An electronic forceps system includes a handle including a pair of pivotable arms distally extending from a proximal end of the handle, at least one arm of the pair of arms having an electrically-conductive arm element connectable to a power source, wherein each arm of the pair of arms comprises a respective pair of arm interfaces, and the electrically-conductive arm element extends to at least one interface of the pair of interfaces. Also provided is a pair of tips, at least one tip of the pair of tips having an electrically-conductive tip element, wherein each tip has a tip interface configured to removably connect to a respective arm interface, each tip has a distal working surface, the electrically-conductive tip element is configured to removably and electrically connect to the electrically-conductive arm element, the electrically-conductive tip element is connected to a heater.

Systems, devices, and methods for electroporation ablation therapy are disclosed, with the device including a first jaw including a plurality of first electrodes and a second jaw including a plurality of second electrodes. The first jaw and the second jaw may be substantially rigid, elongate, and collectively define a longitudinal axis. The first jaw and the second jaw may be configured to engage tissue therebetween during use.

High-voltage pulses ablation systems and methods are used to ablate tissue and form lesions. A variety of different electrophysiology devices, such as catheters, surgical probes, and clamps, may be used to position one or more electrodes at a target location. Electrodes can be connected to power supply lines and, in some instances, the power to the electrodes can be controlled on an electrode-by-electrode basis. High-voltage pulse sequences provide a total amount of heating that is typically less than that which is observed with thermally-based radiofrequency energy ablation protocols.