Described herein are acoustic-based tissue treatment systems, apparatuses, and methods for use therewith. Certain such apparatuses comprise a catheter sized and shaped for delivery through a radial artery including a catheter shaft having distal and proximal ends, a plurality of lumens extending longitudinally through the catheter shaft between the distal and proximal ends thereof, and an ultrasound transducer distally positioned relative to the distal end of the catheter shaft. A balloon may surround the ultrasound transducer and at least one of the plurality of lumens may be configured to provide a cooling fluid to the balloon at a pressure and flow rate sufficient to protect non-target tissue in the blood vessel wall from thermal injury. In certain embodiments, the apparatus also includes a single electrical cable extending through one of the lumens and including first conductor(s) coupled to the first electrode of the ultrasound transducer, and second conductor(s) coupled to the second electrode of the ultrasound transducer. The single electrical cable may be configured to deliver sufficient electrical energy during sonication to the transducer such that the transducer thermally induces modulation of neural fibers surrounding the blood vessel sufficient to improve a measurable physiological parameter corresponding to a diagnosed condition of the patient.

Various devices related to a therapeutic ultrasound device for use during a medical procedure to cauterize tissue are disclosed. The therapeutic ultrasound device can include an inner tube assembly and an outer tube assembly. The device can further include a tissue engagement assembly that is secured to the distal end of the inner tube and the distal end of the outer tube. The tissue engagement assembly includes a plurality of transducers configured to provide therapeutic ultrasound. The device can include a housing assembly that is secured to the proximal end of the inner tube and the proximal end of the outer tube. The housing assembly can include a handle configured to actuate the inner tube relative to the outer tube to engage and disengage the tissue engagement assembly.

Apparatus and methods for creating tissue necrosis include an energy delivery apparatus that can be positioned adjacent a target treatment site such as a vessel without direct contact with the treatment site tissue. Collimated energy is then directed to the vessel to create necrotic regions in the tissue. Exemplary use in renal vessels creates necrotic regions in adjacent nerves which can alleviate hypertension in a patient.

Provided are products of manufacture and methods for the removal and/or destruction of a biofilm in situ, e.g., a gastro-luminal biofilm, and for the treatment or amelioration of biofilm-associated diseases, infections and conditions, including and GI luminal infections. Provided are devices and apparatus, and methods for using them, for the removal, disruption and/or destruction of a biofilm in situ, e.g., a gastro-luminal biofilm. In alternative embodiments, provided are devices and apparatus, and methods, for enhancing biofilm dissolving or disrupting agents, or for administering biofilm dissolving or disrupting agents, where in alternative embodiments the biofilm comprises a gastro-luminal ‘unstirred layer’, adherent layer or gastro-luminal mucus layer; or the biofilm comprises a matrix or a DNA-containing layer, or alternatively the biofilm comprises a polysaccharide gastro-luminal peripheral layer.

The present application provides an electrode catheter system, comprising an interventional catheter for intervening to one side of an artery blood vessel and provided with an electrode element that can release an electrical signal toward an inner wall of a renal artery blood vessel; a pressure sensor for intervening to an artery blood vessel; and a data processing module, connected with the pressure sensor. The electrode element releases an electrical signal toward the inner wall of the renal artery vessel, and then the pressure sensor monitors a blood pressure change in the renal artery vessel at the other side. A data processing module processes the data monitored by the pressure sensor and determines the blood pressure change, and an activity degree of the nerve can be determined by measuring a signal such as the blood pressure of the human body, so as to screen out the patients with an overactive sympathetic nerve, and a surgical effect of a denervation surgery can also be evaluated before or after the surgery, and can be used to determine whether to perform an ultrasonic ablation again.

The present invention provides a catheter for treating occlusions in blood vessels. An exemplary catheter for treating occlusions in blood vessels comprises a tubular inner member including a base segment with a first lumen defining a fluid inlet port, and a second lumen defining a fluid outlet port. An extension segment is distal to the base segment. The extension segment has a reduced cross-section. An emitter assembly includes a first insulated wire extending through the second lumen and a second insulated wire, and a conductive sheath wrapped circumferentially around the first insulated wire, the second insulated wire, and the extension segment. A cap or balloon is sealably attached to the distal end of the catheter and surrounds the emitter assembly, said cap or balloon being fillable with conductive fluid.

Devices, assemblies, systems, and techniques described herein may deliver a pressure wave to structures of a heart, such an aortic valve. For example, a medical assembly may include an expandable member configured to expand from a collapsed configuration to an expanded configuration, the expandable member configured to at least partially define a channel through the expandable member in the expanded configuration and one or more electrodes carried by the expandable member. The one or more electrodes may be configured to transmit an electrical signal through a fluid to cause the fluid to undergo cavitation that generates a pressure wave within the fluid.

Disclosed herein shock wave catheters comprising one or more shock wave electrodes for cracking calcifications located within blood vessels. In some variations, a shock wave catheter has first and second shock wave electrodes each circumferentially disposed over the outer surface of the catheter. In certain variations, the first electrode has a recess and the second electrode has a protrusion that is received by the recess and a spark gap is located along the separation between the recess and the protrusion. The second electrode can also have a recess that receives a protrusion from a third shock wave electrode, where the separation between the second and third electrodes along the separation between the recess and the protrusion forms a second spark gap. A shock wave can be initiated across these spark gaps when a voltage is applied over the electrodes.

Disclosed herein are medical systems and methods for ultrasonic decomposition of intraluminal clots. A medical system can include a stylet configured to insert into a lumen of a catheter. The stylet can include one or more electrical impedance sensors, as well as one or more ultrasound transducers or a resonant section of the stylet. The one-or-more impedance sensors can be configured to detect changes in impedance for identifying intraluminal clots in the catheter. The one-or-more ultrasound transducers can be configured for decomposing the intraluminal clots to reestablish patency in the catheter, while the resonant section of the stylet can be configured to resonate with an externally applied ultrasonic frequency for decomposing the intraluminal clots to reestablish patency in the catheter. The medical system can further include a console to which the stylet is connected in an operable state of the medical system.

A catheter system (100) for treating a vascular lesion (106A) within or adjacent to a vessel wall (108A) of a blood vessel (108) within a body (107) of a patient (109) includes a catheter shaft (210); a handle assembly (228); and a source manifold (236). The handle assembly (228) is coupled to the catheter shaft (210). The handle assembly (228) includes an assembly housing (266). The handle assembly (228) is usable by a user to selectively position the catheter shaft (210) near the vascular lesion (106A). The source manifold (236) is coupled to the assembly housing (266). The source manifold (236) includes a manifold housing (282) having a catheter shaft port (264) that is configured to receive a portion of the catheter shaft (210) so that the catheter shaft (210) is coupled to the manifold housing (282).