An automated laser-surgery system for performing a closed-loop surgical procedure is disclosed. The procedure includes forming a post-procedural goal based on a three-dimensional (3D) image of a surgical site, planning a path for a surgical laser signal based on the post-procedural goal, performing a procedural pass by steering the surgical laser signal along the path, measuring the surface of the surgical site after the procedural pass, updating a model based on the measured effect at the surgical site, and evaluating the success of the procedural pass based on the surface measurement and the post-procedural goal. If necessary, a new path is planned based on the post-procedural goal and the surface measurement a new pass based on that path is performed, and the surface is again measured to evaluate the success of the new pass. These operations are repeated as a closed-loop sequence as many times as necessary to achieve success.

An ophthalmic surgical laser system and method for forming a lenticule in a subject's eye using “fast-scan-slow-sweep” scanning scheme. A high frequency scanner forms a fast scan line, which is placed by the XY and Z scanners at a location tangential to a parallel of latitude of the surface of the lenticule. The XY and Z scanners then move the scan line in a slow sweep trajectory along a meridian of longitude of the surface of the lenticule in one sweep. Multiple sweeps are performed along different meridians to form the entire lenticule surface, and a prism is used to change the orientation of the scan line of the high frequency scanner between successive sweeps. In each sweep, the sweeping speed along the meridian is variable, being the slowest at the edge of the lenticule and the fastest near the apex.

A co/counter propagating acousto-optic modulator is provided that creates a low-intensity focused ultrasound (FUS) wave on a laser beam in a medium such as water without any auxiliary mediators or special software/hardware. The main optical effect of the FUS is the controllable focusing of the laser beam through modification of the refractive index of the medium in a time-stable and dynamic fashion. The laser beam and the FUS wave are coaxially mixed and propagated through each other. The FUS pressure field highly amplifies the power density, highly amplifies the intensity, sharpens the diameter, and reduces the full width at half maximum (FWHM) of the laser beam. The FUS pressure field keeps the laser beam's lensing power positive, with small fluctuations, as long as the ultrasound wave is coaxially propagated with the laser beam.

Systems, devices, and methods for treating a skin of a patient with therapeutic laser light via imaging a first skin area of the patient to obtain at least a first image, processing the at least a first image of the first skin area with at least one processor to identify within the first skin area at least one or more target skin areas and a non-target skin area, generating a treatment map of the first skin area based on the identified one or more target skin areas and the non-target skin area, and treating at least a portion of the one or more target skin areas with therapeutic laser light based on the generated treatment map.

A system for direct imaging and diagnosing of abnormal cells in a target tissue includes a disposable optical speculum and an image acquisition system having the speculum assembled on and mechanically secured thereto. The image acquisition system is arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets. An image analysis and control unit in communication with the image acquisition system analyzes the data sets and applies algorithms to the data sets for diagnosing abnormal cells.

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

The present invention concerns a cutting apparatus including a femtosecond laser (1), a shaping system (2) downstream from the femtosecond laser (1), for forming a phase-modulated laser beam, an optical scanner (4) downstream from the shaping system (2), and optical focusing system (5) downstream from the optical scanner (4), a control unit (6) for controlling the shaping system (2), the optical scanner (4) and the optical focusing system (5), characterized in that the apparatus further comprises an optical coupler (3) between the femtosecond laser (1) and the shaping system (2), the optical coupler (3) including a photonic crystal optical fiber for filtering the phase-modulated laser beam (21) coming from the shaping system (2).

The present invention relates to a device for controlling the movement of an ocular therapy apparatus of the type comprising an articulated support arm (2), of which the free end is intended to be placed opposite an ocular tissue, an acquisition system (4) mounted on the arm (2) for acquisition of a measurement pair comprising an image of the ocular tissue, and a signal representative of a vertical distance along the axis Z between the end of the arm and the ocular tissue, characterized in that the control device (5) comprises means for actuating the acquisition system (4), means for processing each measurement pair acquired, and servo means for moving the free end of the arm (2) between an initial position and a desired final position.

The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage or cornea, without using a photosensitizer (e.g., riboflavin), by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of tissue. In an embodiment, the femtosecond laser operates in the infrared frequency range.

An aesthetic treatment device uses multiple light sources, lasers or LEDs focused on the treatment area from different directions. The multiple light sources for treatment purposes could have the same wavelength or different wavelengths each optimized for a different application. Target selection is performed by a dual wavelength smart illumination system combined with an imaging system, a smart processor for target recognition and a scanning system that directs the focused light from laser sources to an automatically selected treatment area. A motorized optical system performs a dual role of: focusing the laser sources and also steering the focused light to specific locations as designated by the imaging and processing systems.