Bone implants, including methods of use and assembly. The bone implants, which are optionally composite implants, generally include a distal anchoring region and a growth region that is proximal to the distal anchoring region. The distal anchoring region can have one or more distal surface features that adapt the distal anchoring region for anchoring into iliac bone. The growth region can have one or more growth features that adapt the growth region to facilitate at least one of bony on-growth, in-growth, or through-growth. The implants may be positioned along a posterior sacral alar-iliac (“SAT”) trajectory. The implants may be coupled to one or more bone stabilizing constructs, such as rod elements thereof.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

A tibial support of an artificial knee joint, comprising a main tibial support body (100) and a tibial support platform (200), wherein the main tibial support body (100) is wing-shaped, a central axis thereof being vertical to the tibial support platform (200). A plurality of hollow screw holes is provided at the upper part of the main body (100). The tibial support platform (200) is located above the main tibial support body (100). The surface of the tibial support platform (200) is an organic polymer material layer matching a tibial liner. The hollow screw holes in the tibial support are sealed by the polymer material layer. Because a tibial support of an artificial knee joint adopts a high-biocompatibility organic polymer material, physical machining is allowed in an operation, and meanwhile, the surface corrosion of the tibial support is reduced. Hollow screw holes are sealed by means of a polymer material layer, thereby inhibiting joint liquid from entering the holes, and reducing the transportation of particles. Recesses (201) are provided at positions, corresponding to the screw holes, on the polymer surface, thereby aiding in drilling holes and mounting screws in an operation.

A customized artificial temporomandibular joint unit according to an embodiment of the present disclosure includes a first plate provided along a lower line of a lower jawbone forming a temporomandibular joint and having an insertion groove that is outwardly open, a second plate provided at a temporal bone forming the temporomandibular joint together with the lower jawbone, and a main prothesis detachably combined to the first plate without a separate fastening device by being forcibly fit into the insertion groove while approaching the first plate, and arranged in a customized manner at a facing surface location facing the second plate.

The invention relates to an augmentation device comprising an annular cone surrounding a channel which extends axially along a longitudinal axis of the augmentation device from a proximal cone end to a distal cone end, wherein an outer diameter of the cone decreases from the proximal cone end in the direction of the distal cone end.

A method of placing an implant for intervertebral fusion between adjacent vertebral bodies in a patient includes inserting the implant in a space between the adjacent vertebral bodies such that both a first intervertebral spacer body and a second intervertebral spacer body contact each of the adjacent vertebral bodies. The first intervertebral spacer body is spaced apart from the second intervertebral spacer body. An expandable container portion of the implant disposed between the first intervertebral spacer body and the second intervertebral spacer body is filled with fill material such that the expandable container expands to contact each of the adjacent vertebral bodies.

The present disclosure discloses the hip prosthesis containing zirconium-niobium alloy on oxidation layer and a preparation method thereof, the hip prosthesis comprises a femoral stem, a femoral head, liners and a shell; the shell and femoral stem are prepared by using zirconium-niobium alloy powder as a raw material, and performing Sinter-HIP, cryogenic cooling and surface oxidation; the prepared shell and femoral stem are provided with partitioned trabeculae and formed by 3D printing. The problem of traditional manufacturing methods cannot process complex structures and failure of connection between sleeve and femoral handle is solved by 3D printing technology. Meanwhile, the preparation method can improve the bonding strength between trabecular bone and solid, and improve the service life of prosthesis.

A flexible bone implant includes a proximal stem having a proximal end, a distal end, and a proximal conduit extending from the proximal end to the distal end of the proximal stem, whereby the proximal conduit is open at both the proximal and distal ends of the proximal stem. The implant includes a distal stem having a proximal end, a distal end, and a distal conduit extending from the proximal end to the distal end of the distal stem, whereby the distal conduit is open at both the proximal and distal ends of the distal stem. The implant includes a flexible hinge interconnecting the distal end of the proximal stem with the proximal end of the distal stem for allowing the proximal and distal stems to flex relative to one another. A proximal stem protective tube is disposed within the proximal conduit of the proximal stem and has a length that matches the length of the proximal conduit, and a distal stem protective tube is disposed within the distal conduit of the distal stem and has a length that matches the length of the distal conduit. The proximal stem, the distal stem and the flexible hinge comprise a unitary structure made of a polymer material.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

The present invention discloses a metal-ceramic composite joint prosthesis and applications and a manufacturing method thereof. The joint prosthesis comprises a metal body and a ceramic body, wherein the metal body is integrally formed and comprises a porous structure layer, a boundary layer and a root-like layer, the boundary layer is located between the porous structure layer and the root-like layer, the root-like layer comprises a plurality of root-like filament clusters connected to the boundary layer but not in contact with one another, each root-like filament cluster comprises a main root perpendicularly connected to the boundary layer and a plurality of fibrous roots connected to the lateral side of the main root, the fibrous roots extend obliquely towards the side away from the boundary layer, and the ceramic body covers the root-like filament clusters and is formed on the boundary layer. The joint prosthesis achieves the compositing of metal and ceramic, thereby achieving both a wear-resistant ceramic body required for a joint friction surface and a porous metal structure with a good bone ingrowth effect required for an osseointegration surface. The root-like filament clusters of the root-like layer are rooted in the ceramic body, to form a tight and stable connection between the ceramic body and the metal body, and the root-like clusters being not in contact with one another prevents the ceramic body from locally breaking or cracking.