The present invention relates to a medical device for denervation of the renal perivascular nerves, with a catheter which comprises a flexible shaft for insertion in a patient's renal artery, wherein the shaft has an inner lumen for supplying a refrigerant and a cryoballoon arranged on the distal end of the shaft. At least one bipolar electrode is arranged on the cryoballoon to deliver an electrical pulse for stimulating the perivascular nerves. In order to guarantee ablation of the renal perivascular nerves over the entire length, the cryoballoon is embodied such that during application it touches the wall of the renal artery over a length of more than 2.5 cm in the direction of blood flow, and simultaneously ablates throughout at least 60% of its circumference and throughout a length of at least 2.5 cm.

An apparatus for gas-assisted electrosurgery having a gas-assisted electrosurgical probe comprising a tube and an electrode within said tube, wherein a distal end portion of said electrode extends from an opening at a distal end of said tube and an electrically insulating tip connected to a distal end of said electrode. The electrically insulating tip has a substantially hemispherical distal end portion having a radius r.sub.1 and a proximal portion having a circular cross-section and a central axis of a length l.sub.1, wherein 1.sub.1>r.sub.1.

A catheter for ablation of tissue through irreversible electroporation includes an electrode assembly comprising a flexible circuit having a distally located central flex circuit hub and a plurality of flex circuit branches extending proximally from the hub portion, each of the flex circuit branches defining, at least in part, an electrode assembly spline. The flexible circuit further includes a distal ablation electrode including an ablation electrode hub portion, and a plurality of radial segments integrally formed with the ablation electrode hub portion, each of the radial segments extending proximally along a portion of a respective one of the flex circuit branches and terminating in a proximal end, a plurality of proximal ablation electrodes, each of the proximal ablation electrodes located on a respective one of the flex circuit branches and having a distal end spaced from the proximal end of the adjacent radial segment of the distal ablation electrode.

A multi-electrode catheter is presented herein having a puller wire with a distal end bonded to a coupler tube between a catheter shaft body and end effector. Because the puller wire is bonded to the coupler tube, a distal portion of the catheter body shaft, at least up to a proximal end of the coupler tube, can be deflected when the puller wire is retracted. The coupler tube may also be flexible and be deflectable when the puller wire is retracted. The coupler tube may bend with a radius of curvature that is greater than, equal to, or less than a radius of curvature of the distal portion of the catheter body shaft, depending on design considerations of the catheter. The coupler tube may be made from a flexible material and/or may include sidewall slits which facilitate bending of the coupler tube.

A system for facilitating an ablation in a patient's heart is disclosed. The system includes a catheter and a controller. The catheter includes an electrode assembly having spaced-apart electrodes disposed on splines to generate an electric field in the heart, the splines configurable in an expanded position wherein the plurality of spaced-apart electrodes are in a selected spatial relationship, and wherein the splines are deformable relative to the expanded configuration when subjected to a force. The controller is configured to measure an electrical signal received from an electrode of the spaced-apart electrodes in response to the electric field, the electrical signal indicative of a parameter of the electric field, and the controller configured to determine a deformation of the splines relative to the expanded position based on the measured electrical signal.

In an illustrative embodiment, systems and methods for treatment of nerves present in a wall of a human renal pelvis are described. One system uses a sheath to access a position in or near the renal pelvis via the urinary tract. An effector inserted through the sheath has an uncooled distal region formed with a superelastic wire that supports at least four non-insulated, preferably spherical electrodes distributed along the distal region. The distal region expands within the renal pelvis, and vacuum applied through the sheath at least partially evacuates the renal pelvis to draw opposing walls of the renal pelvis inwards and compress the distal region somewhat from its expanded form, placing the electrodes in intimate contact with different points along the renal pelvic wall. Energy is applied to the electrodes to create discrete lesions at the points of contact of the electrodes.

The disclosed technology includes an end effector in a medical catheter including a woven mesh extending along a longitudinal axis from a proximal portion to a distal portion, the woven mesh defining a generally spheroidal shape having a plurality of electrodes disposed about the longitudinal axis and adjacent to an equator of the generally spheroidal shape with the proximal portion configured to be attached to a shaft and with the distal portion configured to be invaginated and coupled to an actuator extending along the longitudinal axis.

A medical device includes a sheath extending from a proximal end to a distal end and having a lumen extending therethrough and an end-effector disposed at the distal end of the sheath including a first resection loop configured to resect tissue and a secondary tool including one of a second resection loop and a tissue-vaporizing structure mounted distally to the first resection loop.

The present invention is directed to a medical device for providing treatment to diseased tissue and cells. The medical device is configured to ablate a target tissue surface, optionally within a resection cavity, and further deliver a therapeutic that targets diseased (e.g., cancer) cells via a marker whose expression is upregulated by the ablation. The ablation directly kills diseased cells associated with the tissue surface. While some diseased cells evade direct ablation, those cells nevertheless upregulate certain cell surface markers in response to the ablation, even while other, healthy or normal cells do not upregulate expression of the marker in response to the ablation. Devices and methods disclosed herein are used to deliver a therapeutic that uses the upregulated cell surface marker to cause the death of those diseased cells.

Dual-channel injection bipolar high frequency electrosurgical knife comprises an electrode part, a main part and an operation part. The electrode part comprises an active electrode, an insulating part and an inert electrode. The active electrode has a hollow tubular portion, which can cut the target lesion tissue when power on. The main part comprises a protective tube, an insulation sheath and an insulation coated screw, connector, seal. The insulation coated screw includes a conductive screw and an insulating coating on the surface. The operation part comprises a positioning structure, a slider, a core rod, a connection sheath, an infusion tube and a connection cable. 6% Luer tapers are attached to both the positioning structure and the infusion tube. Liquid can flow out from the dual-channel, a solution can be injected in submucosal layer to elevate the mucous membrane tissue or clean hemorrhage site.