The present invention provides systems and devices for ablation with bendable electrodes, including the system console of ablation energy, pacing and ECG unit as well as ablation catheter. The ablation energy is radio frequency (RF) or voltage pulse. The ablation catheter is connected to the system console of the ablation energy through a converter, and the ablation energy is transmitted to the ablation tissue through electrodes on the ablation catheter, leading to degeneration of tissue cells. The ablation catheter includes an elastically retractable spline basket made up of a plurality of extendable splines, each spline has at least one electrode attached on the surface. The bendable electrodes have good adaptability, and can automatically fit to configuration of different ablation tissue, thus overcoming the nondeformable issue of long traditional ring-shaped electrode, thereby achieving a better ablation effect. The distal end of the spline basket is also coupled with an annular catheter entering the pulmonary vein (PV). Using different configuration of electrodes contacting tissue and variable combination of the electrodes in spline basket and annular catheter for various discharge ablation patterns, local, linear, annular or uniformly distributed large-area irreversible lesion can be formed, thereby achieving the purpose of treating arrhythmia diseases such as atrial flutter, supraventricular tachycardia, and atrial fibrillation (AF).

The invention relates to an ablation catheter for treatment of a patient's tissue, for example for a PVI procedure on a patient's heart, comprising an elongated catheter shaft and an ablation portion being arranged at a distal end of the catheter shaft with a plurality of electrodes accommodated along the ablation portion, wherein the ablation portion comprises at least two loop sections forming a three-dimensional spiral. In order to increase safety of ablation treatment, spare adjacent tissue (e.g. nerves, vessels, esophagus) and shorten ablation time, a pitch, or clearance of two neighboring loop sections is greater than an ionization threshold of the medium around the distal section, for example blood or gases resulted from electrolysis. The invention further relates to an operation method of such ablation catheter.

An electrode assembly includes an electrically-conductive wire configured for insertion into a blood vessel of a subject, an electrode surrounding the wire, and a discontinuous electrically-insulating cover disposed between the wire and the electrode such that the wire lies radially opposite the electrode at a break in the discontinuous electrically-insulating cover. Other embodiments are also described.

A lung denervation method comprises advancing a catheter along the airway; deploying an open loop in contact with the epithelium; simultaneously delivering radio frequency energy from a plurality of discrete spaced-apart locations along the loop to target regions according to a set of ablation parameters sufficient to heat and interrupt nerve functionality; and forming a liquid film between the loop and the epithelium for minimizing collateral damage. The method serves to destroy motor axons of the peripheral bronchial nerve, blocks parasympathetic transmission in the pulmonary and reduces acetylcholine release, reducing airway smooth muscle tension and mucus production. Related systems are described.

A medical system, including a medical device having a plurality of deployable arms, and at least one electrode on at least one of the plurality of arms; and an electric signal generator in communication with the medical device, the electric signal generator programmed to deliver pulsed energy to the medical device sufficient to induce irreversible electroporation ablation.

Catheter apparatuses, systems, and methods for achieving neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a therapeutic assembly that includes an elongated tubular shaft having a pre-formed spiral shape when in a deployed state (e.g., a radially expanded, generally spiral/helical shape) and a thermocouple assembly helically wrapped about the shaft. In one embodiment, the thermocouple assembly comprises first and second wires composed of dissimilar metals with the first wire including a plurality of exposed and insulated regions along the distal portion of the treatment device. The exposed regions of the first wire define a plurality of energy delivery portions positioned to deliver electrical energy (e.g., RF energy, pulsed energy, etc.) to target tissue adjacent a wall of an artery (e.g., a renal artery) to heat or otherwise electrically modulate neural fibers that contribute to physiological function (e.g., renal function).

Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed.

Embodiments disclosed herein are directed to devices, methods, and systems for the treatment of tissue using energy delivery. Specifically, certain embodiments may be used for the treatment of lung tissue, such as lung nodules, using RF ablation, via a catheter provided with a first electrode attached to a distal end of the catheter, wherein the first electrode is hollow, wherein the first electrode comprises a piercing tip configured to pierce through an airway wall and a second electrode received in a movable manner within the first electrode, wherein the second electrode is extendable from the first electrode to form a first extended configuration.

An electrophysiology catheter has a micro capacitive tactile sensor provided in the distal section. The distal section may include a tip electrode, a ring electrode and/or a balloon catheter adapted for tissue contact. The capacitive force sensor is configured to exhibit a change in capacitance with tissue contact wherein the force applied with tissue contact is measured and reliably calibrated in assessing and determining the applied force. The capacitive force sensor has a first plate affixed to a tissue contact portion of the catheter, a second plate configured for contact with the tissue, and an elastically compressible dielectric between the first and second plates, wherein the force sensor has a first capacitance when the first and second plates are separated by a first distance, and the force sensor has a second capacitance when the first and second plates are separated by a second different from the first distance.

The present disclosure provides a RF ablation catheter for treatment of atrial fibrillation of the heart, the RF ablation catheter including: a body part which has one or more ablation electrodes formed on a distal part and which constitutes a catheter body made of a soft material; and a tapered tip which is connected to the body part and becomes thinner toward an end thereof, wherein a guidewire lumen into which a guidewire is inserted is formed to be connected to the tip and the body part.

The present disclosure provides a method for treatment of atrial fibrillation of the heart, the method including: inserting a guidewire from the superior vena cava or inferior vena cava into the vein of Marshall via a coronary sinus; placing a RF ablation catheter, which has an ablation electrode formed on a distal part, in the vein of Marshall according to guidance of the guidewire; and performing RF ablation around the vein of Marshall after connecting the RF ablation catheter to a RF generator.