The present disclosure relates to a basket for a catheter designed to be deployed in complex vasculature to optimally treat vascular and arterial disease conditions such as blood clots, blood emboli, and deep vein thrombosis. The basket may comprise a shaft with a plurality of cuts along a portion of its length to form a plurality of tines that provide support for a plurality of porous tubes to form the limbs of the basket. The limbs of the basket expand radially away from the longitudinal axis of the basket when the longitudinal length of the basket is reduced. The limbs may also be connected to a drug delivery system, and in this manner, baskets of the present disclosure allow for the use of both mechanical and pharmaceutical means of thrombolysis.

The present disclosure relates to a system and method for coordinated laser delivery and imaging during an interventional procedure. A method may include activating an imaging source to provide a pulsed imaging signal and activating a laser source to provide a pulsed laser signal while the imaging source remains activated. The method may include coordinating the pulsed laser signal and the pulsed imaging signal to output each pulse of the pulsed laser signal and each pulse of the pulsed imaging signal in non-overlapping time windows. A system may include a controller in communication with the laser source and the imaging source for coordinating the output of the laser signal and the imaging signal.

A catheter system for treating a treatment site within or adjacent to a blood vessel within a body of a patient, the treatment site having a proximal region and a distal region, includes an energy source, a guide shaft, and an energy guide. The energy source generates energy. The guide shaft is positionable adjacent to the treatment site. The energy guide receives energy from the energy source. The energy guide is movably coupled to the guide shaft. The energy guide includes a guide distal end that is configured to be positioned adjacent to the treatment site. The guide distal end of the energy guide is selectively movable relative to the guide shaft and adjacent to and between the proximal region and the distal region of the treatment site while the energy guide receives energy from the energy source.

A catheter system for treating a treatment site within or adjacent to a vessel wall within a body of a patient includes an energy source, a balloon, and an energy guide. The energy source generates energy. The balloon includes a balloon wall that defines a balloon interior. The balloon is configured to retain a balloon fluid within the balloon interior. The balloon is selectively inflatable with the balloon fluid to expand to an inflated state, wherein when the balloon is in the inflated state the balloon wall is configured to be positioned substantially adjacent to the treatment site. The balloon further includes a balloon central axis that extends through a geometric center of the balloon when the balloon is in the inflated state. The energy guide selectively receives energy from the energy source and guides the energy from the energy source into the balloon interior. The energy guide including a guide distal end that is positioned on the balloon central axis when the balloon is in the inflated state.

A platform device for material excision or removal from vascular structures for either handheld or stereotactic table or robotics platform use may comprise a work element or elements configured to selectively open and close at least one articulable beak or scoopula configured to penetrate and remove intra-vascular materials or obstructions or follow a central lumen of another device or over a wire in a longitudinal direction. Flush and vacuum tissue transport mechanisms may be incorporated as well as single or multiple arrays of image guidance elements, directional elements, ablation elements and other interventional assistance elements. A single tube or an inner sheath and an outer sheath which may be co-axially disposed relative to a work element may be configured to actuate a beak or beaks or scoopulas and provisions for simultaneous or differential beak or scoopula closing under their differential rotation may be incorporated.

A light processing apparatus includes a first non-linear crystal disk for transmitting a first beam of photons having a first frequency to a second beam of photons having the first frequency and a second frequency oscillating in polarization directions orthogonal to each other, the second frequency being a half of the first frequency. Further included is a waveplate for transmitting the second beam of photons to a third beam of photons by rotating polarization directions of the second beam of photons such that the photons of the first frequency and of the second frequency oscillate in the same polarization directions. A second non-linear crystal disk is configured to transmit the third beam of photons to a fourth beam of photons of the first frequency, the second frequency and a third frequency, the third frequency being approximate a third of the first frequency.

Acoustic pressure shock waves are applied to a drug delivery structure implanted in tissue of a human or animal body and including one or more pouches that contain at least one drug in fluid form that is releasable from the drug delivery structure when targeted by the acoustic pressure shock waves.

Embodiments of the present invention include a laser catheter that includes a catheter body, a light guide, and a distal tip that extends beyond the exit aperture of the light guide. In some embodiments, an imaging device is disposed on the distal tip such that the imaging device is distal relative to the exit aperture of the light guide. In some embodiments, the imaging device can be gated to record images during and or slightly beyond periods when the laser catheter is not activated.

An extracorporeal pressure shock wave device includes a hinge providing a pivotable axis about which a shock wave applicator rotates to provide for adjusting the depth within a targeted body that a shock wave focal volume is produced from the applicator.

Systems, devices, and methods for delivering laser energy to a target in an endoscopic procedure are disclosed. An exemplary method comprises providing a first laser pulse train and a different second laser pulse train emitting from a distal end of an endoscope and incident on a target. The first laser pulse train has a first laser energy level, and the second laser pulse train has a second laser energy level higher than the first laser energy level. In an example, the first laser pulse train is used to form cracks on a surface of a calculi structure, and the second laser pulse train causes fragmentation of the calculi structure after the cracks are formed.