A device for delivering mechanical waves to treat a lesion present in a blood vessel, including a catheter extending between a first proximal end and a first distal end, an inflatable balloon secured to the catheter and being adjustable between an inflated configuration and a deflated configuration, and at least one mechanical waveguide extending between a second proximal end and a second distal end for propagating at least one mechanical wave from the second proximal end to the second distal, with the mechanical waveguide being secured to the inflatable balloon or the catheter.

An ultrasonic catheter is disclosed. The ultrasonic catheter comprises a body having a longitudinal axis and a distal end. A Piezoelectric Micromachined Ultrasonic Transducer (pMUT) array is disposed within the distal end of the body. Further, the pMUT array comprises a plurality of pMUT array elements arranged on a substrate. Further, an insulating material is disposed at the distal end over an imaging window, to provide electrical isolation and transmission of ultrasound signals. The insulating material corresponds to a polyether block amide (PEBA) or Pebax, or thermoplastic elastomer (TPE).

There is described a method of treating a lesion including inserting a waveguide into a vessel of a subject, with a lesion being present in the vessel and the waveguide extending longitudinally between a proximal end and a distal end; positioning the distal end of the waveguide adjacent to the lesion; generating a high amplitude mechanical pulse and propagating the high amplitude pulse from the proximal end to the distal end of the waveguide; and propagating at least a portion of the high amplitude pulse from the distal end of the waveguide to the lesion, the at least one portion of the high amplitude pulse propagating up to the lesion, thereby treating at least partially the lesion.

Methods and devices are provided for vessel preparation to facilitate adjunctive therapies including the delivery of therapeutic drugs. An ultrasound catheter is provided, which has an ultrasound transmission member or wire with an affixed tip on the distal end, and an attached sonic connector on the proximal end extending through the catheter shaft which has a distal end coaxially positioned inside the tip and affixed to the tip. The ultrasound device propagates ultrasound energy while undergoing irrigation.

Various embodiments described herein are directed to ultrasonic blades. For example, an ultrasonic blade may comprise a proximally positioned straight section extending along a longitudinal axis and a distally positioned curved section coupled to the straight section and curved away from the longitudinal axis. The curved section may define a radius of curvature and subtend a first angle. A point of tangency between the curved section and the straight section may be positioned at either a node of the ultrasonic blade or an anti-node of the ultrasonic blade.

An ultrasonic catheter includes a body and an ultrasound transmission member disposed in the body. A head is coupled to the ultrasound transmission member, wherein a gap separates the head from a body distal end. A guidewire tube extends through the body and the head. A proximal end connector assembly includes a hub and an absorber member. The hub has a bore coupled to and in fluid communication with the body. The absorber member is disposed within the bore around the ultrasound transmission member. A sonic connector is disposed between the ultrasound transmission member and a separate generator.

An ultrasonic horn, an ultrasonic transducer assembly including the same, and an ultrasonic surgical instrument including the same. The ultrasonic horn includes a body and a nose. The body defines a length and a maximum diameter of the ultrasonic horn. The body includes at least one depression arranged annularly thereabout that is configured to receive at least one protrusion for mounting the body within a support structure. The nose extends distally from the body. The body defines a proximal connector configured to enable the body to be secured to a piezoelectric stack and the nose defines a distal connector configured to enable the nose to be engaged with a waveguide for transmission of ultrasonic energy produced by the piezoelectric stack to the waveguide.

An ultrasonic horn for an ultrasonic transducer assembly of an ultrasonic surgical instrument includes a body and a nose. The body defines a tubular configuration having a hollow interior and a plurality of slots therethrough extending into the hollow interior. The nose extends distally from the body. The body defines a proximal connector configured to enable the body to be secured to a piezoelectric stack and the nose defines a distal connector configured to enable the nose to be engaged with a waveguide for transmission of ultrasonic energy produced by the piezoelectric stack to the waveguide.

An arterial blockage percussive drill having a guiding sleeve, a drilling wire slidably coupled to the guiding sleeve and a percussive actuator coupled to the drilling wire to longitudinally oscillate the drilling wire into an arterial blockage.

A compound transmission member including: a first tube sub-member and a second tube sub-member, each including: a first end having a first opening and a second end having a second opening, wherein the first opening is in fluid communication with the second opening, and wherein at least the first tube sub-member is configured to transmit ultrasonic energy; and a fitting configured to receive the first ends of the tube sub-members.