A microneedling system may reciprocate a plurality of microneedles disposed on a handpiece into the skin of a patient. The microneedles and/or electrode plates may deliver RF energy to the patient for inducing collagen coagulation and regeneration. An interrogative modality such as ultrasound may combined into the microneedling handpiece or used as a separate instrument to interrogate the skin and identify or measure the thicknesses of constituent layers. The data obtained from the interrogative modality may be displayed and can be used to automatically adjust operating parameters of the microneedling device, including the penetration depth of the needles, the pulse duration, and/or the power level of the RF energy to optimize the treatment for the specific patient and/or condition being treated. The microneedling system may recall the skin measurements for distinct sectors of the skin which are expected to have different properties.

Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

A method for adaptive control of surgical network control and interaction is disclosed. The surgical network includes a surgical feedback system. The surgical feedback system includes a surgical instrument, a data source, and a surgical hub configured to communicably couple to the data source and the surgical instrument. The surgical hub includes a control circuit. The method includes receiving, by the control circuit, information related to devices communicatively coupled to the surgical network; and adaptively controlling, by the control circuit, the surgical network based on the received information.

A method for ablating tissue in a subject, including providing a probe, having an electrode, that is inserted into a lumen of the subject, so that the electrode is in proximity to the tissue to be ablated. An immobilizing signal is injected into the subject, via the electrode, that immobilizes the subject. When the subject is immobilized, an ablation signal is injected via the electrode into the subject, the ablation signal being configured to ablate the tissue of the subject by irreversible electroporation. The ablation signal has at least one train of first pulses, each of the first pulses in the at least one train having a first pulse absolute amplitude, and the immobilizing signal has one or more trains of second pulses, each of the second pulses in the one or more trains having a second pulse absolute amplitude less than the first pulse absolute amplitude.

A medical system includes a catheter, a light source, a detector, a circulator, and a processor. The catheter includes a distal-end assembly for performing a medical operation on tissue in a cavity of an organ of a patient, the distal-end assembly including an optical fiber configured to guide transmitted light to interact with the tissue of the cavity, and to guide returned light that interacted with the tissue. The light source is configured to produce the transmitted light. The detector is configured to measure the returned light. The circulator is configured to couple the transmitted light from the light source to the optical fiber, and to couple the returned light from the optical fiber to the detector. The processor is configured to identify a contact of the distal-end assembly with the tissue based on the returned light measured by the detector, and to indicate the identified contact to a user.

Cable connection systems allow for an electrosurgical return electrode to be simultaneously connected to multiple ESUs. The cable connection systems can include individual return cables for simultaneous connection to each of the ESUs. The cable connection system can also include a junction that joins, connects, or associates the return cables in a manner that allows for the multiple ESU cables to be electrically connected to the return electrode at a single connection point on the return electrode.

Systems and methods for neuromodulation therapy are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a plurality of reference electrodes at the skin of a human patient and intravascularly positioning a plurality of ablation electrodes within a blood vessel lumen at a treatment site. The method can include obtaining impedance measurements between different combinations of the reference electrodes and the ablation electrodes and, based on the impedance measurements, identifying two or more electrode groups for treatment, where at least two of the electrode groups include a different one of the reference electrodes and a different one of the ablation electrodes.

An electroporation ablation system for treating targeted tissue in a patient. The electroporation ablation system including an ablation catheter and an electroporation generator. The ablation catheter including a handle, a shaft having a distal end, and catheter electrodes situated at the distal end of the shaft and spatially arranged to generate electric fields in the targeted tissue in response to electrical pulses. The electroporation generator operatively coupled to the catheter electrodes and configured to deliver the electrical pulses in an irreversible electroporation pulse sequence that includes a preconditioning pulse sequence and an electroporation pulse sequence to one or more catheter electrodes. Wherein the preconditioning pulse sequence includes preconditioning electrical pulses configured to cause electrolysis near the targeted tissue and tetanizing skeletal muscle stimulation in the patient.

A surgical instrument is configured to reduce conductivity between an RF electrosurgical portion and a cutting portion. This reduces improves the efficiency and consistency of the generated RF field, with higher current densities nearest the target tissue, improving the performance of the RF electrosurgical instrument. The conductivity may be reduced using a layer of insulating material, a projecting insulating portion or a cutting portion constructed from an insulating material. Further, by providing a lubricous insulating layer shedding may be reduced, increasing the usable life of the cutting portion.

An electrosurgical instrument end effector includes an active electrode received by an insulating material, the active electrode including a primary suction aperture which provides access to a primary fluid channel extending from the active electrode, through the insulating material, to a lumen. The lumen is arranged to carry fluid to and from a surgical site when in use. The end effector further includes at least one additional fluid channel providing alternative access to the primary fluid channel from the active electrode, wherein the at least one additional fluid channel bypasses the primary suction aperture.