Systems and method relate to administering phototherapy. A device includes a hollow structure having at least a first open end. The hollow structure includes a rotatable member, one or more coherent light generators, and, for each coherent light generator, one or more lenses or mirrors optically connected to the coherent light generator and configured to alter at least one aspect of a beam of coherent light. The device further includes a processing circuit including a processor and a memory storing instructions. The instructions, when executed by the processor, cause the processor to accept an input from an operator and generate one or more beams of coherent light according to a plurality of settings configured to produce a therapeutic effect at a targeted treatment site. Additionally, the rotatable member is configured to be rotated to direct the one or more beams of coherent light to the targeted treatment site.

The present disclosure is related to field of Fiber Feedback (FFB) technology, and provides a method and system for estimating the distance between a fiber end and a target. The method includes illuminating, by a Light Emitting, Transmitting and Detecting (LETD) system, the target with laser light of different wavelengths having low and high water absorption coefficients, using different laser light sources, as well as receiving a returned signal corresponding to the incident laser light of different wavelengths, and detecting the returned signal to measure intensity values of the returned signal of a specific wavelength. Using the measured intensity values, a processing unit may estimate distance between the fiber end and the target. The present disclosure enables accurate estimation of distance between a fiber end and the target. The present disclosure also provides a robust distance estimation technique which is compatible with different types of targets.

The present disclosure relates generally to dual-function medical devices with diagnostic and therapeutic capabilities, such as real-time visualization and ablation. Many embodiments may include an ergonomic handle and dual-lumen catheter configured for dual-function diagnostic and therapeutic use during a medical procedure, such as a duodenoscope. The medical device may be delivered within an endoscope working channel to provide real-time visualization (e.g., radial ultrasound imaging) and treatment (e.g., soft tissue ablation) of cancerous tissue. For instance, a first lumen may include a high-frequency linear or radial ultrasound and the second lumen may include a surgical instrument, such as an ablation tool. Some embodiments may include a controller with a feedback loop configured to adjust the therapeutic tool based on data from the diagnostic tool. For instance, the power of an ablation tool may be adjusted by the controller based on data generated by an imaging device.

A nephroscope can include a body that is at least partially insertable into a kidney of a patient. An articulation controller on a grippable proximal portion of the body can adjust a position of a flexible distal portion of the body to locate a kidney stone when the body is inserted into the kidney of the patient. The articulation controller can optionally releasably lock the articulation of the flexible distal portion, to fixedly position the flexible distal portion at a specified location proximate the kidney stone. The distal end of the body can include an illuminator to illuminate the kidney stone, a camera to provide a video image of the illuminated kidney stone, an optical fiber to deliver laser light that ablates the kidney stone, and an irrigation lumen and a suction lumen to flush the kidney stone and remove kidney stone fragments.

Dermatological systems and methods for providing a therapeutic laser treatment wherein the duration of a therapeutic laser pulse is based on one or more determinations of a surface temperature of the skin during the delivery of the pulse. Initiation of the therapeutic laser pulse may be based on sensed skin temperature during a cooling of the skin prior to initiation of the pulse.

Dermatological systems and methods for providing a therapeutic laser treatment using a handpiece delivering one or more therapeutic laser pulses to a target skin area along a first optical path, and sensing the temperature of the target skin area based on infrared energy radiating from the target skin area along a second optical path generally counterdirectional to the first office action, and sharing a common optical axis with the first optical path for at least a portion of the first and second optical paths. The handpiece may also provide contact cooling for a first skin area comprising the target skin area.

Exemplary embodiments of system, methods and computer-accessible medium can be provided for performing feedback-controlled electromagnetic radiation (EMR)-based treatment. Some exemplary embodiments include an image acquisition system configured to detect information regarding at least one portion of a tissue, and an EMR source configured to generate an EMR beam. A controller can be provided that can be configured to (i) recognize one or more targets within the portion(s) of the tissue based upon the feedback data, (ii) locate one or more coordinates within the portion(s) associated with the target(s), and (iii) control the optical arrangement to direct the EMR beam to impact the coordinate(s).

A laser device (100) has an ablation laser source (401) adapted to provide an ablating laser beam (402; 402i) for ablating a target tissue (120). It further comprises a plume analyzing arrangement (250) adapted to identify and/or quantify substances in the debris of the plume (110) generated by the ablating laser beam (402) ablating the target tissue (120) particularly substances being biomarkers of the ablated target tissue (120).

Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.