An interbody endeap comprises at least one member configured for connection with an interbody implant. The at least one member has a thickness that permits bone growth therethrough and a uniform surface configuration that resists and/or prevents egress of bone graft from a cavity of the interbody implant. Systems and methods are disclosed.

Computer implemented methods of producing a mesh implant having a compartment to enclose a bone material therein are provided. These methods include generating a 3D digital model of the mesh implant having the compartment, the 3D digital model including a virtual volume of the compartment and a virtual depth, thickness and volume of the mesh implant; generating a 3D digital model of a covering configured for closing the compartment of the mesh implant, the 3D digital model including a virtual volume of the covering for closing the compartment of the mesh implant; and instructing a 3D printer coupled to a computer to generate the mesh implant based on the 3D digital models. A computer system for making a mesh implant and a delivery system including the mesh implant are also provided.

A device for strengthening new joints in animals after joint replacement surgery includes a flexible bone anchor that connects to the new implant material on one end and to cortical bone on the other end.

An expandable implant for inserting within a skeletal space is provided, and a method for using the implant to expand the skeletal space. The implant is preferably designed to be inserted into an intervertebral space to replace at least part of an intervertebral disc between adjacent vertebral bodies. The expandable implant contains at least one first expansion compartment and at least one second expansion compartments, which compartments can be inflatable balloons that are inflated by a catheter. Inflating the first expansion compartment expands the implant in a first direction and inflating the second expansion compartment expands the implant in a second direction.

Disc degeneration and chronic back pain are caused by a transport hindrance of oxygen, nutrients and pH buffer from capillaries in endplates into mid-layer of the intervertebral disc. A fluid absorbing conduit is inserted into the intervertebral disc, drawing and delivering the oxygen, nutrients and pH buffer in fluid of body circulation from capillaries at endplates into the mid-layer of the disc. The disc undergoes thousands of relaxation and compression cycles each day from daily activity of the patient. During relaxation phase, the fluid of body circulation containing oxygen, nutrients, and pH buffer is infused into the fluid absorbing conduit. During compression phase, the oxygen, nutrients, and pH buffer in the fluid absorbing conduit is dispersed into the mid-layer of the disc. The pH buffer, bicarbonate, neutralizes the lactic acid to relieve the discogenic pain. Oxygen inhibits hypoxic inflammation and production of lactic acid to further reduce the discogenic pain. Nutrients nourish the disc cells to rebuild or regenerate the disc matrix.

Therapeutic agents can be added into the fluid absorbing conduit or injected into the disc implanted with the fluid absorbing conduit to expedite pain relief and disc regeneration. The therapeutic agents can be pH buffering agent, antibiotic, anti-inflammatory drug, anesthetic, antacid, nutrient, sulfate, anti-depressant, calcium channel blocker, growth factor, cells or other.

Implantable drug-eluting device comprising a microporous structure having regularly arranged pores in at least two different uniform sizes, and manufacturing method. The pores are configured for receiving a drug and are being connected by interconnections. Interconnections originating from pores of a first size have a first elution area and interconnections originating from pores of a second size have a second elution area. The interconnections convey the drug to a surface of the device for elution to surrounding tissue. The ratio between the first and the second elution areas is predefined and selectable. The differently sized elution areas provide for different outflow rates. This allows for simple but reliable dispensing of drugs at positively controlled and well determined rates. Particularly, this enables a single implantable device to dispense drugs over preselectable durations of time, like short-term or long-term.

A device for containing bone graft material includes a mesh outer sleeve extending longitudinally from a proximal end to a distal end and sized and shaped to correspond to a profile of an outer surface of a target bone. The outer sleeve includes a longitudinal slot extending along a length thereof. The device also includes a mesh inner sleeve connected to an interior surface of the outer sleeve via at least one strut so that a bone graft collecting space is defined therebetween. The inner sleeve is sized and shaped to correspond to a profile of a medullary canal of the target bone. In addition, the device includes an interstitial mesh extending radially away from an exterior surface of the inner sleeve toward an interior surface of the outer sleeve to hold graft material in the bone graft collecting space.

In various embodiments, an implant for interfacing with a bone structure includes a web structure including a space truss. The space truss includes two or more planar truss units having a plurality of struts joined at nodes and the web structure is configured to interface with human bone tissue. In some embodiments, a method is provided that includes accessing an intersomatic space and inserting an implant into the intersomatic space. The implant includes a web structure including a space truss. The space truss includes two or more planar truss units having a plurality of struts joined at nodes and the web structure is configured to interface with human bone tissue.

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are optimized for the expected stress applied at the bone structure site.

An intervertebral implant for positioning within an intervertebral space between adjacent first and second vertebral bodies. The intervertebral implant includes an implant body extending along a longitudinal axis of the intervertebral implant that is adapted to align with a vertical axis of the spine. The implant body includes a top plate and a bottom plate disposed longitudinally opposite and spaced apart from the top plate along the longitudinal axis. Further, the implant body includes at least one cross-arm obliquely extending between the top plate and the bottom plate. Furthermore, the implant body includes a lattice structure disposed at least between the at least one cross-arm and the top plate and between the at least one cross-arm and the bottom plate.