According to some embodiments there is provided a method for controlling a treatment effect on blood vessel tissue during an ultrasonic treatment, the method comprising positioning an ultrasonic transducer device in the blood vessel lumen; controlling a treatment effect by controlling fluid flow, wherein controlling comprises deploying a fluid restrictor at a location relative to the transducer effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. According to some embodiments there is provided an ultrasonic transducer device sized for placement in a body lumen, and comprising a fluid restrictor effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. In some embodiments, the fluid is blood.

Nanoparticles are suspended in a fluid medium which is activated using an ultrasonic transducer in contact with the fluid medium. The fluid may be injected into a body cavity and ultrasonically activated to induce a cavitation effect. The body cavity may contain a natural or artificial hard surface, inflamed or with a biofilm harnessing bacteria, such as a bone, joint or implant, as well as the surrounding tissue. In an embodiment, a treatment device may be used before, during or after a procedure such as a minimally invasive or open surgery to disinfect the body cavity via irrigation with liquid containing suspended nanoparticles and ultrasonically activated. The irrigation device may supply the cavity with the liquid and include therein an ultrasonic transducer. The cleaning and disinfecting process may be performed as treatment of infection in absence of another surgical procedure.

An ultrasonic treatment tool comprises: a blade including a treatment portion, the treatment portion is configured to treat a treatment target and the blade is configured to transmit an ultrasonic vibration to the treatment portion, a pattern on at least part of an outer surface of the treatment portion, the pattern including a plurality of protrusions, each protrusion includes at least one side surface intersecting with a vibration direction of the ultrasonic vibration, the at least one side surface defining a cavitation surface, at least one cavitation surface is located within a pitch width in the vibration direction, an amplitude of the ultrasonic vibration defines the pitch width.

The present disclosure relates generally to thrombectomy devices. An exemplary catheter comprises: a central tube; an emitter assembly mounted over the central tube, wherein the emitter assembly comprises: a conductive sheath; a first insulated wire having a first curved distal portion; and a second insulated wire having a second curved distal portion, wherein the first curved distal portion and the second curved distal portion are positioned within the conductive sheath, and wherein the emitter assembly is configured to generate a plurality of cavitation bubbles or shockwaves when a pulsed voltage is applied to the emitter assembly; and an outer tube housing the emitter assembly, wherein the outer tube is configured to receive a conductive fluid, wherein the outer tube comprises a distal opening for releasing the plurality of cavitation bubbles or shockwaves and the conductive fluid in a forward direction to treat thrombus at a treatment site.

A wireless magnetic ultrasonic cavitation in-vivo therapeutic robotic device, including a micro-robot and an in-vitro control device; the in-vitro control device has an outer housing in which provided with electromagnetic coils and wireless power emitting coils; the micro-robot has a capsule shaped housing in which a super magnetic module is provided; a micro ultrasonic vibrator and a micro wireless power receiving coil electronically connected with each other are provided inside the housing; the wireless power emitting coils emit electromagnetic field to the micro wireless power receiving coil, which receives and then transforms the electromagnetic field to electrical current to supply power to the micro ultrasonic vibrator. The robotic device creates ultrasonic cavitation effect in the blood, causing rapid vibration of blood cells, which enhances cell regeneration power, burn blood lipids, clear blood clots and ensures good condition of blood vessels.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

This invention relates generally to an ultrasound device configured to generate a frustum-shaped beam capable of fragmenting a plurality of biomineralizations located within a patient's body in combination with synthetic cavitation nuclei. The ultrasound device includes a transducer assembly comprising a plurality of ultrasound transducer elements, and a multi-channel amplifier circuit. Each channel of the multi-channel amplifier circuit is configured to actuate a distinct subset of the plurality of transducer elements. The multi-channel amplifier circuit is configured to operate in each of a plurality of states, each state of comprising a set of frequencies at which each channel of the multi-channel amplifier circuit is configured to actuate the distinct subset of transducer elements. The multi-channel amplifier circuit is further configured to switch between the plurality of states, thereby causing the plurality of ultrasound transducer elements to produce a frustum-shaped beam.

A device for therapeutic ablative treatment of residual plaque on, in, and/or surrounding a stent within a blood vessel of a subject includes a jacket configured for insertion within a stent within a blood vessel of a subject. The device further includes an ultrasound transducer located within the jacket and having at least one active element oriented to deliver ultrasound energy in a radial and/or axial direction of the jacket from within the stent to ablate the residual plaque.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.