An orthopedic prosthesis mold, comprising a first housing including a first cavity therein shaped to form a portion of an orthopedic prosthesis; a second housing coupled to the first housing, the second housing including a second cavity therein shaped to form a portion of an orthopedic prosthesis, wherein the first and second housings are constructed from a material having a first hardness; a first shell element configured to receive at least a portion of the first housing therein; a second shell element configured to receive at least a portion of the first housing therein, wherein the first and second shell elements are constructed from a material having a second hardness greater than the first hardness; and a connection element releasably engageable to the first and second shell elements to prevent separation of the first shell element from the second shell element.

Misaligned bones on opposite sides of a joint are aligned using a first rigid extension securable to one of the misaligned bones using a particular surgical approach, and a second rigid extension having a contacting surface positionable in contact with the other the two misaligned bones from the same surgical approach. The first and second rigid extensions are moved with respect to each other using a lever, whereby a pulling force is exerted on one of the bones, and a pushing force on the other, thereby aligning the first and second misaligned bones.

Provided are methods and devices for assessing biological particles for use in cell immunotherapy. By utilizing a microfluidic chip device together with optical force measurement and cell imaging, the methods enable comprehensive assessment and characterization of biological particles with regard to morphology, motility, binding affinities, and susceptibility to external forces, including but not limited to, chemical, biochemical, biological, physical and temperature influences. The methods enable the selection and production of biological particles, such as engineered T-cells, for use in immunotherapy and biomanufacturing.

The invention primarily relates to fastening and stabilizing tissues, implants, and/or bondable materials, such as the fastening of a tissue and/or implant to a bondable material, the fastening of an implant to tissue, and/or the fastening of an implant to another implant. This may involve using an energy source to bond and/or mechanically to stabilize a tissue, an implant, a bondable material, and/or other biocompatible material. The invention may also relate to the use of an energy source to remove and/or install an implant and/or bondable material or to facilitate solidification and/or polymerization of bondable material.

An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

Provided is an implantable composite which includes a plurality of resorbable ceramic particles with or without a biodegradable polymer. The resorbable ceramic particles can be granules including carbonated hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 70:30. Some resorbable ceramic particles are granules, which include carbonated hydroxyapatite and β tricalcium phosphate in a ratio of 5:95 to 70:30. The resorbable ceramic particles have a particle size from about 0.4 to about 3.5 mm. The implantable composite is configured to fit at or near a bone defect as an autograft extender to promote bone growth. Methods of using the implantable composite are also provided.

Spinal interbody cages are provided that include a bulk interbody cage, a top face, a bottom face, pillars, and slots. The pillars are for contacting vertebral bodies. The slots are to be occupied by bone of the vertebral bodies and/or by bone of a bone graft. The spinal interbody cage has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1.

The invention relates to an augmentation device comprising an annular cone surrounding a channel which extends axially along a longitudinal axis of the augmentation device from a proximal cone end to a distal cone end, wherein an outer diameter of the cone decreases from the proximal cone end in the direction of the distal cone end.

Described herein are devices, systems and methods for treating disease and/or infection by the release of silver from an implant over an extended period of time. In particular, the devices described herein may be used to treat infections such as osteomyelitis by the controlled release of silver ions from multiple sites of an extended-use implant. This implant typically includes a plurality of arms that both anchor and help distribute the released ions within the tissue. Power may be applied to release the silver ions into the tissue.

An implant may include a body having a first blade having a first retracted position in the body and a first extended position where the first blade extends outwardly from the body, a second extendable blade, and a blade actuating member configured to translate through the body in directions parallel to the lateral axis. When the blade actuating member is moved in a first direction along the lateral axis, the first blade moves towards the first extended position; and in the first extended position, the first blade extends from the superior surface at a first non-zero angle with respect to the superior-inferior axis; and the second blade moves towards a second extended position in which the second blade extends from the inferior surface at a second non-zero angle with respect to the superior-inferior axis.