentary elements each having a first and a second end. Each of the plurality of elongate filamentary elements extends from a first end of the device to a second end of the device and back to the first end of the device. The first and second ends of each of the plurality of elongate members are coupled at the first end of the device in a hub. The device may further include a defect spanning structure made of a mesh. The defect spanning structure may be located around a proximal portion of the expandable body, and may be disposed exteriorly to an outer surface of the expandable body

A medical instrument set includes a embolic device loading catheter that includes a catheter body including a loading lumen having an open distal end, and a proximal hub including an insertion passage communicating with a proximal end of the loading lumen, and in which an embolic device is loaded in the loading lumen; and a delivery pusher that includes an elongated pusher body insertable into the loading lumen through the insertion passage of the proximal hub of the embolic device loading catheter. The catheter body includes a distal connection portion attachable to and detachable from a sheath hub on a distal side of the catheter body. The pusher body has a body length longer than a distance from a proximal end of the insertion passage of the proximal hub to a distal end opening of a sheath communicating with a sheath lumen of a delivery catheter.

Devices, systems, and methods used to seal a treatment area to prevent embolic agents from migrating are described. The concept has particular benefit in allowing liquid embolic to be used with a variety of intravascular therapeutic applications, including for occluding aneurysms and arteriovenous malformations in the neurovasculature.

An intranasal occlusion device having an inflatable balloon within a sponge that is used to prevent drainage of fluid, such as blood and other fluids into the airway during sinus and nasal minor procedures or surgeries, and methods of using the device to occlude an intranasal cavity of a patient. The device provides for suction to remove the fluid and may facilitate office-based minor procedures or surgeries.

Medical devices and methods are provided. In some aspects, devices useful for applying therapy locally within a body vessel are disclosed, the devices having a stent graft with flared end regions with a catheter providing fluid communication to the outer side of the narrower, intermediate region of the stent graft. Kits and systems including the same devices and methods are also disclosed.

The present teachings provide methods for resizing, reducing, and closing left atrial appendage. Specifically, a percutaneous trans-septal access is first established from outside the body to a patient's LAA. At least two tissue anchors are then implanted inside the LAA chamber and along the tissue wall. At least one anchor is implanted near the opening of the LAA camber. Both tissue anchors are pulled together so that the wall of the LAA chamber collapse. The LAA chamber is therefore resized, reduced, and/or closed off completely. This closure method and system could be used alone in closing LAA chamber. This closure method and system could also be used in addition to other treatment mechanisms, such as filling the LAA chamber with space-filling material, then closing off its opening.

An occlusion device having a support structure and an expandable occlusion element associated with the support structure. The expandable occlusion element is formed of a self-expanding material, such as a hydrogel. A retainer may be provided to hold the expandable occlusion element with respect to the support structure of the occlusion device, within or outside the support structure, and positioned such that expansion of the expandable occlusion element occludes a lumen through the support structure and the occlusion device. Expansion of the expandable occlusion element may be reversible, or the expandable occlusion element may be releasable from the support structure.

Implants comprising electrically-responsive hydrogel are described. Systems to provide electricity to induce response in hydrogel-containing implants are described. Methods for utilizing said system and methods for utilizing said hydrogel-containing implants are described.

Embodiments include, for example, mechanical release systems for implantable medical devices.

Several embodiments are set forth of devices, systems and methods for modifying an atrial appendage such as a left atrial appendage (LAA). In one embodiment, a medical device includes a frame member and a tissue growth member. The frame member includes a unitary, seamless central portion having a plurality of struts defining a multi-cellular structure and an anchoring system, the plurality of struts extending between and configured to self-expand and directly bias the anchor system to anchor the frame member at least partially within the LAA. With this arrangement, the tissue growth member is attached to the frame member to occlude the LAA.