An apparatus and method for aseptically filling a container utilizing an adaptor formed of severable and heat-sealable material connected to a tube and container. The adaptor includes a membrane which is unsealed to allow filling by a known filling machine. Once the adaptor tube and container is formed as a unit, it is sterilized. The adaptor is then severed and sealed, creating a usable aseptic liquid product.

A container system includes at least one flexible wall defining a compartment containing a dissolvable solid or concentrate, a support adjacent a first end of the at least one flexible wall, and a nozzle assembly coupled to a second end of the at least one flexible wall. The second end of the wall is distal from the first end. The nozzle assembly comprises a hollow body defining a longitudinal axis. The hollow body further defines a plurality of orifices through a wall thereof. Each orifice is able to form a fluid connection between an interior volume within the hollow body and the compartment. Each orifice is configured to deliver liquid from the interior volume to the compartment in a direction having an angle of between 5° and 85° from a direction of the longitudinal axis. Related nozzles and methods are also disclosed.

The present disclosure relates to a sterile medical product for parenteral nutrition comprising a polymeric container having at least a first and a second chamber which are separated by a non-permanent peel seal, wherein the first chamber contains a composition of amino acids and optionally electrolytes, and wherein the second chamber contains a dextrose solution, and wherein the product is characterized by a high protein (nitrogen) content per volume. The reconstituted solution is configured to be administered peripherally or centrally for the treatment of patients suffering from malnutrition and/or having a need for increased uptake of amino acids.

A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.

A package for use with a beneficial agent delivery device. The package includes at least one filling chamber having a sealed penetrable access region, at least one compartment configured to hold a content, wherein the content includes at least one of a beneficial agent or a constituent of a beneficial agent, and at least one channel connecting the at least one filling chamber in fluid communication with the at least one compartment. At least a portion of the package is resealable to contain the content.

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

A package comprising a container for holding a first sub-stance, and a product insert for holding a second substance, at least partially inserted info said container, and where the first product and the second product can be allowed to merge by external manipulation of said package. Packaged products and methods are also provided.

A method for identification of the most abundant oligonucleotide species in a library of oligonucleotides comprising more than 10.sup.6 oligonucleotide species, wherein the oligonucleotides of the library of oligonucleotides are not inherently capable of exponential amplification by PCR and include a coding sequence, which is characteristic of one oligonucleotide specie of the library of oligonucleotides and only one fixed sequence, which is present in a plurality of oligonucleotide species of the library of oligonucleotides, said fixed sequence being located on a 5′ side of the coding sequence, and wherein the method comprises specifically amplifying the sequence of a hybridised oligonucleotide species using the steps of: incubating the library of oligonucleotides under conditions of hybridization such as to allow complementary coding sequences to hybridize and form hybridized oligonucleotide species; extending a 3′ end of one or more of the hybridised oligonucleotide species, having only one fixed sequence, to provide extended sequences having an extended region, such that the extended region generates a second fixed sequence thereby forming extended sequences having two fixed sequences; amplifying extended sequences comprising two fixed sequences using PCR to provide amplified sequences, and optionally identifying an identity of the amplified sequences thereby revealing an identity of the hybridised oligonucleotide species in the step of incubating. The library of oligonucleotides is selected from the group of a library of encoded molecules, a library of aptamers, a library of reporter sequences derived from a library of encoded molecules, and a library of aptamers.

A package comprising a container for holding a first substance, and a product insert for holding a second substance, at least partially inserted info said container, and where the first product and the second product can be allowed to merge by external manipulation of said package. Packaged products and methods are also provided.

The present invention relates, in some embodiments thereof, to systems, devices, connection ports, and methods allowing for an engagement of two or more pharmaceutical vessels, containers, or pharmaceutical administration devices in a decontaminated and/or sterile manner. In some embodiments of the invention, the systems, devices, connection ports, and methods of the invention include a dual decontamination action device having a wiping member and a removable sealing member, a system comprising a device having a wiping member and a removable sealing member and a connection port having a removable sealing member. A first removable sealing member attached to a housing of a device is provided, the housing further comprising a wiping member configured to move across the housing; and a connection port having a removable sealing member, both removable sealing members configured to displace from the engagement between the device and the connection port while a hermetically sealed connection is maintained between the device and the connection port. In some embodiments of the invention, the systems, devices, connection ports and methods include a wiping member that is configured to wipe off the surface(s) of the engaged device and connection port, thus providing a decontaminated/sterile fluid communication between the device and the connection port.