The present invention is directed to systems and methods for thermal therapy, especially to detection-guided, -controlled, and temperature-modulated interstitial thermal therapy. Thermal therapy may be used to treat the tissues of a patient. In the case of interstitial thermal therapy, energy is applied to generate heating of the tissue to affect treatment, such as, for example, thermally inducing tissue damage (e.g. thermally-induced tissue necrosis), which may be useful in treating tumors and/or other diseased tissues. Since targets for thermal therapy are internal to the patient, the use of detection guidance may be useful in locating and monitoring treatment of a target tissue.

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

The present invention relates to a method for determining a state of tissue sealing during a tissue sealing process. According to the disclosed method, an optical probe beam is used to irradiate a tissue region. A signal indicative of optical scattering in the tissue region is generated from a portion of the optical probe beam that has passed through or been returned by the tissue region. The onset of tissue sealing is indicated by the successive occurrence in time of a turning point and a point of inflection in the optical scattering signal. An energy-based tissue sealing or tissue-cutting device for use in accordance with the method is also disclosed.

A method for treating a treatment site (106) within or adjacent to a vessel wall (108A) or a heart valve using a catheter system (100) includes the steps of generating light energy (224A, 224B, 324A, 324B, 424B) using a light source (124); directing the light energy (224A, 224B, 324A, 324B, 424B) toward at least one of a first guide proximal end (122P) of a first light guide (122A) and a second guide proximal end (122P) of a second light guide (122A); determining an alignment of the light energy (224A, 224B, 324A, 324B, 424B) relative to the at least one of the guide proximal ends (122P) of the light guides (122A) with an optical alignment system (257); and adjusting a positioning of the light energy (224A, 224B, 324A, 324B, 424B) relative to the at least one of the guide proximal ends (122P) of the light guides (122A) with the optical alignment system (257) based at least partially on the alignment of the light energy (224A, 224B, 324A, 324B, 424B).

Articles of manufacture, including terminations of or attachments to optical fibers are configured to substantially prevent axial emission and redirect radially most if not all light emanating from optical fibers. In that, a termination may include a fiber cap of a unitary construction of a tube and an optical element disposed to face a sealed end of the tube and dividing a hollow of the tube and having a conical surface, or an optical element dividing the hollow and complemented by a cone. An example of termination includes an optical fiber element having an up-tapered end with a maximum taper-diameter exceeding the core-diameter and ending at a conical element with an apex angle from about 700 to about 100. Articles of manufacture additionally including mounting contraptions cooperating such terminations with cannulae to form an attachment to a laser system. Methods for transmitting light through such articles of manufacture.

Embodiments of the invention include a compact, lightweight, hand-held laser treatment device that combines the emissions of two separate laser energy sources into a common optical pathway for improved therapeutic effect. In some embodiments, the device includes a housing having separate first and second laser sources disposed within the interior thereof. In some embodiments, the laser energy emissions from the two internal laser sources can be individually or concurrently transmitted to a delivery tip of the device via a laser transmission path also defined within the interior of the housing. In some embodiments, the structural and functional features of the first and second laser sources, in concert with the unique architecture of the laser transmission path, can be configured to provide efficacy and efficiency in the operation of the device within the spatial constraints of the lightweight, hand-held housing thereof.

A system includes a laser source coupled to an optical waveguide which has a laser output portion, and a vaginal housing transparent to laser energy which is emitted by the laser source and which exits the laser output portion, wherein the optical waveguide is movable along a path inside the vaginal housing.

Disclosed is an optical fiber probe for an optical treatment including a core, to which incident light is guided, a cladding disposed to surround the core, a side surface divergence part connected to the core and configured to diverge the incident light guided to the core to a side surface of a cylindrical column, a diffusion layer disposed to surround the side surface divergence part, a distal end divergence part connected to the side surface divergence part, having a cylindrical shape, and configured to diverge the incident light guided to the side surface divergence part to the outside, and a coating layer disposed to surround the cladding and the diffusion layer and configured to seal the cladding and the diffusion layer, wherein the refractive index of the cladding is lower than the refractive index of the core, the refractive index of the diffusion layer is higher than the refractive index of the core, and the refractive index of the coating layer is higher than the refractive indices of the cladding and the diffusion layer.

An apparatus for obtaining an anti-tumour immunologic response by thermotherapy of a treatment lesion covering at least a portion of a tumour is disclosed. The apparatus comprises a heating probe comprising an optical fiber and a cooling catheter. The optical fiber is inserted in the cooling catheter. Further the heating probe has a light emitting area, and the heating probe is interstitially insertable into the tumour of the treatment lesion. The heat probe is internally cooled by a fluid circulating in said catheter. The apparatus further comprises a first thermal sensor member having at least one sensor area. The first thermal sensor member is positionable at a distance from said boundary. The apparatus also comprises a control unit for controlling a power output of said light source based on a measured first temperature.

A photoacoustic catheter adapted for placement within a blood vessel having a vessel wall includes an elongate shaft, a balloon and a photoacoustic transducer. The elongate shaft can extend from a proximal region to a distal region. The elongate shaft can include a light guide that is configured to be placed in optical communication with a light source. The balloon is coupled to the elongate shaft, and can be configured to expand from a collapsed configuration suitable for advancing the photoacoustic catheter through a patient's vasculature to a first expanded configuration suitable for anchoring the photoacoustic catheter in position relative to a treatment site. The photoacoustic transducer can be disposed on a surface of the balloon and in optical communication with the light guide. The photoacoustic transducer can include a light-absorbing material and a thermal expansion material.