The present disclosure relates to a three-dimensionally (3D) printed tissue engineering scaffold for tissue regeneration and a method for manufacturing the 3D printed tissue engineering scaffold. The 3D printed tissue engineering scaffold may be fabricated at least in part from a composite material having an insoluble component and soluble component. The three-dimensional tissue scaffolds of the disclosure may be fabricated via a rapid prototyping machine. In some instances, the three-dimensional shape of the fabricated tissue engineering scaffold may correspond to a three-dimensional shape of a tissue defect of a patient.

A medical implant has a hierarchical surface roughness and includes an implant body, which includes a combination of meso-scale surface features, micro-scale surface features, and nano-scale surface features.

One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

The present invention is directed generally to (1) an articulating junction, and articulation method thereof, wherein articulation is facilitated by a plurality of magnetic particles; (2) an articulating junction, and articulation method thereof, wherein the stability and fluidity of the junction is based, at least in part, on the magnetic field(s) of the plurality of magnetic particles; and (3) reducing the resistance to articulation and/or increasing the structural integrity and support, of the articulating junction, via electro-magnetism. Further, the present invention is directed generally to the synergistic combination of magnetic particles and preferred bio-implant-materials and additive-manufacturing methods along with Baker correlation codes. Further, the present invention is directed to an artificial joint for implantation into a living body and methods for constructing such an artificial joint.

Invasive surgical devices such as joint implants and surgical tools are provided with a coating of visible or near visible light stimulated TiO.sub.2 based photocatalysts. The coatings may comprise one or more layers of different TiO.sub.2 crystal phases and may incorporate metal nodules. The devices reduce the incidence of infection via antimicrobial and bactericidal surface properties. Related devices and methods for illumination, air purification, and packaging are disclosed that comprise a complete system for use of the devices in surgical procedures.

A prosthesis may have an articulating component formed via casting and a 3D printed bone anchoring component with a joint-facing side and a bone-facing side. The bone-facing side may have a bone engagement surface with a porous structure with pores selected to facilitate in-growth of the bone into the pores. The bone facing side may further have a surface layer of Titanium Dioxide nanotubes. The joint-facing side may be secured to the articulating component by melting Titanium nanoparticles at a temperature below the melting temperatures of the major constituents of the articulating component and/or the bone anchoring component, such as Cobalt, Chromium, and/or Titanium, so as to avoid significantly modifying the crystalline structures of the articulating component and/or the bone anchoring component. The melting temperature of the Titanium nanoparticles may be about 500 C.

Methods of manufacturing produce metal implants having nano-modified surfaces that contain antimicrobial properties. The methods may include immersing the implant in an acid, rinsing the acid-treated implant in an aqueous cleaner, and thereafter heating the rinsed implant. The nano-modified implants described herein may contain an increased surface roughness; surface features with increased width or height; and/or decreased surface energy. The implants that result from these methods contain a nano-modified surface that is resistant to microbial cell adhesion and ultimately reduce biomaterials-related infections at the implant site.

A biological tissue rootage face (30) capable of closely bonding to a biological tissue (H, S) is composed of a biocompatible material and has numerous fingertip-shaped microvilli (41). The microvilli (41) have tip diameters in the order of nanometers. An implant (1) has the biological tissue rootage face (30) on a surface (11, 24) configured to root into a biological tissue (H, S). In a method for forming the biological tissue rootage face (30), a surface of a biocompatible material is subjected to laser nonthermal processing carried out by emitting a laser beam in air, to form numerous fingertip-shaped microvilli (41). The laser beam is a laser beam of an ultrashort pulse laser.

A knee arthroplasty system may have a femoral joint prosthesis with a femoral bone engagement surface with an anterior portion, a posterior portion, and a distal portion that connects the anterior portion to the posterior portion. A first femoral anchoring member may protrude from the distal portion, and may be connected to the anterior portion with a primary femoral web. A tibial resection guide may have a base member and a guide member with a slot that guides a cutting blade to resect the tibial plateau. The guide member may slide along an arcuate path relative to the base member.

Disclosed is a medical device having a first implant portion having a proximal end, a second implant portion connected to the first implant portion, the second implant portion having a distal end, and a driver assembly removably connected to the distal end, the driver assembly comprising a drill connected to the distal end at a connection.