The present disclosure relates to methods and systems for removing a vascular obstruction in a subject using a combination of thrombolytic and laser ablation therapy. Treatment methods include positioning a catheter adjacent to an obstruction within a vessel of a subject. A portion of the obstruction may be ablated by delivering laser energy through the optical fibers to the distal end of the catheter, where the optical fibers are exposed, and circulating a fluid containing one or more thrombolytic agents to a remaining portion of the obstruction for a predetermined amount time. Fluid containing one or more thrombolytic agents capable of dissolving a remaining portion of the obstruction may be circulated through the fluid delivery lumen and removed through the fluid removal lumen.

An optical fibre for an ultrafast laser endoscope including at least the following structures: a hollow core, the periphery of which has an order of symmetry of at least six when considering axes of symmetry passing through the centre of the core and through the centre of convex shapes, seen from the centre of the core, the convex shapes at least partly making up the periphery of the core; an intermediate layer of cellular structure surrounding the core; a lightconducting peripheral structure surrounding the intermediate layer of cellular structure; and an outer sheath surrounding the light-conducting peripheral structure. A particular advantage of the optical fibre is that it optimizes the emission of a high-power flux associated with fluorescence collection.

A medical instrument includes a housing and a shaft coupled to the housing. The shaft has a proximal end and a distal end. An end effector assembly is disposed at the distal end of the shaft. The end effector assembly includes first and second jaw members. At least one of the first and second jaw members is movable from a first position wherein the first and second jaw members are disposed in spaced relation relative to one another to at least a second position closer to one another wherein the first and second jaw members cooperate to grasp tissue therebetween. The medical instrument also includes one or more light-emitting elements and one or more light-detecting elements configured to generate one or more signals indicative of tissue reflectance. The one or more light-emitting elements are adapted to deliver light energy to tissue grasped between the first and second jaw members.

A curved laser probe with single-use optic fiber may include a reusable handle, an optic fiber fixture, and a single-use optic fiber. The single-use optic fiber may include an optic fiber having an optic fiber distal end and an optic fiber proximal end. The optic fiber may be disposed in a first transitory connector having a first transitory connector distal end and a first transitory connector proximal end wherein the optic fiber distal end extends a fixed distance from the transitory connector distal end. The optic fiber may be disposed in a second transitory connector having a second transitory connector distal end and a second transitory connector proximal end wherein the optic fiber proximal end extends a fixed distance from the second transitory connector distal end. The first transitory connector may be inserted in the reusable handle and the second transitory connector may be inserted in the optic fiber fixture.

Catheter systems of the invention are directed to the removal of occlusions, such as thrombi and plaque, within blood vessels. In certain aspects, catheter systems of the invention include an elongate body defining a first lumen and comprising a distal portion, an inner member configured for insertion into the first lumen, the inner member comprising an energy source configured to deliver therapeutic energy to a treatment site; and a dissolution element coupled to the distal portion of the elongate body. The dissolution element may include a heating element, steam, and a balloon.

A fiber optic probe includes a first diffuse reflectance spectroscopy fiber, a second diffuse reflectance spectroscopy fiber, and a temperature sensor at a distal end of a temperature sensor fiber. Other embodiments further include a treatment fiber for delivering a high optical power density of light to a tumor and a dosimetry fiber for monitoring the light flux of the treatment fiber. Other embodiments utilize an image-guidance step in a method of using the fiber optic probe.

Aspects of this disclosure pertain to a device with an elongated body having a distal end. The distal end may comprise a port that permits discharge of a laser energy towards a tissue from an optical fiber located in the distal end. An exterior surface of the distal end may include a cauterization portion that permits discharge of a cauterization energy towards the tissue. In some aspects, the device includes an insulative portion that attaches the distal end to the elongated body and limits energy transfer therebetween. Related systems and methods are also disclosed.

A system to treat a patient comprises a user interface that allows a physician to view an image of tissue to be treated in order to develop a treatment plan to resect tissue with a predefined removal profile. The image may comprise a plurality of images, and the planned treatment is shown on the images. The treatment probe may comprise an anchor, and the image shown on the screen may have a reference image marker shown on the screen corresponding to the anchor. The planned tissue removal profile can be displayed and scaled to the image of the target tissue of an organ such as the prostate, and the physician can adjust the treatment profile based on the scaled images to provide a treatment profile in three dimensions. The images shown on the display may comprise segmented images of the patient with treatment plan overlaid on the images.

A catheter system (100) includes an energy source (124), a catheter shaft (110), a balloon (104), a plurality of energy guides (122A), a plurality of emitters (135), and a system controller (126). The energy source (124) generates energy. The balloon (104) is coupled to the catheter shaft (110). The balloon (104) includes a balloon wall (130) that defines a balloon interior (146) that retains a catheter fluid (132). The energy guides (122A) selectively receive energy from the energy source (124). The emitters (135) are positioned within the balloon interior (146). Each emitter (135) includes a guide distal end (122D) of one of the energy guides (122A) and a corresponding plasma generator (133) that is spaced apart from the guide distal end (122D). The energy received by each of the energy guides (122A) is emitted from the guide distal end (122D) and impinges on the corresponding plasma generator (133) so that plasma is generated in the catheter fluid (132) within the balloon interior (146). The system controller (126) controls the energy source (124) so that energy from the energy source (124) is alternatively directed to each of the energy guides (122A) in a first pattern of firing and a second pattern of firing that is different than the first pattern of firing.

A catheter system (100) for placement within a blood vessel (108) having a vessel wall (108A) can be used for treating a treatment site (106) within or adjacent to the vessel wall (108A). The catheter system (100) includes an energy source (124), a plurality of energy guides (122A), and a plurality of emitters (135). The energy source (124) generates energy. Each of the energy guides (122A) is configured to selectively receive the energy from the energy source (124). Each of the energy guides (122A) includes a corresponding guide distal end (122D). The energy that is received by each of the energy guides (122A) is emitted from the corresponding guide distal end (122D). Each of the emitters (135) is positionable near the treatment site (106). Each of the emitters (135) includes the corresponding guide distal end (122D) of one of the energy guides (122A). At least one of the emitters (135) includes a radiopaque material.