Provided herein are rapid and effective local infection therapy methods, systems, and devices that significantly reduce the mortality, morbidity, and the cost of care in rare musculoskeletal infections. Continuous delivery of antibiotic therapy locally, at the infection site, reduces edema and provides antibiotic irrigation, significantly improving outcomes while reducing the need for systemic antibiotics.

The invention discloses a glenoid prosthesis baseplate, having a surface (1) for an artificial socket insert, an opposite fitting surface (2), and holes (2f) passing through the surfaces (1, 2), and feet (3) on the surface (1) for the artificial socket insert for fixing the artificial socket insert. The baseplate has at least two mounting tabs (4) connected to the edge (P) of the baseplate, and holes (4a) passing through each mounting tab (4), and the prosthesis baseplate is provided with at least two through holes (2f) passing through both the surface (1) for the artificial socket insert and the fitting surface (2), and each hole (2f) being in alignment with the axis of a through hole (4a) of the mounting tab (4).

The process for producing an orthopedic implant having an integrated silicon nitride surface layer includes steps for positioning the orthopedic implant inside a vacuum chamber, mixing nitrogen gas and vaporized silicon atoms in the vacuum chamber, emitting a relatively high energy beam into the mixture of nitrogen gas and vaporized silicon atoms in the vacuum chamber to cause a gas-phase reaction between the nitrogen gas and the vaporized silicon atoms to form reacted precipitate silicon nitride molecules, and driving the precipitate silicon nitride molecules with the same beam into an outer surface of the orthopedic implant at a relatively high energy such that the precipitate silicon nitride molecules implant therein and form at least a part of the molecular structure of the outer surface of the orthopedic implant, thereby forming the integrated silicon nitride surface layer.

An intervertebral bone fusion implantable device configured with flexible structural elements on its top and bottom surfaces for controlled dampening of the compressive force exerted on the device by two vertebrae and for the maximization of the contact surface between the device and the uneven endplates of the vertebrae.

An expandable interbody device for placement between adjacent vertebrae having an upper structure, a lower structure and a screw mechanism, wherein actuation of the screw mechanism moves the upper and lower structures between a collapsed configuration and an expanded configuration. A deployment tool couples to the expandable interbody device for positioning the device between adjacent vertebrae, actuating the screw mechanism and delivering a material to a chamber of the expandable interbody device.

A spinal implant includes a base and a coating film disposed on the base and including a calcium phosphate-based material and an antimicrobial agent. A surface of the base includes a first region in which the coating film is disposed and a second region exposed from the coating film.

Orthopedic implants and related surgical methods for using same. The implants have suture bore geometries that facilitate performance of the surgical methods, thereby providing for improved optimal biomechanical force application in various anatomies. The implants include suture bores that have an angled/diagonal, or skewed, orientation within the anatomical planes (lateral/sagittal and frontal/coronal). The suture bores have the skewed orientation so that the adjacent soft tissues (i.e., tendons or ligaments) can be advanced via the suture therethrough in superior-inferior and inferior-superior directions. Openings, or holes, at the ends of the suture bores are configured to approximate the adjacent associated soft tissue to the implant.

In one or more embodiments orthopaedic implants may be provided. The implants may include an expansile structure which may allow for increased contact between an endosteal or periosteal surface for initial fixation and further allow for bone in-growth and/or on-growth. In some embodiments the expansile structure may be made of, for example a NiTiNol structure, which may further be programmed for expansion at body temperatures. In some embodiments the interstices of the expansile structure may further be filled with a shape memory polymer and/or other elastic material which may also be programmed for expansion at body temperatures.

A humeral implant is disclosed. The implant has a humeral surface component and a stem. The humeral surface component has an articular surface and is configured for fixation to an articular portion of a proximal humerus. The stem is configured for post-surgery axial movement within the humerus. The stem is connected to the humeral surface component opposite of the articular surface. A method of implanting a humeral implant is also disclosed.

This invention features methods and devices for ameliorating implant-induced inflammation and for reducing the risk of fibrosis. The methods and devices include a substrate coated with P-15 peptide positioned at the site of implantation.