The present invention relates, in some embodiments thereof, to connectors having cavities and systems comprising same for allowing an engagement and fluid passageway between medical vessels. In some embodiments, the connectors allow repeatable fluid transfer between vessels. In some embodiments, the connectors configured to connect between a plurality of medical vessels.

The present invention relates, in some embodiments thereof, to connectors having cavities and systems comprising same for allowing an engagement and fluid passageway between medical vessels. In some embodiments, the connectors allow repeatable fluid transfer between vessels. In some embodiments, the connectors configured to connect between a plurality of medical vessels.

A sterile product bag includes a bladder, a stem, a filter, and a vial adaptor. The bladder has a perimeter seal and defining a sterile chamber. The stem extends through the perimeter seal and has an inlet end outside of the perimeter seal and an outlet end in fluid communication with the chamber. The filter is disposed in line with the stem and has a filter membrane with a nominal pore size in a range of approximately 0.1 m to approximately 0.5 m. The filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The vial adaptor includes a sterile hollow cannula, a sheath, and a peelable closure. The cannula is in fluid communication with the chamber of the bladder. The sheath is disposed outside of the bladder and connected to the hollow cannula. The sheath includes an interior cavity into which the hollow cannula extends. The peelable closure extends across an opening of the sheath to seal the interior cavity.

A flexible container incorporating flexible front and rear sheets with a perimeter seal in which at least one length or section of the perimeter seal can include a seal weld that has both a permanent seal section and a pressure absorbing seal section. The pressure absorbing seal section is configured to peel, fail, or split when the flexible container, filled with a solution or liquid, is dropped onto a hard surface to thereby absorb the impact of the drop. The flexible container can be provided with one or more dispensing and/or additive ports or without any port. The flexible container may include more than one compartments with a peelable seal separating two adjoining compartments of the flexible container.

A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.

A medical product includes a bladder, a filtration device, and a sterile product concentrate. The bladder has a perimeter seal and defining a sterile chamber. The filtration device includes a stem and a filter membrane disposed in line with the stem. The stem extends through the perimeter seal and has an inlet end accessible from outside of the perimeter seal and an outlet end in fluid communication with the sterile chamber. The filter membrane can have a nominal pore size in a range of approximately 0.1 m to approximately 0.5 m, wherein the filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The sterile product concentrate is disposed in the sterile chamber and adapted to be reconstituted by the introduction of a pharmaceutical fluid into the chamber through the filtration device.

A method of preparing a pharmaceutical product in a single multiple chamber flexible bag. A pharmaceutical product is introduced in a liquid state into a first chamber of the flexible bag through a first port. The pharmaceutical product is lyophilized within the first chamber of the flexible bag to provide a lyophilized pharmaceutical product. The flexible bag has a second chamber and the first chamber and the second chamber are separated by a breakable seal. The second chamber further includes a reconstituting solution for reconstituting the lyophilized pharmaceutical product in the first chamber. A user may apply pressure to the flexible bag to break the seal and mix the lyophilized pharmaceutical product and the reconstituting solution to order to administer the pharmaceutical product to a patient.

A method of preparing a pharmaceutical product in a single multiple chamber flexible bag. A pharmaceutical product is introduced in a liquid state into a first chamber of the flexible bag through a first port. The pharmaceutical product is lyophilized within the first chamber of the flexible bag to provide a lyophilized pharmaceutical product. The flexible bag has a second chamber and the first chamber and the second chamber are separated by a breakable seal. The second chamber further includes a reconstituting solution for reconstituting the lyophilized pharmaceutical product in the first chamber. A user may apply pressure to the flexible bag to break the seal and mix the lyophilized pharmaceutical product and the reconstituting solution to order to administer the pharmaceutical product to a patient.

The present invention relates, in some embodiments thereof, to systems, devices, and methods allowing for an engagement of two or more pharmaceutical vessels or pharmaceutical administration devices in a decontaminated manner. In some embodiments of the invention, the systems, devices and methods of the invention include a housing comprising a first compartment connectable to a first vessel's port; and a second compartment connectable to a second vessel's port, wherein the first and second compartments are engageable with each or integrally connected to each other, and wherein the first vessel is moveable within the housing from a first position wherein the vessel is connected to the first compartment, to a second position wherein the vessel is connected to the second compartment, wherein a substantially sterile aperture of the first vessel and/or second vessel is covered by a displaceable plate, and wherein prior to or at about the time of connection of the first vessel in the second position, the displaceable plate displaces from the aperture, allowing an substantially decontaminated engagement and fluid passageway between the first and second vessels.

A medical bag having at least two compartments, a peelable seal between the compartments, a permanent seal on the contour of the bag and at least one filling tube further comprising an opening with no seal on one of the compartments. The at least one tube for filling, comprises an opening with no seal on one of the compartments, and it comprises two labels on the compartment, a label being located on the rear side and the other label being located on the front face of the bag, the opening onto one of the compartments constituting a film excess on top of a label, the excess being sealed only on one of the sides, but not horizontally and being flexible enough to facilitate easy opening.