A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

In one aspect, methods of treating a wound are described herein. A method described herein, in some embodiments, comprises treating a wound, such as a chronic wound, by performing a full field laser ablation in a wound bed of the wound and subsequently performing a fractional laser ablation in the wound bed. Additionally, in some cases, the fractional laser ablation step is carried out at substantially the same time as, or immediately following, the full field laser ablation step. In addition, in some instances, a method described herein further comprises performing debridement in the wound bed prior to performing the full field laser ablation in the wound bed.

A method and system of ablating melanin are provided. Stepwise multi-photon fluorescence is induced in melanin within a region of tissue. The fluorescence is detected, and at least a portion of the melanin from which the fluorescence is detected is ablated. The system and method can use a continuous wave laser in the near infrared range for the inducement and ablation of melanin, providing high resolution at low cost.

A laser device can provide a prompt, precise, and stable laser therapy in that it can: (i) minimize post-treatment adverse reactions, such as hyperpigmentation, erythema, etc., by using a cooling device to induce vasoconstriction and perform laser treatment of the skin lesion areas under vasoconstriction to minimize occurrence of inflammation from irradiation of laser on normal tissues and capillary loops, when using laser to treat pigmentary disorders of the skin; (ii) minimize adverse reactions associated with laser treatments by promptly and precisely completing laser treatment specifically targeting the lesion area by capturing and analyzing the images of the skin lesion area under the area-specific vasoconstriction performed by using the cooling device; (iii) prevent or significantly delay occurrence of fogging onto the light transmitting member by using a cooling method; (iv) ensure the complete contact between the skin contact surface of the light transmitting member and the skin lesion by using a sensor; (v) target the laser beam using a scanner; and (vi) ensure the complete coverage of laser irradiation on the skin lesion by irradiating the laser beam in an overlapping manner.

A method of data acquisition and image generation over a wide and dynamic time interval between surface scans using modified electrical waves is disclosed. It is also disclosed that generating altered electrical waveforms that drive a scanner using conventional waves such as sinusoidal or triangle or sawtooth can enhance the method. Systems for A-scan, B-scan, and C-scan imaging pp include surface scan setups using a one-dimensional and a two-dimensional scanner, respectively. Three different arrangements of conventional waves enable modified waveforms that drive scanners to produce a wide and dynamic interscans time interval on both the fast and slow scan axes. (i) At a constant peak-to-peak voltage, the instantaneous voltage of the electrical sinusoidal wave shifts in time with the amplitude of the electrical signal in the ramp waveform within a range. (ii) The frequency of a waveform continuously increases (up-chirp) as a function of time in the form of a positive ramp sawtooth or continuously decreases as a function of time in the form of a negative ramp sawtooth. (iii) The frequency of a waveform is modulated as a function of time in a 90-degree phase retarded sinusoidal form within a deviation range of the +/ peak frequency.

A catheter system (100) for treating a treatment site (106) includes a first light source (124), a plurality of light guides (122A), a multiplexer (128), a multiplexer alignment system (142), and a first beamsplitter (268). The first light source (124) generates a source beam (124A). The multiplexer (128) receives the source beam (124A), and alternatively directs the source beam (124A) to each of the plurality of light guides (122A). The multiplexer alignment system (142) is operatively coupled to the multiplexer (128). The multiplexer alignment system (142) includes a second light source (270) that generates a probe source beam (270A) that is directed to scan across a guide proximal end (122P) of each of the plurality of light guides (122A) so that a time is determined to generate the source beam (124A) so that the source beam (124A) is optically coupled to the guide proximal end (122P) of each of the plurality of light guides (122A). The first beamsplitter (268) receives the source beam (124A) and the probe source beam (270A), and alternately directs the probe source beam (270A) and the source beam (124A) toward the guide proximal end (122P) of each of the plurality of light guides (122A).

A system for working biological tissue, the system comprising: a tool comprising a laser operable to perform at least one action of work; positioning means for positioning the tool relative to the biological tissue to perform the at least one action of work; a controller; storage storing electronic program instructions for controlling the controller; and an input means; wherein the controller is operable, under control of the electronic program instructions, to: receive input via the input means; process the input and, on the basis of the processing, control the positioning means and the tool to work the biological tissue.

Apparatus and techniques described herein can include delivery of a surgical laser beam for tissue excision or to facilitate hemostasis. The surgical laser beam can be generated, for example, using an ultrafast laser source. Such an approach can provide non-invasive treatment in relation to, for example, aerodigestive anatomy, such as for treatment of laryngeal, oropharyngeal, bronchial, and oral cavity tissues. Other generally available laser sources and their associated treatments may present various drawbacks making them less suitable for treatment for laryngeal, pharyngeal or bronchial pathologies, and use of the apparatus and techniques described herein can address such drawbacks.

A hair removal device performs hair removal treatment with light emitted from a light source, and includes: a light source unit including the light source; an imaging unit capable of taking an image of a treatment target area of the skin; a pore specifying unit that specifies a pore present within the treatment target area on the basis of image data of the treatment target area whose image has been taken by the imaging unit; a shift amount detecting unit that detects a shift amount of a pore position associated with a position shift of the hair removal device from the pore position of the time the image of the treatment target area has been taken; and the irradiation position correcting unit that corrects an irradiation position of light with respect to the pore on the basis of the shift amount detected by the shift amount detecting unit.