The intervertebral fusion device (200) comprises a superior component (220), an inferior component (240) and a core component (260). The superior and inferior components (220, 240) are received in an intervertebral space between first and second vertebrae whereby the superior component top side abuts against the first vertebra, the inferior component bottom side abuts against the second vertebra, and the superior component bottom side and the inferior component top side oppose each other. A height of the intervertebral fusion device is determined upon insertion of the core component (260) between the superior and inferior components (220, 240). Each of the superior component top side and the inferior component bottom side is one of: oblong having a major axis; and square, being bounded by four edges. During insertion of the core component (260) a first core profile of the core component cooperates with a superior component profile at the superior component bottom side and a second core profile of the core component cooperates with an inferior component profile at the inferior component top side whereby the core component moves in a direction oblique to the major axis where the superior component top side or the inferior component bottom side is oblong or to an edge of the superior component top side or the inferior component bottom side where the superior component top side or the inferior component bottom side is square.

The invention primarily relates to fastening and stabilizing tissues, implants, and/or bondable materials, such as the fastening of a tissue and/or implant to a bondable material, the fastening of an implant to tissue, and/or the fastening of an implant to another implant. This may involve using an energy source to bond and/or mechanically to stabilize a tissue, an implant, a bondable material, and/or other biocompatible material. The invention may also relate to the use of an energy source to remove and/or install an implant and/or bondable material or to facilitate solidification and/or polymerization of bondable material.

A spinal implant system includes at least one interbody implant having a first member including a tissue engaging surface and at least one mating element. A second member includes a tissue engaging surface and at least one mating element. An intermediate member includes at least one mating element. An intra-operative surgical tool is connectable with at least one of the members to engage adjacent mating elements and fix the intermediate member with at least one of the first member and the second member. Implants, surgical instruments and methods are disclosed.

The present invention discloses a metal-ceramic composite joint prosthesis and applications and a manufacturing method thereof. The joint prosthesis comprises a metal body and a ceramic body, wherein the metal body is integrally formed and comprises a porous structure layer, a boundary layer and a root-like layer, the boundary layer is located between the porous structure layer and the root-like layer, the root-like layer comprises a plurality of root-like filament clusters connected to the boundary layer but not in contact with one another, each root-like filament cluster comprises a main root perpendicularly connected to the boundary layer and a plurality of fibrous roots connected to the lateral side of the main root, the fibrous roots extend obliquely towards the side away from the boundary layer, and the ceramic body covers the root-like filament clusters and is formed on the boundary layer. The joint prosthesis achieves the compositing of metal and ceramic, thereby achieving both a wear-resistant ceramic body required for a joint friction surface and a porous metal structure with a good bone ingrowth effect required for an osseointegration surface. The root-like filament clusters of the root-like layer are rooted in the ceramic body, to form a tight and stable connection between the ceramic body and the metal body, and the root-like clusters being not in contact with one another prevents the ceramic body from locally breaking or cracking.

The present invention relates to an intervertebral fusion device (10) comprising a superior component (12), an inferior component (14) and a core component (16). The superior component (12) and the inferior component (14) are receivable in an intervertebral space between first and second vertebrae with the core component (16) insertable between the superior and inferior components to determine a separation between the superior and inferior components. A bone graft conveying aperture is defined in at least one of a superior component top surface (18) of the superior component and an inferior component bottom surface (20) of the inferior component. The core component defines a bone graft material holding space which is enclosed except at at least one of a core component top surface and core component bottom surface of the core component and a bone graft material delivery opening. The bone graft material delivery opening extends from outside the core component side to the bone graft material holding space. The bone graft material delivery opening is closed by a closure component.

Embodiments may include an attachable fastener, which may include a bondable material that may be secured to the end of an end effector. Vibration may be tuned to occur at a distal end of the fastener. Accordingly, the fastener may be used to generate heat at a distal point of contact. If the contact surface contains bondable material, that material may be softened. If the fastener includes bondable material at the point of contact, that material may also be softened by heat produced by vibration at the contact area. A hard implant or another polymeric material may function as the anvil.

Dural repair devices that are configured to effectively and reliably repair the damage of a dural tear due to incidental durotomies are provided, along with methods of use. The devices and methods enhance the ability of a surgeon to repair a patent's dura mater, or dura, during surgery of the central nervous system. The dural repair device has a multi-layer structure configured to exert a pressure or tamponade effect to compress a patient's dura to its state prior to the spinal surgery. Thus, the dural repair devices and methods of use may reduce the patient's risk morbidity, further surgery, spinal headaches, or other injuries and discomforts.

This invention corresponds to a prosthesis for total or hip resurfacing replacement, which comprises a prosthetic femoral head made of highly cross-linked polyethylene, with a diameter ranging from 38 mm to 64 mm, to articulate with a cup or acetabular component made of metal. When the invention applies to total hip replacement, the polyethylene head includes a metal core, which contains inside the female counterpart (14) to mate with the male counterpart (13) of a Morse taper, located at the upper end of the femoral component. The use of this type of head for total hip replacement, articulated with an ultra-polished acetabular cup, reduces the risk of dislocation, transmits less angular and torque forces to the Morse taper than large metal heads, and avoids the problems related to the metal-metal bearing or with the use of large metal heads with thin polyethylene. When the invention relates to hip resurfacing replacement, the highly cross-linked polyethylene femoral head has a lower polyethylene extension or stem with or without internal metal reinforcement (151) or a metal stem integrated into a metal-back (152). Using these types of heads for hip resurfacing replacement heads eliminates the problems associated with metal-on-metal resurfacing replacements.

The invention relates generally to generation of biomimetic scaffolds for bone tissue engineering and, more particularly, to multi-level lamellar structures having rotated or alternated plywood designs to mimic natural bone tissue. The invention also includes methods of preparing and applying the scaffolds to treat bone tissue defects. The biomimetic scaffold includes a lamellar structure having multiple lamellae and each lamella has a plurality of layers stacked parallel to one another. The lamellae and/or the plurality of layers is rotated at varying angles based on the design parameters from specific tissue structural imaging data of natural bone tissue, to achieve an overall trend in orientation to mimic the rotated lamellar plywood structure of the naturally occurring bone tissue.

An implant can be implantable into a human body and can include a metallic substrate and a ceramic layer. The metallic substrate can be formed by additive manufacturing. The metallic substrate can be engageable with a bone. The metallic substrate can include an inner surface, an outer surface, and a plurality of retention features. The inner surface can define a plurality of pores configured to promote bone ingrowth into the metallic substrate. The plurality of retention features can include a proximal portion connected to the outer surface and the proximal portion can define a proximal width. The ceramic layer can be a bearing surface that can be spray coated to the metallic substrate and formed around the retention features to interlock the ceramic layer with the metallic substrate.