The present application is generally directed to implantable systems, devices and related methods pertaining to spinal surgery. In particular, the present application discloses a frame and spacer system for inserting into a disc space. The frame and spacer system is of low profile. The frame can receive different fixation devices, including threaded and non-threaded fixation devices.

A system includes a first prosthesis. The first prosthesis may include a body extending along a length from a first side to a second and including a third side disposed between the first side and the second side. The body may include a pair of spaced apart rails between which a channel is defined. A stem and a first fixation element may extend upwardly from the third side. A method may include coupling the first prosthesis to bone.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

A medical implant includes a body and a porous structure attached to the body. A boss integral with the body extends outwardly from a surface of the body. The porous structure has a surface that cooperates with the boss of the body to prevent pullout of the body from the porous structure. In fabricating the medical implant, the body and the porous structure are formed separately and subsequently secured together.

Bone implants, including methods of use and assembly. The bone implants, which are optionally composite implants, generally include a distal anchoring region and a growth region that is proximal to the distal anchoring region. The distal anchoring region can have one or more distal surface features that adapt the distal anchoring region for anchoring into iliac bone. The growth region can have one or more growth features that adapt the growth region to facilitate at least one of bony on-growth, in-growth, or through-growth. The implants may be positioned along a posterior sacral alar-iliac (“SAI”) trajectory. The implants may be coupled to one or more bone stabilizing constructs, such as rod elements thereof.

A system for replacing a hip joint can include a first acetabular cup formed of a first material and having a first inner diameter and a first thickness. A second acetabular cup can be formed of a second material and having a second inner diameter and a second thickness. A first femoral hip prosthesis can include a first femoral head that is alternately accommodated by either of the first or second acetabular cups. A bearing can be adapted to be interposed between the first femoral head and one of the first or second acetabular cups. The first and second inner diameters can be the same. The first thickness can be less than the second thickness. The first material can be distinct from the second material.

In an artificial joint that includes a head assembly attached by taper fit to a proximal portion of a surgically implanted stem, it may become necessary to surgically remove the head assembly. A puller can simultaneously apply a force distally to a non-peripheral portion of a proximal side of the head assembly and proximally to several locations spaced apart around a circumference of the distal side of the head assembly. In some examples, the proximal side of the head assembly includes a plug disposed at the non-peripheral portion. The puller can force the plug into contact with the proximal end of the stem, then apply the distal force through the plug to the stem. In other examples lacking a plug, the non-peripheral portion of the head can deform or break in response to the applied distal force, so that the distal force can apply to the stem.

A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.

Bone implants, including methods of use and assembly. The bone implants, which are optionally composite implants, generally include a distal anchoring region and a growth region that is proximal to the distal anchoring region. The distal anchoring region can have one or more distal surface features that adapt the distal anchoring region for anchoring into iliac bone. The growth region can have one or more growth features that adapt the growth region to facilitate at least one of bony on-growth, in-growth, or through-growth. The implants may be positioned along a posterior sacral alar-iliac (“SAI”) trajectory. The implants may be coupled to one or more bone stabilizing constructs, such as rod elements thereof.

An interbody spacer for a spine includes a housing having a plurality of clearance holes configured to engage bone of the spine. A contact plate including a plurality of apertures is positioned a distance away from the housing configured to engage bone of the spine. A plurality of rivets adjoin the housing and the contact plate. A plurality of springs are included with each spring configured to encircle a respective rivet and translate the distance between the housing and contact plate from a minimum distance to a maximum distance.