Computer implemented methods of producing a mesh implant having a compartment to enclose a bone material therein are provided. These methods include generating a 3D digital model of the mesh implant having the compartment, the 3D digital model including a virtual volume of the compartment and a virtual depth, thickness and volume of the mesh implant; generating a 3D digital model of a covering configured for closing the compartment of the mesh implant, the 3D digital model including a virtual volume of the covering for closing the compartment of the mesh implant; and instructing a 3D printer coupled to a computer to generate the mesh implant based on the 3D digital models. A computer system for making a mesh implant and a delivery system including the mesh implant are also provided.

The present invention pertains to an implant for treatment of a bone lesion site, the implant including a polymer porous film and a layer containing a biocompatible material, wherein the polymer porous film is a polymer porous membrane of a three-layer structure having a porous surface layer A, a porous surface layer B, and a macrovoid layer interposed between the surface layer A and the surface layer B; the average pore diameter of the pores in surface layer A is smaller than the average pore diameter of the pores in surface layer B; the macrovoid layer has a partition joined to the surface layers A and B and a plurality of macrovoids enclosed by the partition and the surface layers A and B; and the pores in the surface layers A and B communicate with the macrovoids.

An replacement for a human includes a body having a superior surface, an inferior surface, a distal surface, and a proximal surface. The proximal surface is configured to engage the talus and the calcaneus of an adult human, and the distal surface configured to engage at least the first and fourth metatarsals of the adult human. The distal surface has a largest distal height and a largest distal width that is greater than the largest distal height, and the proximal surface has a largest proximal height and a largest proximal width that is greater than the largest proximal height.

The present disclosure relates to a system for augmentation of a tibial component. The system includes an augmentation component having a first porous structure, a second porous structure, a top portion having a top surface, and a bottom portion having a bottom surface arranged opposite the augmentation component from the top surface. The system also includes a tibial component and an instrument, with the tibial component being configured to couple to the augmentation component. The instrument includes an engagement portion having a geometry complimentary to that of the augmentation component. Further, a method of augmenting a tibial component is disclosed with the steps of collecting imaging data from a patient, identifying a void in the distal tibia, obtaining an augmentation component that corresponds to the void, coupling the augmentation component to the tibial component and implanting the tibial component into the tibia so the augmentation component occupies the tibial void.

The improved endoprosthetic device surface treatment encourages soft tissue attachment thereto. A porous mesh surface treatment creates on an outer surface of the endoprosthetic device a three-dimensional surface structure similar to cancellous bone. Suture attachment features are provided at various locations around the treated surface structure to initially affix a vascularized soft tissue to the treated surface. As the patient heals the soft tissue grows and infiltrates the porous mesh surface to achieve an attachment strength substantially equal to the surrounding tissue.

There is disclosed a bone fixation device that can include a cage having an optional mesh portion. The bone fixation device can be configured to couple a leg portion to a foot portion of a user's body. In at least one embodiment, the device includes at least one cage having a plurality of struts forming cells. There can be an optional mesh portion having a pre-set porosity that can be either constant or variable in density. In at least one embodiment there can be a cage portion which is substantially spherical shaped. Alternatively, the device can be substantially egg shaped. In at least one embodiment there can be a central post hole for receiving a post. In another embodiment at least one plate or shaft can connect to the cage.

The present invention relates to a vertebral system comprising a vertebral implant (2) and a plurality of inserts, said implant being designed to be implanted in a vertebral segment composed of at least two vertebrae and including a body (20) the walls whereof delimit a cavity (23) leading to the outside of the body (20) through at least one opening in at least one of said walls, at least one passage (21) passing through the implant (2) from the periphery to an upper or lower surface to receive a bone-anchoring device (1) capable of anchoring the implant (2) in at least one of said vertebrae, the system being characterized in that it includes at least two inserts selected from among the following inserts: at least one graft insert (3, 3A, 3B, 4, 5A, 5B, 6A, 6B, 6C, 6D, 202, 250) capable of being colonized by bone tissue and/or receiving at least one bone tissue graft and/or at least one substitute; and/or at least one bone-anchoring insert (210) comprising said passage (21) capable of receiving said bone-anchoring device (1).

The present disclosure provides a system of gender specific pharmaceuticals. The system includes a first package of a pharmaceutical for use by a male and a second package of a pharmaceutical for use by a female. The first package includes a pharmaceutical for use by a male and a first label coupled to the first package, wherein at least one of the first package and first label includes a male specifier and a recommended male dosage. The second package includes a pharmaceutical for use by a female and a second label coupled to the second package, wherein at least one of the second package and second label includes a female specifier and a recommended female dosage.

For inserting a cage in the intervertebral disk space between two vertebrae, an instrument set includes a guide wire with a plurality of dilators that can be pushed over the guide wire and one over another, with a working sleeve and with a cage, in which the working sleeve is designed in its distal area such that it makes possible the fixation of its distal area in the direction of its extension with angular mobility or variable angular orientability of its proximal end.

This invention relates to and orthopaedic implant having an expansion means adapted to increase the external surface area of the implant, the expansion means positioned to correspond to voids or depressions in the anatomy of a patient. Also described are method for the design and manufacture of such implants.