Systems and method relate to administering phototherapy. A device includes a hollow structure having at least a first open end. The hollow structure includes a rotatable member, one or more coherent light generators, and, for each coherent light generator, one or more lenses or mirrors optically connected to the coherent light generator and configured to alter at least one aspect of a beam of coherent light. The device further includes a processing circuit including a processor and a memory storing instructions. The instructions, when executed by the processor, cause the processor to accept an input from an operator and generate one or more beams of coherent light according to a plurality of settings configured to produce a therapeutic effect at a targeted treatment site. Additionally, the rotatable member is configured to be rotated to direct the one or more beams of coherent light to the targeted treatment site.

The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

A catheter system (100) for treating a treatment site (106) within or adjacent to a vessel wall (108) or heart valve includes a first light source (124), a plurality of light guides (122A), a multiplexer (128) and a multiplexer alignment system (142). The first light source (124) generates light energy. The plurality of light guides (122A) are each configured to alternatingly receive light energy from the first light source (124). Each light guide (122A) has a guide proximal end (122P). The multiplexer (128) receives the light energy from the first light source (124). The multiplexer (128) alternatingly directs the light energy from the first light source (124) to each of the plurality of light guides (122A). The multiplexer alignment system (142) is operatively coupled to the multiplexer (128). The multiplexer alignment system (142) includes a second light source (270) that generates a probe source beam (270A) that scans the guide proximal end (122P) of each of the plurality of light guides (122A).

A catheter system (100) for treating a treatment site (106) within or adjacent to a vessel wall (208A) or a heart valve within a body (107) of a patient (109) includes an energy source (124), a balloon (104), an energy guide (122A), and a tissue identification system (142). The energy source (124) generates energy. The balloon (104) is positionable substantially adjacent to the treatment site (106). The balloon (104) includes a balloon wall (130) that defines a balloon interior (146). The balloon (104) can be configured to retain a balloon fluid (132) within the balloon interior (146). The energy guide (122A) is configured to receive energy from the energy source (124) and guide the energy into the balloon interior (146) so that plasma bubbles (134) are formed in the balloon fluid (132) within the balloon interior (146). The tissue identification system (142) can be configured to acoustically analyze tissue within the treatment site (106).

Laterally emitting optical waveguides and method introduce micromodifications into an optical waveguide and provide optical waveguides. The waveguides and methods comprise an optical wave-guiding core, a region in the optical waveguide, wherein the micro-modifications are arranged in the region of the optical waveguide, wherein the arrangement of the micro-modifications is ordered.

Systems and methods for creating multi-spot laser light beams, multiplexing an illumination light and the multi-spot laser light beams, and delivering the multiplexed light to a surgical handpiece via a multi-core optical fiber cable.

Devices, systems, and methods to measure a baseline temperature of a tissue prior to a laser ablation procedure are disclosed. The devices can be a thermometer including an optical fiber probe and a catheter. The catheter includes nanodiamonds embedded into a wall of the catheter. The nanodiamonds are excited by light from the optical fiber probe to emit a temperature dependent fluorescent light that is received by the optical fiber probe and transmitted to a temperature sensor. The temperature sensor can process the fluorescent light to calculate a temperature. The thermometer can be positioned adjacent to or within a target tissue structure prior to a laser ablation procedure to measure the baseline temperature. The baseline temperature can be input into a magnetic resonance imaging system to calculate a thermal damage estimate.

A probe of a target identification system can be extended via a first lumen of a viewing instrument, such as for illuminating an area beyond a distal end of the viewing instrument via an optical path of the viewing instrument. An optical response to the illumination of the area can be received via an optical path of the probe and can be split from other optical signals of the optical path. The optical response information can be used to identify characteristics of a target and to adjust parameters of a working instrument such as a working instrument contemporaneously using the probe.

A light treatment system includes: a probe configured to be inserted into a bladder, the probe including an optical fiber, and a diffuser that is provided at a distal end of the optical fiber, the diffuser being configured to emit the light from a surface of the cylindrical shape in a diffused manner; a balloon catheter into which the probe is inserted, the balloon catheter being configured to be inserted into the bladder, the balloon catheter including a distal end portion that is to be spherically dilated in the bladder; and a liquid that includes light scattering particles and fills inside of the distal end portion when the distal end portion has been dilated, the liquid having an equivalent scattering coefficient μ′.sub.s equal to or larger than 5/R, where R is a maximum radius of the distal end portion that has been dilated.

Laser ablation devices and related systems and methods may have laser outputs with multiple wavelengths. Laser ablation devices may include a laser energy source that can emit two or more laser outputs with different wavelengths. Some laser ablation devices include a processor to control the laser energy source to cause the laser energy source to emit a target wavelength blend with the laser outputs.