Devices and methods for novel retinal irradiance distribution modification (IDM) to improve, stabilize or restore vision are described herein. Also encompassed herein are devices and methods to reduce vision loss from diseases, injuries and disorders that involve damaged and/or dysfunctional and/or sensorily deprived retinal cells. Conditions that may be treated using devices and methods described herein include macular degeneration, diabetic retinopathy and glaucoma. Therapy provided by retinal IDM devices and methods described herein may also be used in combination with other therapies including, but not limited to, pharmacological, retinal laser, gene and stem cell therapies.

Apparatuses, systems and methods for providing improved intraocular lenses (IOLs), include features for reducing side effects, such as halos, glare and best focus shifts, in multifocal refractive lenses and extended depth of focus lenses. Exemplary ophthalmic lenses can include a continuous, power progressive aspheric surface based on two or more merged optical zones, the aspheric surface being defined by a single aspheric equation. Continuous power progressive intraocular lenses can mitigate optical side effects that typically result from abrupt optical steps. Aspheric power progressive and aspheric extended depth of focus lenses can be combined with diffractive lens profiles to further enhance visual performance while minimizing dysphotopsia effects. The combination can provide an increased depth of focus that is greater than an individual depth of focus of either the refractive profile or the diffractive profile.

A method of treating a lens of a patient's eye includes generating a light beam, deflecting the light beam using a scanner to form a treatment pattern of the light beam, delivering the treatment pattern to the lens of a patient's eye to create a plurality of cuts in the lens in the form of the treatment pattern to break the lens up into a plurality of pieces, and removing the lens pieces from the patient's eye. The lens pieces can then be mechanically removed. The light beam can be used to create larger segmenting cuts into the lens, as well as smaller softening cuts that soften the lens for easier removal.

A system and method of treating target tissue in a patient's eye, which includes generating a light beam, deflecting the light beam using a scanner to form first and second treatment patterns, delivering the first treatment pattern to the target tissue to form an incision that provides access to an eye chamber of the patient's eye, and delivering the second treatment pattern to the target tissue to form a relaxation incision along or near limbus tissue or along corneal tissue anterior to the limbus tissue of the patient's eye to reduce astigmatism thereof.

Lenses and methods are provided for improving peripheral and/or central vision for patients who suffer from certain retinal conditions that reduce central vision or patients who have undergone cataract surgery. The lens is configured to improve vision by having an optic configured to focus light incident along a direction parallel to an optical axis at the fovea in order to produce a functional foveal image. The optic is configured to focus light incident on the patient's eye at an oblique angle with respect to the optical axis at a peripheral retinal location disposed at a distance from the fovea, the peripheral retinal location having an eccentricity between 30 degrees and 30 degrees. The image quality at the peripheral retinal location is improved by reducing at least one optical aberration at the peripheral retinal location. The method for improving vision utilizes ocular measurements to iteratively adjust the shape factor of the lens to reduce peripheral refractive errors.

An intraocular device that includes a base member is provided. The device can be an accommodation intraocular lens device with the base member and a power changing lens. The base member comprises an annular haptic that surrounds a central cavity having an open end. The power changing lens is configured to fit within the central cavity. The haptic comprises one or more projections, e.g., tabs that hold another device in position. In the case of the accommodating intraocular lens device, the other device is the power changing lens. The base member and the power changing lens are maintained separate until assembly in the eye of the patient. During assembly, the base member is advanced into the capsular bag of a patient through a capsulorhexis and oriented such that the open end of the central cavity faces the cornea. Subsequently, the power changing lens is advanced into the central cavity through the capsulorhexis. The one or more tabs are placed anterior of the power changing lens to secure the power changing lens within the cavity.

An ophthalmic lens includes an optic comprising an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface has a surface profile including a base curvature, a refractive region having the base curvature, and a diffractive region comprising a diffractive profile including a plurality of diffractive steps. At least a portion of the diffractive profile constitutes a combination of a base diffractive profile defining multiple foci for the ophthalmic lens and an achromatizing structure that reduces longitudinal chromatic aberrations.

Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs), include features for providing improved extended depth of focus lenses. Exemplary ophthalmic lenses can include an optic including a diffractive profile including at least one set of echelettes, each echelette of the set having a different width in r-squared space than any other echelette of the set and the at least one set of echelettes repeating at least once upon the optic.

An accommodating intraocular lens with variable optical power, comprising at least two optical elements, at least one of which is movable relative to the other in a direction perpendicular to the optical axis, wherein the optical elements form a lens with different optical power at different relative positions of the optical elements. At least two of the optical elements of the lens comprise at least one additional optical correction surface, which correction surfaces are adapted for simultaneous variable correction of one or more optical aberrations of the natural eye in which the degree of correction depends on the relative position of the optical elements.

Certain embodiments are directed to lenses, devices and/or methods. For example, a lens for an eye having an optical axis and an aberration profile along its optical axis, the aberration profile having a focal distance and including higher order aberrations having at least one of a primary spherical aberration component C(4,0) and a secondary spherical aberration component C(6,0). The aberration profile may provide, for a model eye with no aberrations and an on-axis length equal to the focal distance: (i) a peak, first retinal image quality (RIQ) within a through focus range that remains at or above a second RIQ over the through focus range that includes said focal distance, where the first RIQ is at least 0.35, the second RIQ is at least 0.1 and the through focus range is at least 1.8 Diopters; (ii) a RIQ of 0.3 with a through focus slope that improves in a direction of eye growth; and (iii) a RIQ of 0.3 with a through focus slope that degrades in a direction of eye growth. The RIQ may be Visual Strehl Ratio or similar measured along the optical axis for at least one pupil diameter in the range 3 mm to 6 mm, over a spatial frequency range of 0 to 30 cycles/degree inclusive and at a wavelength selected from within the range 540 nm to 590 nm inclusive.