This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In a representative embodiment, a support frame configured to be implanted in a heart valve comprises a main body formed by formed by a plurality of inner members forming an inner clover and a plurality of outer members forming an outer clover. The support frame can include gaps located between inner members of the plurality of inner members and outer members of the plurality of outer members. The inner clover can be radially inside the outer clover, and the outer clover can have larger dimensions than the inner clover. The support frames herein can be radially expandable and collapsible.

An embodiment includes a process for treating an abdominal aortic aneurysm (AAA) endoleak with a shape memory polymer (SMP) foam device. First, a bifurcated stent graft is placed within the aneurysm while a micro guidewire is positioned within the aneurysm for future catheter access. Second, after placing the iliac graft extension, a catheter is introduced over wire to deliver embolic foams. Third, embolic foams expand and conform to the aneurysm wall. Fourth, embolic foams create a stable thrombus to prevent endoleak formation by isolating peripheral vessels from the aneurysm volume.

The present invention relates to a vascular prosthesis for a blood vessel of a patient, comprising: a hollow cylindrical main body having a prosthetic material, a longitudinal axis (L), and a stent frame, wherein the main body includes proximal and distal openings at proximal and distal ends, and wherein the vascular prosthesis having a first terminal stent ring attached to the prosthetic material at at least one end, and wherein the vascular prosthesis has at least one thread element attached thereto, wherein the at least one thread element reduces the diameter of the respective distal or proximal opening by tensile loading.

An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

Implantable medical devices for connecting tissue layers or occluding body conduits and tissue structures include apposition portions, a central region, and a covering material. The methods of using the devices include endoscopic deployment, and the devices may include self-expanding frameworks that facilitate a secure connection between the tissue structures. In some embodiments, one or more tethers are used to longitudinally contract the device in situ.

A multi-lumen stent-graft including a graft portion and a stent frame. The stent-graft includes multiple through-channels formed of the graft portion. The graft portion can comprise a PTFE material and the through-channels can be formed of fused portions of the graft portion. The stent-graft can be used in a prostheses that connects multiple vessel branches such as for the repair of aortic aneurysms or other vessels of the body.

A device for occluding a vasculature of a patient including a micrograft having an absorbent polymeric structure with a lumen of transporting blood. The micrograft has a series of peaks and valleys formed by crimping. The occluding device is sufficiently small and flexible to be tracked on a guidewire and/or pushed through a microcatheter to a site within the vasculature of the patient. Delivery systems for delivering the micrografts are also disclosed.

A system, for deployment in a blood vessel includes an anchor device having a stent and a suture loop that joins distal end portions of the stent. A first filling structure and a second filling structure are at least partially insertable through the suture loop to an area within the stent when the stent is in an expanded state. The anchor device has a size such that at least a portion of the first filling structure and at least a portion of the second filling structure protrude through openings in the anchor device to form a seal against a wall of the blood vessel when the first filling structure and the second filling structure have been at least partially inserted through the suture loop and have been filled. A method allows for repairing one or more blood vessels using the system.

A stent-graft system (100) includes a mainbody stent-graft (1), an outer branch (2), and at least one inner branch (3, 4). The mainbody stent-graft (1) is a tubular structure with covering membrane (102) on a surface thereof, forming a radially recessed concave portion (103) thereon. The outer branch (2) extends outside the mainbody stent-graft (1), with one end attached to a side wall of the concave portion (103). The inner branch (3, 4) is attached to the inside wall of the mainbody stent-graft (1), with an outer opening (31, 41) on the side wall of the concave portion (103), wherein the outer opening (31, 41) is distal to the inner opening (21).

Systems and methods for treating diseased bodily lumens involving branched lumen deployment sites include a main graft or stent-graft deployable in a main artery and a vent device or stent-graft deployable in a branch artery to maintain blood flow through the main artery and from the main artery to the branch artery. Systems and methods for treating diseased bodily lumens involving branched lumen deployment sites may also include a main graft or stent-graft deployable in the main artery, a chimney graft or stent-graft deployable in both branch artery and the main artery to the branch artery and a gutter-sealing device associated with the chimney graft to prevent flow of blood among the chimney graft, the main graft and a wall of the main artery.