In one example embodiment, an apparatus for treating a tissue site may include a contact layer formed from a compressible material. The contact layer may include a plurality of apertures extending at least partially through the contact layer. The contact layer may be configurable such that at least a portion of the apertures include a first plurality of orifices having a diameter in a first diameter range and such that at least a portion of the apertures include a second plurality of orifices having a diameter in a second diameter range. The first diameter range may be from about 2 mm to about 6 mm. The second diameter range may be from about 8 mm to about 15 mm. The apparatus may include a cover configured to form a sealed space including the contact layer and the tissue site.

A system and method for ultrasound treatment is presented. The system and method alternatingly provide microbubbles in a target region containing a biomineralization, then insonate the microbubbles using an external ultrasound source. The microbubbles cavitate in the target region, destructively affecting the biomineralization and potentially breaking it or reducing its mass over time as a result of the cavitation action. Spatial orientation or alignment of the external ultrasound source may be achieved for best results using acoustic signatures and spectral representations of the same.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

A method for using metastable perfluorocarbon nanodroplets for ultrasonic lysis of blood clots includes administering metastable perfluorocarbon nanodroplets into a blood vessel that includes or that leads to a blood vessel that includes a blood clot, the metastable perfluorocarbon nanodroplets each have a liquid core comprising a perfluorocarbon material that has a boiling point below 25 C. at atmospheric pressure and that remains stable in liquid form at 25 C. at atmospheric pressure. The method further includes applying ultrasound energy to the perfluorocarbon nanodroplets within or surrounding the blood clot, causing the perfluorocarbon nanodroplets to vaporize and convert to bubbles, which cavitate and lyse the blood clot.

Disclosed herein are the systems, devices and methods for treating cancer and metastasis using low energy immune priming. The low energy immune priming includes administering immunopriming energy. The low energy immune priming can be combined with an adjunct therapy.

Medical devices and method for making and using medical devices are disclosed. An example method for treating a blood vessel may include disposing a medical device within the blood vessel at a position adjacent to a lesion. The medical device may include an elongate shaft having a distal end region, a balloon coupled to the distal end region, and a cavitation member disposed within the balloon. The method may also include inflating the balloon to a first pressure, activating the cavitation member, and inflating the balloon to a second pressure greater than the first pressure.

A lithotripter tip configured for use within an invasive lithotripter probe may include a lithotripter tip body defining an interior region in communication with an aperture at a distal end of the lithotripter tip body and defining at least one port in communication with the interior region. A first electrode and a second electrode are positioned within the interior region of the lithotripter tip such that such that when liquid is within the interior region and an electric arc occurs between the first and second electrodes, a gaseous bubble forms within the interior region and a resulting shockwave travels out of the aperture at the distal end of the lithotripter tip body.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

A method and apparatus for disrupting material at a tissue site is described. A contact layer may be selected for use on the tissue site and positioned adjacent to the tissue site. The contact layer may include walls defining a plurality of through-holes. A sealing member may be positioned over the contact layer and sealed to tissue surrounding the tissue site to form a sealed space enclosing the contact layer. A negative-pressure source may be fluidly coupled to the sealed space. The negative-pressure source may supply negative pressure to the sealed space and the contact layer to draw tissue into the through-holes to form nodules. The negative pressure may be vented from the sealed space to release the nodules.