A system for direct imaging and diagnosing of abnormal cells in a target tissue includes a disposable optical speculum and an image acquisition system having the speculum assembled on and mechanically secured thereto. The image acquisition system is arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets. An image analysis and control unit in communication with the image acquisition system analyzes the data sets and applies algorithms to the data sets for diagnosing abnormal cells.

A method and system of ablating melanin are provided. Stepwise multi-photon fluorescence is induced in melanin within a region of tissue. The fluorescence is detected, and at least a portion of the melanin from which the fluorescence is detected is ablated. The system and method can use a continuous wave laser in the near infrared range for the inducement and ablation of melanin, providing high resolution at low cost.

A microchip laser and a handpiece including the microchip laser. The microchip laser includes a laser medium with input and output facets. The input facet is coated with a highly reflective dielectric coating at microchip laser wavelength and highly transmissive at pump wavelength. The output facet is coated with a partially reflective at microchip laser wavelength dielectric coating. A saturable absorber attached by intermolecular forces to output facet of microchip laser. A handpiece for skin treatment includes the microchip laser.

An ophthalmic surgery laser system and method of laser delivery for an ophthalmic surgery laser system are disclosed herein. Embodiments of the system and method are directed to an ophthalmic surgery laser system including a laser engine, a laser guide, and a laser shaper. Embodiments of the system and method are directed to a laser delivery system for an ophthalmic surgery laser system. Embodiments of the system and method are directed to an ophthalmic surgery laser system including additional functionality such as laser scanning confocal microscopy, 3D laser scanning, and laser beam diagnostics. Embodiments further include the use of a lower power illumination source.

An ophthalmic surgery laser system and method of laser delivery for an ophthalmic surgery laser system are disclosed herein. Embodiments of the system and method are directed to an ophthalmic surgery laser system including a laser engine, a laser guide, and a laser shaper. Embodiments of the system and method are directed to a laser delivery system for an ophthalmic surgery laser system. Embodiments of the system and method are directed to an ophthalmic surgery laser system including additional functionality such as laser scanning confocal microscopy, 3D laser scanning, and laser beam diagnostics. Embodiments further include the use of a lower power illumination source.

A laser treatment apparatus includes an irradiation system, a wavefront changing unit, and a controller. The irradiation system is configured to output laser light for treatment from a light source. The wavefront changing unit is configured to change a wave front of the laser light for treatment output by the irradiation system to guide the laser light for treatment whose wave front is changed to a patient's eye. The controller is configured to control the wavefront changing unit.

A microchip laser and a handpiece including the microchip laser. The microchip laser includes a laser medium with input and output facets. The input facet is coated with a highly reflective dielectric coating at microchip laser wavelength and highly transmissive at pump wavelength. The output facet is coated with a partially reflective at microchip laser wavelength dielectric coating. A saturable absorber attached by intermolecular forces to output facet of microchip laser. A handpiece for skin treatment includes the microchip laser.

A cooling element includes a frame including one or more datums. The cooling element also includes a first window including a first proximal surface and a first distal surface. The first window is sealed to the frame. The cooling element further includes a second window sealed to the frame. The second window includes a second proximal surface and a second distal surface. The second window is configured to contact a target tissue or a tissue adjacent to the target tissue via the second distal surface. The cooing element also includes a coolant chamber located between the first distal surface of the first window and the second proximal surface of the second window and configured to receive a coolant. The first window, the second window and the coolant chamber are configured to receive and electromagnetic radiation (EMR), and transmit a portion of the received EMR to the target tissue.

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

A digital control laser automatic tooth preparation method and device and a tooth positioner are provided. The device includes an intra-oral three-dimensional scanner, a dental laser, an oral working end of a digital control laser tooth preparation control system, an oral and maxillofacial cone beam CT scanner, a computer, a tooth positioner, a negative-pressure suction device and a real-time monitoring device. The computer is connected respectively with the intra-oral three-dimensional scanner, the dental laser, the oral working end of the digital control laser tooth preparation control system, the oral and maxillofacial cone beam CT scanner, the negative-pressure suction device, and the real-time monitoring device. The dental laser is connected with the oral working end of the digital control laser tooth preparation control system through a light guiding arm (1). The oral working end of the digital control laser tooth preparation control system is connected with the tooth positioner and the real-time monitoring device. The negative-pressure suction device is connected with the tooth positioner. The digital control laser automatic tooth preparation method and device according to embodiments of the present invention can replace part of manual operations of a doctor, uses a laser to replace a conventional mechanical grinding instrument, and can effectively improve the standard level and efficiency of clinical oral tooth preparation.