A laser lithotripsy system to deliver laser energy from one or more laser sources to a stone (e.g., mobile calculus), the system including a capture portion, a first laser node and a second laser node. The capture portion configured to be movable from a stored state to a deployed state. In the deployed state, the capture portion is configured to at least partially surround the stone. The first laser node and the second laser node are coupled to the capture portion and are configured to deliver the laser energy to the stone, and the first laser node is spaced apart from the second laser node.

The present disclosure relates to a multi-core optical fiber cable (MCF). In some embodiments, an MCF comprises a plurality of cores surrounded by a cladding and a coating surrounding the cladding, wherein a refractive index of one or more of the plurality of cores is greater than a refractive index of the cladding. The MCF further comprises a probe comprising a probe tip coupled with a distal end of the MCF and a lens located at a distal end of the probe tip. In some embodiments, the lens is configured to translate laser light from the distal end of the MCF to create a multi-spot pattern of laser beams on a target surface and a distal end of the MCF terminates at an interface with the lens.

A catheter system (100) for placement within a treatment site (106) at a vessel wall (208A) or a heart valve includes an energy source (124), a balloon (104), an energy guide (122A), and a tissue identification system (142). The energy source (124) generates energy. The balloon (104) is positionable substantially adjacent to the treatment site (106). The balloon (104) has a balloon wall (130) that defines a balloon interior (146). The balloon (104) is configured to retain a balloon fluid (132) within the balloon interior (146). The energy guide (122A) is configured to receive energy from the energy source (124) and guide the energy into the balloon interior (146) so that plasma is formed in the balloon fluid (132) within the balloon interior (146). The tissue identification system (142) is configured to spectroscopically analyze tissue within the treatment site (106). A method for treating a treatment site (106) within or adjacent to a vessel wall (208A) or a heart valve can utilize any of the catheter systems (100) described herein.

A catheter system (100) for treating a treatment site (106) within or adjacent to the vessel wall of a blood vessel (108), or the heart valve, includes an energy source (124), a balloon (104), an energy guide (122A), and a balloon integrity protection system (142). The energy source (124) generates energy. The balloon (104) is positionable substantially adjacent to the treatment site (106). The balloon (104) has a balloon wall (130) that defines a balloon interior (146). The balloon (104) is configured to retain a balloon fluid (132) within the balloon interior (146). The energy guide (122A) is configured to receive energy from the energy source (124) and guide the energy into the balloon interior (146) so that plasma is formed in the balloon fluid (132) within the balloon interior (146). The balloon integrity protection system (142) is operatively coupled to the balloon (104). The balloon integrity protection system (142) is configured to inhibit rupture of the balloon (104) due to the plasma formed in the balloon fluid (132) within the balloon interior (146) during use of the catheter system (100).

A mass spectrometry imaging system includes an ionization source located at a first location configured to produce ions from a surface of a sample at the first location; a mass spectrometer located at a second location configured to perform mass spectrometry analysis by analyzing the produced ions based on mass to charge ratio of the ions; and an ion transfer device configured to transfer the ions from the first location to the second location such that the ion transfer device includes a plurality of electrodes, the plurality of electrodes configured to be flexible or flexibly connected to each other, and the ion transfer device is configured to be flexible or re-configurable while transferring the ions.

Certain aspects of the present disclosure provide a probe comprising a tube, wherein one or more optical fibers extend at least partially through the tube for transmitting at least one of a laser light and an illumination light from a light source to a target location. A distal end of the tube comprises a flat-walled morphology, and a protective window with a round edge is press-fit to the distal end. The flat-walled morphology of the distal end of the tube has a reduced diametric interference sensitivity, thus allowing a wider range of tolerances between the window and the tube walls for effective press-fitting.

A catheter system (100) for treating one or more treatment sites (106) within or adjacent to the heart valve (108) includes an energy source (124), a plurality of energy guides (122A), and a balloon assembly (104). The energy source (124) generates energy. The plurality of energy guides (122A) are configured to receive energy from the energy source (124). The balloon assembly (104) includes a plurality of balloons (104A) that are each positionable substantially adjacent to one or more treatment site(s) (106). Each of the plurality of balloons (104A) has a balloon wall (130) that defines a balloon interior (146). Each of the plurality of balloons (104A) is configured to retain a balloon fluid (132) within the balloon interior (146). A portion of at least one of the plurality of energy guides (122A) that receive the energy from the energy source (124) is positioned within the balloon interior (146) of each of the plurality of balloons (104A) so that plasma is formed in the balloon fluid (132) within the balloon interior (146).

Various examples disclosed relate to temperature monitoring of medical probes. The present disclosure includes a medical device including a medical probe and one or more luminescent marks. The medical probe can include a distal portion configured for at least partial insertion into a patient. The one or more luminescent marks can be located on the distal portion of the probe and have a luminescent characteristic correlative to temperature, when illuminated. The luminescent characteristic can provide an indication of the temperature at an internal site of the patient.

Certain aspects of the present disclosure provide a thermally robust laser probe assembly comprising a cannula, wherein one or more optical fibers extend at least partially through the cannula for transmitting laser light from a laser source to a target location. The probe assembly further comprises a lens housed in the cannula and a protective component press-fitted to the distal end of the cannula, wherein the lens is positioned between the one or more optical fibers and the protective component.

A laser atherectomy device includes a light delivery catheter equipped with sensors for monitoring physical characteristics at a laser application site. An integrated control unit utilizing data from said sensors is provided to optimally adjust laser energy parameters and to provide for safe and efficacious ablation of the blood vessel occlusion.