This disclosure describes manufacturing of a device configured to guide bone and tissue regeneration for a bone defect. A method may include receiving a three-dimensional digital model or scan representing an anatomical feature to be repaired, generating a simulated membrane using the three-dimensional model, the simulated membrane being configured to cover the anatomical feature to be repaired, generating a digital two-dimensional flattened version of the simulated membrane, and generating code or instructions configured to cause a three-dimensional printer or milling device to produce a trimming guide that includes an opening corresponding to the flattened version of the simulated membrane and that further includes a cut-out configured to hold a premanufactured membrane. The trimming guide may be operative as a guide for marking or cutting the premanufactured membrane through the opening while the premanufactured membrane is held in the cut-out.

A method of manufacturing a surgical implant includes simultaneously forming a first component and a second component of the surgical implant. Formation of the first and second components includes depositing a first quantity of material to a building platform and fusing the first quantity of material to form a first layer of the first and second components. The method of manufacturing also includes depositing a second quantity of material over the first layer of the first and second components and fusing the second quantity of material to form a second layer of the first and second components. The surgical implant is fully assembled upon the completion of the formation of the first and second components.

Disclosed is a patient-specific mandibular implant inserted into a mandibular defect region and a method of manufacturing the same, and more particularly, to a patient-specific mandibular implant inserted into a mandibular defect region, which can be easily and rapidly manufactured using personalized three-dimensional (3D) printing technology for a defect region, can provide an effect of preparing a later step for restoring a tooth in advance, and can be easily manufactured tooth restoration data based on the Korean standard database (DB), and a method of manufacturing the same.

A method for producing bone grafts using 3-D printing is employed using a 3-D image of a graft location to produce a 3-D model of the graft. This is printed using a 3-D printer and a printing medium that produces a porous, biocompatible, biodegradable material that is conducive to osteoinduction. For example, the printing medium may be PCL, PLLA, PGLA, or another approved biocompatible polymer. In addition such a method may be useful for cosmetic surgeries, reconstructive surgeries, and various techniques required by such procedures. Once the graft is placed, natural bone gradually replaces the graft.

A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.

A knee prosthesis comprises a unicondylar knee prosthesis having a unicondylar insert platform and a tibial base attached to a bottom side of the unicondylar insert platform. The unicondylar insert platform has a uniform stiffness gradient (e.g., a density or porosity gradient), whereas the tibial base has a non-uniform stiffness gradient (e.g., a density or porosity gradient) when the tibial base is viewed from a cross-sectional coronal plan. For example, the tibial base may have an area of greatest stiffness or density centrally located relative to an inboard and outboard side of the tibial base. Alternatively, the area of greatest stiffness or density may be located toward the outboard side. Additionally, the tibial base may include density wells having increased density relative to the surrounding area of the tibial base.

A method for producing a tailor-made implant intended to be implanted at an implantation site of a damaged bone part, the method comprising a step in which a 3D representation of a standard implant is superposed on a 3D representation of a damaged bone part by positioning said standard implant on an implantation site of the damaged bone part, in order, if necessary, to modify the dimensions and/or to adjust the shape of said standard implant, and also, if necessary, to modify the outer surface of said standard implant, which may be either the impression or substantially the impression of the outer surface of said bone part in the state prior to superpositioning of said implant, when the geometry of the damaged bone part is intended to be retained, or a functional outer surface, when said tailor-made implant is intended to be used at the interface of two bone parts cooperating with each other.

The present invention relates to a medical implant for cartilage and/or bone repair at an articulating surface of a joint. The implant comprises a contoured implant body and at least one extending post. The implant body has an articulating surface configured to face the articulating part of the joint and a bone contact surface configured to face the bone structure of a joint, where the said articulating and bone contact surfaces face mutually opposite directions and said bone contact surface is provided with the extending post. A cartilage contact surface connects the articulating and the bone contact surfaces and is configured to contact the cartilage surrounding the implant body in a joint. The articulating surface has a layer that consists of titanium nitride (TiN) as the wear-resistant material. The cartilage contact surface has a coating that substantially consists of a material having chondrointegration properties.

An implant is produced by fabricating first and second layers. The first layer of repeated and truncated building units is fused together to define pores. The second layer of repeated and truncated building units are fused together to define pores and fused onto the first layer of truncated building units. The first and the second layers form at least part of a porous portion of the implant. The formed porous portion is attached onto a base portion of an implant. The truncated building units of each of the first and the second layers are in the form of spatially overlapping three-dimensional shapes.

The present invention includes a method for generating a three-dimensional model of a bone and generating a cut plan for excavating a portion of the bone according to the cut plan to allow the insertion of a custom implant. In a particular arrangement, the method also includes excavating the bone with an autonomous extremity excavator utilizing the cut plan generated by a processor. In a further arrangement, the method includes generating a digital model of a custom implant and generating, using the digital model, a physical model sharing the same dimensions as the digital module using manufacturing device.