The invention is a needle valve comprising at least one hollow needle and a seat. The hollow needle is comprised of a smooth surfaced hollow shaft and a port adapted to allow fluid communication between the interior and the exterior of said needle located in the side of the shaft at the distal end close to the tip of said needle. The seat comprises at least one bore adapted to accommodate one of the at least one needles through it. The needle and the bore can move one relatively to the other and the bore is provided in, or is fitted with, resilient material such that the outer diameter of the needle is greater than the inner diameter of at least part of the bore. As a result the passage of the shaft of the needle in the bore creates a closely-matched shaft and sheath, which blocks the passage of fluid through the port.

There is provided a connector, for introducing or extracting a material to or from at least one receptacle, comprising a housing extending between a distal end and a proximal end, the housing comprising, at least at one end, a pierceable seal; a hollow needle mounted, at least partially, within the housing between the distal end and the proximal end of the housing, a first end of the hollow needle being connected or connectable to a first corresponding receptacle, and a second end of the hollow needle facing the pierceable seal at an end of the housing; and an actuating mechanism acting on the housing or the hollow needle to enable the hollow needle to pierce the pierceable seal thereby forming a communication through the pierceable seal, such that material is able to transfer through the connector.

A reconstitution device includes: a piercing member having a first end and a second end, the first end of the piercing member configured to engage an administration port; a delivery member having a first end and a second end, the first end of the delivery member configured to engage a delivery site; a collar configured to engage a vial; and a cap extending from the collar and holding the piercing member and the delivery member such that the second end of the piercing member and the second end of the delivery member are disposed within the cylindrical collar.

An adapter assembly for establishing bidirectional fluid connection between a cartridge and a vial includes a housing having an open first end adapted to engage the cartridge and a second open end adapted to engage the vial. The adapter includes a needle assembly having a first tip and a second tip, with the needle assembly disposed within the housing and at least partially supported by a needle holder. The needle assembly is movable relative to the housing from an initial position in which the first and second tip are isolated from the cartridge and vial, to an end of use position, in which first tip is engaged with the vial and the second tip is engaged with the cartridge, establishing fluid communication therebetween. The needle assembly is maintained in the initial position by a locking structure which is released by rotationally advancing the needle holder relative to the housing.

The invention relates to a fluid transfer system (1) for transferring medical substances or drugs. It further relates to components and parts of such a transfer system (1), in particular its connecting components (2, 6) and the parts equipped with such connecting components (2, 6), such as syringes (4), containers (vials) (8) or application systems. According to the invention, a screw connection of the connecting components (2, 6) to each other is provided with regard to a particularly good dosability of the applied holding forces. In addition, a needle cap (2) made of comparatively soft, elastic material is provided as a seal and sealing closure for the hollow needles (40, 42) provided as actual transfer channels in the connection component (2).

A liquid concentrate generation system may comprise a manifold having an inlet receptacle including a first piercing member, an outlet receptacle including a second piercing member, and a flow channel connecting the inlet receptacle and outlet receptacle. The system may further comprise a cartridge having an inlet port and an outlet port sealed by a respective first and second cover. The inlet and outlet port may be respectively configured to displace within the inlet receptacle and outlet receptacle from an unspiked position to a spiked position. First and second piercing members may be in communication with the flow channel and spaced apart respectively from the first and second cover in the unspiked position. The first and second piercing members may be isolated from the flow channel and may respectively puncture the first and second cover in the spiked position.

In drug mixing devices of disclosed embodiments, a main flow path extending from one end configured to allow liquid inside the first container to enter the main flow path therethrough to another end configured to allow liquid inside the second container to enter the main flow path therethrough, and a branch flow path branching from the main flow path are formed. The drug mixing device includes a body including a first connection part configured to be coupled with the first container and a second connection part configured to be coupled with the second container, and a backflow prevention part disposed in a partial flow path of the main flow path extending to the one end with reference to the connection point of the main flow path and the branch flow path, the backflow prevention part being configured to prevent liquid from flowing from the connection point to the one end.

Assembly with connectable and disconnectable elements comprises a flexible bag containing liquid solution with a first valve connector, at least one vial with active substance and provided with a hermetic closing cap, a coupling and piercing device couplable to the cap of the vial and an adapter between the first connector and the coupling and piercing device. The adapter has a hollow external body with a first end fixable by screwing to the first connector, an axially bored, coaxial internal stem, the screwing causes the opening of the first connector and a second end including a second valve connector fixable to the coupling and piercing device and is screwable in the external body so that internal stem causes the opening of the second valve connector.

Transfer devices with vial adapter and/or an infusion set for reducing overdosing/underdosing of an infusion bag are provided. The transfer device provides user- controlled fluid transferring between an infusion liquid container and a drug-containing container. In one aspect, the transfer device provides user-controlled venting that can be used during liquid transfer between the infusion liquid container and a drug-containing container.