A liquid-transfer adapter operatively interposable between an injector and a vial is provided. The liquid-transfer has an injector engaging portion configured for fluidly coupling to an injector and a vial coupling. The vial coupling includes a spike that has a spike axis and a tip portion configured for piercing a septum of a vial. The tip portion includes a plurality of facets that meet each other at one or more edges and at least one of the one or more edges is sloped with respect to the spike axis. The spike defines a channel extending therethrough in fluid communication with the injector engaging portion. A channel opening is defined in at least one of the facets and disposed without interrupting the edges.

A cap assembly includes an access member configured for attachment to a reservoir. The access member includes a first port that enables needleless extraction of contents from the reservoir, and at least one second port that enables needled extraction of the contents from the reservoir. The cap assembly further includes a valve member positioned in or configured to be positioned in the access member to i) enable needleless extraction of the contents of the reservoir through the first port when the first port is attached to a needless extraction device, ii) enable needled extraction of the contents through the at least one second port, and iii) seal the contents of the reservoir at the first port and at the at least one second port prior to and subsequent to the needleless or needled extraction.

A drug container connector (1) is provided with a puncture needle (20) capable of puncturing a plug (186) that seals a mouth (183) of a container (180); and a cover (90) that covers an opening, on a tip side, of a flow channel (21) formed in the puncture needle (20). The puncture needle (20) is configured to penetrate the cover (90) and puncture the plug (186). The puncture needle (20) is provided on a connector main body (10). The cover (90) is held by a slider (50). The slider (90) is movable with respect to the connector main body (10) in a longitudinal direction of the puncture needle (20). The slider (50) is provided with claws (66, 76) capable of engaging with a flange (182) at the mouth of the container (180).

A membrane for use in connection with a closed system transfer device has a body with a proximal portion opposite a distal portion along a central axis and a skirt extending radially outward from the distal end such that a lip is formed at a transition between the proximal portion and the distal portion. The membrane further has at least one well recessed in a proximal direction from a distal end of the distal portion, thereby forming a channel within the distal portion having an open first end, a closed bottom end, and a pair of sidewalls extending between the first end and the second end. At least one slit extends through at least a portion of the body in a direction of a plane aligned along or parallel to the central axis.

A membrane for use in connection with a closed system transfer device has a body with a proximal portion opposite a distal portion along a central axis and a skirt extending radially outward from the distal end such that a lip is formed at a transition between the proximal portion and the distal portion. The membrane further has at least one well recessed in a proximal direction from a distal end of the distal portion, thereby forming a channel within the distal portion having an open first end, a closed bottom end, and a pair of sidewalls extending between the first end and the second end. At least one slit extends through at least a portion of the body in a direction of a plane aligned along or parallel to the central axis.