A medical system having a medical tool, including a handle, a shaft extending from the handle and defining a lumen, a wire attached to and extending from the handle through the lumen, expandable elements at a distal end of the wire. An electrical generator is coupled to a proximal end of the wire and supplies a first waveform to the wire and the expandable elements as the expandable elements expand from an unexpanded state to an expanded state within a tissue. The electrical generator supplies a second waveform to the wire and the expandable elements when the expandable elements are in the expanded state within the tissue. The first waveform cuts tissue, the second waveform ablates tissue using radiofrequency ablation or irreversible electroporation.

Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

Medical methods and systems are provided for effecting lung volume reduction by selectively ablating segments of lung tissue.

Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input. The system, delivery devices, and methods can damage tissue and manage scarring and stenosis.

The present disclosure is directed to an expandable energy delivery assembly adapted to deliver electrical energy to tissue. The assembly includes an elongate device including an irrigation shaft defining a irrigation lumen fluidly couplable to an irrigation source and a rapid exchange shaft defining a guidewire lumen configured for reception and passage of a guidewire. The assembly also includes an inflatable element that is secured to the elongate device. The inflatable element includes a double helical electrode disposed on the inflatable element that makes between about 0.5 to about 1.5 revolutions around the inflatable element.

An electrophysiology catheter has a micro capacitive tactile sensor provided in the distal section. The distal section may include a tip electrode, a ring electrode and/or a balloon catheter adapted for tissue contact. The capacitive force sensor is configured to exhibit a change in capacitance with tissue contact wherein the force applied with tissue contact is measured and reliably calibrated in assessing and determining the applied force. The capacitive force sensor has a first plate affixed to a tissue contact portion of the catheter, a second plate configured for contact with the tissue, and an elastically compressible dielectric between the first and second plates, wherein the force sensor has a first capacitance when the first and second plates are separated by a first distance, and the force sensor has a second capacitance when the first and second plates are separated by a second different from the first distance.

A catheter includes a body having a proximal region that extends along a longitudinal axis, a distal region predisposed into a loop via shaping wire, and a neck region between the proximal and distal regions. The loop is disposed in a plane generally orthogonal to the longitudinal axis. An activation wire is coupled to the distal region and to an actuator in a manner that allows a user to adjust the radius of the loop. The activation and shaping wires are contained within a tube-shaped constraint, such as a spring coil, within the neck in order to the neck from nodding when the activation wire is activated.

A mapping and ablation catheter is presented. The mapping and ablation catheter comprising an elongated catheter shaft and an ablation portion being arranged at a distal end of the catheter shaft, wherein: the ablation portion comprises a plurality of loop segments; at least one first loop segment of the plurality of loop segments exhibits one or more ablation electrodes, the one or more ablation electrodes being configured for delivering energy to vascular tissue; the loop segments together form a three-dimensional spiral; and respective diameters of the loop segments are such that each loop segment rests on a neighboring loop segment when the three-dimensional spiral is compressed. The plurality of loop segments comprises a stabilizer loop segment, which does not does not exhibit any electrodes, wherein the stabilizer loop segment is the most proximal loop segment of the plurality of loop segments.

The present invention relates to an ablation equipment (100) to treat target regions of tissue (41) in organs (44), comprising an ablation catheter (1) and a single power source (4);

said ablation catheter (1) comprising: a catheter elongated shaft (13) comprising at least an elongated shaft distal portion (17); said catheter elongated shaft (13) comprising a flexible body (207) to navigate through body vessels (208);
said ablation catheter (1) further comprising a shaft ablation assembly (20) disposed at said elongated shaft distal portion (17); said shaft ablation assembly (2) comprising at least a plurality of electrodes (127, 113 or 114) fixedly disposed at said elongated shaft distal portion (17);
all electrodes of said at least a plurality (127, 113 or 114) being electrically powered by said single power source (4) through an electric signal (S) to deliver both non-thermal energy for treating the tissue (41) and thermal energy for ablating the tissue (41);
wherein
said single power source (4), when requested, changes continuously said electric signal (S) in order to power the said least a plurality of electrodes (127, 113 or 114) to deliver from a non-thermal energy to a thermal energy, and vice versa, or to deliver at the same time a combination of thermal energy and non-thermal energy.

Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.