The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

This disclosure provides a photodynamic therapy diagnostic device capable of optical fiber puncture. This device comprises an optical fiber, a laser, a spectrocoupler and a fluorescence analyzer; in which the optical fiber comprises a body portion and a puncture needle head, one end of the body portion is connected with the puncture needle head, and the other end is connected with the spectrocoupler; in which the spectrocoupler is connected with the laser and the fluorescence analyzer to enable a laser emitted by the laser to enter the optical fiber via the spectrocoupler, and a fluorescence produced by the photosensitizer after absorbing the laser to enter fluorescence analyzer via the optical fiber and the spectrocoupler. This therapy diagnostic device, the laser emits a laser with a wavelength that can be absorbed by the photosensitive drug; the laser can pass through the spectrocoupler and then pass through the optical fiber needle tubing, so as to reach the tumor site in the body. The red light is absorbed by the photosensitive drug in the tumor to produce singlet oxygen to kill the tumor cells. The photosensitive drug after being excited produces fluorescence which is collected and transmitted by the optical fiber. Then, the fluorescence enters the fluorescence analyzer via the spectrocoupler. Thereby, the fluorescence quantum yield and the therapeutic effect can be obtained by analyzing the related results, achieving the effect of simultaneous treatment and diagnosis.

The device comprises: an outer tubular structure (21) having a closed terminal end; an inner tubular structure (23), positioned in the outer tubular structure, having a terminal end and defining an inner volume, configured to receive a light guide. A first coolant circulation gap (25) is formed between the outer tubular structure and the inner tubular structure. Between the outer tubular structure (21) and the inner tubular structure (23) a first spacer (33) is located, which develops helically around the longitudinal axis (A-A) of the outer tubular structure (21).

The device comprises: an outer tubular structure (21) having a closed terminal end; an inner tubular structure (23), positioned in the outer tubular structure, and having a side wall with a terminal end and defining an inner volume, configured to receive a light guide (27); in which between the outer tubular structure (21) and the inner tubular structure (23) a first gap (25) for circulation of a coolant is formed; At least a portion of the external tubular structure (21) or the internal tubular structure (23) is diffusing to an electromagnetic radiation propagating in the light guide (27).

The device comprises an outer tubular structure (21) having a closed terminal end, and an inner tubular structure (23) positioned in the outer tubular structure (21) and having a side wall with a terminal end and defining an inner volume. A first gap for circulation of a coolant is formed between the outer tubular structure and the inner tubular structure. A light guide (27) is housed in the inner volume of the inner tubular structure (23). The light guide comprises an optical fiber (28) and a diffuser (30) optically coupled to a distal end of the optical fiber. The diffuser is at least partially made of a material diffusing to the electromagnetic radiation conveyed by the light guide, and has a curved shape.

The present disclosure relates to a laser irradiating apparatus including a laser resonator configured to generate a laser beam and output the laser beam forwards, a first passage part located in front of the laser resonator and configured to allow the laser beam generated from the laser resonator to pass through, and a second passage part located as being spaced from the first passage part and configured to allow the laser beam passing through the first passage part to pass through.

The present invention is directed to systems and methods for thermal therapy, especially to detection-guided, -controlled, and temperature-modulated interstitial thermal therapy. Thermal therapy may be used to treat the tissues of a patient. In the case of interstitial thermal therapy, energy is applied to generate heating of the tissue to affect treatment, such as, for example, thermally inducing tissue damage (e.g. thermally-induced tissue necrosis), which may be useful in treating tumors and/or other diseased tissues. Since targets for thermal therapy are internal to the patient, the use of detection guidance may be useful in locating and monitoring treatment of a target tissue.

A device includes an optical delivery fiber having a core having a first inside diameter joined to a capillary having an outer surface and a capillary tube having an inner surface. The capillary tube has a second inside diameter in the region of the joining to the optical delivery fiber. The second inside diameter is less than the first inside diameter of the delivery fiber.

Various methods, systems, and devices for treating tissue ablation are disclosed. Some embodiments disclosed herein pertain to methods of treating tumors, systems used for irradiating tissue and tumors with electromagnetic radiation, components and devices of that system, and kits for providing systems used for irradiating tissue and tumors with electromagnetic radiation. In some embodiments, the system provides sub-ablative infrared radiation that is absorbed by nanoparticles. In some embodiments, the nanoparticles absorb the radiation converting it into heat energy. In some embodiments, though the infrared radiation itself may be sub-ablative, the heat energy generated by the nanoparticles is sufficient to cause thermal coagulation, hyperthermia, and/or tissue ablation.

A device and a method for fractional skin treatment. The device employs two diffractive optical elements. One of the diffractive optical elements provides two coaxial laser beams and another diffractive optical element splits the two coaxial laser beams into a plurality of beamlets. A lens arranged to receive the plurality of the laser beams and to focus them in a skin treatment plane. The lens forms an image where each of the beamlets is imaged as a spot with a high intensity central area and a lower intensity area surrounding the central area.