Embodiments of this application relate to the use of porous coating implants to repair soft tissue injuries. Implant frames are coated with a porous coating, such as a titanium porous coating, for example, on both the bone-facing and the soft tissue-facing sides of the implant. The implant may then be sandwiched between the bone and soft tissue so that the bone grows into one side, and the soft tissue grows into the other side.

A containment body for making a spacer device or a device to be implanted in a human body that is suitable for treating a bone seat or a joint of the human body includes a base portion and side walls that extend from the base portion and that delimit between them at least one cavity, wherein the containment body has a plurality of pores and/or at least one opening, configured to place the at least one internal cavity in communication with the outside of the containment body.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

An implant system for implantation at a joint, the implant system including an implant device, the implant device comprising a body portion having first and second ends, and a first elongate member, extending from the first or second end of the body portion, the first elongate member being insertable in a bone tunnel in a subject's tibia.

A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.

The present application is generally directed to implantable systems, devices and related methods pertaining to spinal surgery. In particular, the present application discloses a frame and spacer system for inserting into a disc space. The frame and spacer system is of low profile. The frame can receive different fixation devices, including threaded and non-threaded fixation devices.

An interbody spacer for a spine includes a housing having a plurality of clearance holes configured to engage bone of the spine. A contact plate including a plurality of apertures is positioned a distance away from the housing configured to engage bone of the spine. A plurality of rivets adjoin the housing and the contact plate. A plurality of springs are included with each spring configured to encircle a respective rivet and translate the distance between the housing and contact plate from a minimum distance to a maximum distance.

An implant assembly is shown and described. The implant has at least one or a plurality of elastic, resilient or flexible arms that each have a detent adapted to retain at least one screw in a locked position in the implant. At least one of the arms has a portion that extends into a screw aperture such that an arm axis is generally parallel to the axis of the screw after the screw is received in the implant. In another embodiment, means or a system for locking the multi-component implant members together is shown.

This invention corresponds to a prosthesis for total or hip resurfacing replacement, which comprises a prosthetic femoral head made of highly cross-linked polyethylene, with a diameter ranging from 38 mm to 64 mm, to articulate with a cup or acetabular component made of metal. When the invention applies to total hip replacement, the polyethylene head includes a metal core, which contains inside the female counterpart (14) to mate with the male counterpart (13) of a Morse taper, located at the upper end of the femoral component. The use of this type of head for total hip replacement, articulated with an ultra-polished acetabular cup, reduces the risk of dislocation, transmits less angular and torque forces to the Morse taper than large metal heads, and avoids the problems related to the metal-metal bearing or with the use of large metal heads with thin polyethylene. When the invention relates to hip resurfacing replacement, the highly cross-linked polyethylene femoral head has a lower polyethylene extension or stem with or without internal metal reinforcement (151) or a metal stem integrated into a metal-back (152). Using these types of heads for hip resurfacing replacement heads eliminates the problems associated with metal-on-metal resurfacing replacements.

The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal. The invention is further directed toward a repaired cartilage defect.