An irrigation balloon catheter includes one or more inner balloons inside of an irrigation balloon. The inner balloon(s) can be compliant with a volume that is dynamically adjustable for rapid inflation, rapid deflation, complete deflation, and/or irrigation flow adjustment.

A balloon catheter for an intravascular catheter system includes an outer inflatable balloon and an inner inflatable balloon that is positioned substantially within the outer inflatable balloon. At a nominal working balloon pressure, the outer inflatable balloon has an outer balloon diameter and the inner inflatable balloon has an inner balloon diameter that is greater than the outer balloon diameter at the nominal working balloon pressure. The inner balloon diameter can be at least approximately 5%, 10%, 15%, 20%, 25% or 30% greater than the outer balloon diameter. The inner balloon diameter can be between approximately 29-35 millimeters, and the outer balloon diameter can be between approximately 23-29 millimeters. The inner inflatable balloon can be less compliant than the outer inflatable balloon. The outer balloon compliance can be at least approximately 2%, 5%, 8%, 10%, 15% or 20% greater than the inner balloon compliance.

Devices and methods for creating radial-linear lesions in pulmonary vein antral tissue are disclosed. In an embodiment, a device includes an elongate shaft structure with a distal tip ablation region including a spline and an ablation element slidably coupled to the spline. The ablation element includes at least one of an ultrasound emitter, a high frequency ultrasound emitter, a laser, a radiofrequency electrode, a virtual radiofrequency electrode, or a cryogenic source. A backing balloon may be configured to push or pull the spline and the ablation element toward or against the pulmonary vein antral tissue. In an embodiment, the distal tip ablation region includes a splineless cryoballoon with at least one thermally conductive region.

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat at least one of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

A cryoballoon deflation assembly for an intravascular catheter system for use during a cryoablation procedure includes a first deflation initiator and a first deflation initiator inhibitor. The first deflation initiator is configured to automatically activate a vacuum pump to deflate a cryoballoon upon completion of a stage of the cryoablation procedure. The first deflation initiator inhibitor is manually changeable to between an activated and deactivated state. When in the activated state, the first deflation initiator inhibitor is configured to inactivate the first deflation initiator. The cryoballoon deflation assembly can further include a second deflation initiator. The second deflation initiator is manually changeable between an activated and deactivated state. When in the activated state, the second deflation initiator is triggered to activate the vacuum pump to deflate the cryoballoon.

The instant disclosure relates to electrophysiology catheters for tissue ablation. In particular, the instant disclosure relates to a cryogenic ablation balloon with safety features that facilitate identification of a leak into an interstitial space between inner and outer balloons as part of the ablation balloon catheter assembly, and prevents egress of cryogenic fluid out of the ablation balloon.

The instant disclosure relates to electrophysiology catheters for tissue ablation within a cardiac muscle. In particular, the instant disclosure relates to an ablation balloon and catheter shaft that deflects to conform to a shape of a target pulmonary vein receiving ablation therapy for a cardiac arrhythmia, for example. The deflection of the catheter shaft enables a lesion line along a circumference of the target pulmonary vein with improved consistency.

Cardiac ablation catheters include an outer balloon positioned at a distal end of the catheter and configured to have an inner balloon disposed therein. The outer balloon is inflated with a first fluid that has a temperature less than 100 degrees Celsius, while the inner balloon is inflated with heated vapor. An area of contact between the two balloons, comprising a surface area less than the total surface area of either balloon, creates a hot zone for ablating cardiac tissue through the transfer of thermal energy from the contact area to the cardiac tissue.